Special Feature
International Year of Chemistry
- Special Feature issue:
- August 2011 Volume 8, No 8
We celebrate the 2011 International Year of Chemistry by highlighting the important contributions of chemistry to methods currently used in biology research. Included in the special feature is a Historical Commentary on mass spectrometry, two Commentaries—one on bioorthogonal chemistry and another on fluorescent probes—a Technology Feature on protein engineering, a selection of chemistry papers published in past issues of Nature Methods, and an Editorial.
Editorial
Special Feature: International Year of Chemistry
The year of the chemist
doi:10.1038/nmeth.1667
The year 2011 has been designated the International Year of Chemistry. Nature Methods joins in the celebration with a special feature in this issue.
Abstract - | Full Text - The year of the chemist | PDF (79 KB) - The year of the chemist
Historical Commentary
Special Feature: International Year of Chemistry
A century of mass spectrometry: from atoms to proteomes
John R Yates III
doi:10.1038/nmeth.1659
Long before mass spectrometry became an important tool for cell biology, it was yielding scientific insights in physics and chemistry. Here is a brief history of how the technology has expanded from a tool for studying atomic structure and characterizing small molecules to its current incarnation as the most powerful technique for analyzing proteomes.
Abstract - | Full Text - A century of mass spectrometry: from atoms to proteomes | PDF (232 KB)
Commentary
Special Feature: International Year of Chemistry
Bringing chemistry to life
Michael Boyce & Carolyn R Bertozzi
doi:10.1038/nmeth.1657
Bioorthogonal chemistry allows a wide variety of biomolecules to be specifically labeled and probed in living cells and whole organisms. Here we discuss the history of bioorthogonal reactions and some of the most interesting and important advances in the field.
Abstract - | Full Text - Bringing chemistry to life | PDF (18,118 KB)
Special Feature: International Year of Chemistry
Fluorescent probes for sensing and imaging
Tasuku Ueno & Tetsuo Nagano
doi:10.1038/nmeth.1663
A diverse array of small molecule–based fluorescent probes is available for many different types of biological experiments. Here we examine the history of these probes and discuss some of the most interesting applications.
Abstract - | Full Text - Fluorescent probes for sensing and imaging | PDF (472 KB)
Chemistry Methods
Special Feature: International Year of Chemistry
Chemistry Methods -
doi:10.1038/nmeth0811-646
Technology Feature
Special Feature: International Year of Chemistry
Protein engineering: navigating between chance and reason -
doi:10.1038/nmeth.1654
Researchers use large libraries, focused libraries and rational design to engineer useful proteins.
Abstract - | Full Text - Protein engineering: navigating between chance and reason | PDF (321 KB)
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