Featured
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Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy
- Constance d’Abrigeon
- , Mairéad G. McNamara
- & Julien Edeline
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Article
| Open AccessACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype
- Michelle Shen
- , Shiqin Liu
- & Tanya Stoyanova
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Review Article
| Open AccessThe role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control
- Jinhai Deng
- , Teng Pan
- & Tony Ng
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Review Article
| Open AccessMolecular response assessment using circulating tumor DNA (ctDNA) in advanced solid tumors
- Jeffrey C. Thompson
- , Dylan G. Scholes
- & Charu Aggarwal
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Article
| Open AccessTargeting oncogenic microRNAs from the miR-371~373 and miR-302/367 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption
- Shivani Bailey
- , Marta Ferraresso
- & Matthew J. Murray
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| Open AccessEvaluation of tumour infiltrating lymphocytes in luminal breast cancer using artificial intelligence
- Shorouk Makhlouf
- , Noorul Wahab
- & Emad Rakha
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| Open AccessDNA damage response inhibitors enhance tumour treating fields (TTFields) potency in glioma stem-like cells
- Aurelie Vanderlinden
- , Callum G. Jones
- & Spencer J. Collis
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Vitamin C intake and colorectal cancer survival according to KRAS and BRAF mutation: a prospective study in two US cohorts
- Shanshan Shi
- , Kai Wang
- & Mingyang Song
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| Open AccessDevelopment and validation of a multivariable model for prediction of malignant transformation and recurrence of oral epithelial dysplasia
- Hanya Mahmood
- , Adam Shephard
- & Syed Ali Khurram
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Review Article |
Liquid biopsy: creating opportunities in brain space
- Rakesh Trivedi
- & Krishna P. Bhat
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Mismatch Repair system protein deficiency as a resistance factor for locally advanced rectal adenocarcinoma patients receiving neoadjuvant chemo-radiotherapy
- Andrea Pretta
- , Pina Ziranu
- & Mario Scartozzi
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| Open AccessEvidence into practice: a national cohort study of NICE-recommended oncological drug therapy utilisation among women diagnosed with invasive breast cancer in England
- Melissa Ruth Gannon
- , David Dodwell
- & David Alan Cromwell
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| Open AccessLoss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation and alterations in DNA repair: implications for therapeutic strategies
- Chloe Gulliver
- , Sebastian Huss
- & Ralf Hoffmann
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| Open AccessDifferential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level
- N. M. Atallah
- , M. Alsaleem
- & E. Rakha
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Review Article |
Checkpoint inhibitors and anti-angiogenic agents: a winning combination
- Patrick Brest
- , Baharia Mograbi
- & Gerard Milano
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Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer
- Masayuki Shirasawa
- , Tatsuya Yoshida
- & Yuichiro Ohe
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Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
- Yanchao Zhang
- , Guomeng Zhao
- & Changying Guo
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| Open AccessA first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer
- Daphne Day
- , John J. Park
- & Archie N. Tse
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Article
| Open AccessCharacterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets
- Felix Bremmer
- , Pailin Pongratanakul
- & Daniel Nettersheim
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Article
| Open AccessIncreased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma
- Maureen Jacob
- , Sara Wiedemann
- & Meike Vogler
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| Open AccessA spectroscopic liquid biopsy for the earlier detection of multiple cancer types
- James M. Cameron
- , Alexandra Sala
- & Matthew J. Baker
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BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARγ/PDK1 dependent manner
- Qian Wang
- , Ning Liang
- & Gang Wang
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The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer
- Jie Mei
- , Yun Cai
- & Yan Zhang
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| Open AccessHistological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis
- Takanori Matsuura
- , Yoshihide Ueda
- & Tomonori Matsumoto
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| Open AccessInsights adjusting for non-adherence in randomized clinical trials: a reanalysis of an adjuvant trial of tamoxifen duration in early breast cancer
- Fabiola Giudici
- , Barbara Pistilli
- & Aurelie Bardet
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Review Article
| Open AccessFumarate hydratase (FH) and cancer: a paradigm of oncometabolism
- Lorea Valcarcel-Jimenez
- & Christian Frezza
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Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors—a randomised controlled trial (SURfit)
- Corina S. Rueegg
- , Simeon J. Zürcher
- & Susi Kriemler
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Article
| Open AccessLoss of NDUFS1 promotes gastric cancer progression by activating the mitochondrial ROS-HIF1α-FBLN5 signaling pathway
- Tao Chen
- , Dongbao Li
- & Jin Zhou
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PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies
- Vishnu Kumarasamy
- , Zhe Gao
- & Erik S. Knudsen
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Article
| Open AccessSynthetic viability induces resistance to immune checkpoint inhibitors in cancer cells
- Mingyue Liu
- , Qi Dong
- & Yunyan Gu
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| Open AccessAnti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis
- Maren Juliane Egidi
- , Sebastian Krug
- & Heidi Griesmann
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Article
| Open AccessEx vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
- Ioannis Ntafoulis
- , Anne Kleijn
- & Martine L. M. Lamfers
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Review Article
| Open AccessA cell cycle centric view of tumour dormancy
- William A. Weston
- & Alexis R. Barr
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Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma
- Shoichi Nakamura
- , Kenoki Ohuchida
- & Masafumi Nakamura
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| Open AccessPathological complete response, category change, and prognostic significance of HER2-low breast cancer receiving neoadjuvant treatment: a multicenter analysis of 2489 cases
- Siji Zhu
- , Yujie Lu
- & Xiaosong Chen
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Surveillance after childhood cancer: are survivors with an increased risk for cardiomyopathy regularly followed-up?
- Nicolas Bougas
- , Rodrigue S. Allodji
- & Agnès Dumas
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Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers
- Yuta Kobayashi
- , Atsushi Niida
- & Koshi Mimori
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Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood
- Mark P. Little
- , Richard Wakeford
- & Martha S. Linet
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| Open AccessAscitic autotaxin as a potential prognostic, diagnostic, and therapeutic target for epithelial ovarian cancer
- Jung-A Choi
- , Hyosun Kim
- & Jae-Hoon Kim
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| Open AccessHistopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
- Magnus I. Magnusson
- , Bjarni A. Agnarsson
- & Kari Stefansson
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Focused ultrasound combined with miR-1208-equipped exosomes inhibits malignant progression of glioma
- Ying Zhan
- , Yichen Song
- & Weidong Ren
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Combined blockade of mTOR and p21-activated kinases pathways prevents tumour growth in KRAS-mutated colorectal cancer
- Stefania Belli
- , Ada Pesapane
- & Roberto Bianco
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Comment
| Open AccessTargeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity and toxicity demonstrate what lessons can be learned from this failure and where new opportunities lie.
- Nicole D. Machado
- , Lisa C. Heather
- & Geoff S. Higgins
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Review Article
| Open AccessAdvancing translational research for colorectal immuno-oncology
- Elaine M. Thomas
- , Josephine A. Wright
- & Susan L. Woods
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The changing nature of HPV associated with high grade cervical lesions in vaccinated populations, a retrospective study of over 1700 cases in Scotland
- Kate Cuschieri
- , Tim Palmer
- & Kirsty Roy
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Article
| Open AccessClassification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program
- Junseong Park
- , Jin-Kyoung Shim
- & Seok-Gu Kang
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Comprehensive analysis of the lncRNAs-related immune gene signatures and their correlation with immunotherapy in lung adenocarcinoma
- Zhengyan Yang
- , Jianling Zhu
- & Feng Lu
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| Open AccessA Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer
- Valentine M. Macaulay
- , Simon Lord
- & Johann de Bono
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Blocking of oestrogen signals improves anti-tumour effect regardless of oestrogen receptor alpha expression in cancer cells
- Nabeel Kajihara
- , Yunqi Ge
- & Ken-ichiro Seino
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