Focus on cooperativity

In this issue - pv

doi:10.1038/nchembio0808-v

Full Text - In this issue | PDF (131 KB) - In this issue

Focus on cooperativity

Capturing cooperativity - p433

doi:10.1038/nchembio0808-433

Considering common definitions and mechanisms of cooperative behavior may lead to new insights into chemical and biological function.

Full Text - Capturing cooperativity | PDF (125 KB) - Capturing cooperativity

Focus on cooperativity

Cooperativity and biological complexity - pp435 - 439

Adrian Whitty

doi:10.1038/nchembio0808-435

Cooperative binding effects pervade biology. Only a few basic principles are at play, but in different biological contexts cooperativity appears in distinct guises to achieve different ends. Here I discuss some of the manifestations of cooperativity that are most important in biology and drug discovery as they pertain to systems at different levels of complexity and also highlight aspects of this broadly important phenomenon that remain poorly understood.

Full Text - Cooperativity and biological complexity | PDF (446 KB) - Cooperativity and biological complexity

Focus on cooperativity

Cutting the forest to see a single tree? - pp440 - 443

Antoine M van Oijen

doi:10.1038/nchembio0808-440

The development of single-molecule tools has significantly impacted the way we think about biochemical processes. Watching a single protein in action allows us to observe kinetic details and rare subpopulations that are hidden in ensemble-averaging techniques. I will discuss here the pros and cons of the single-molecule approach in studying ligand binding in macromolecular systems and how these techniques can be applied to characterize the behavior of large multicomponent biochemical systems.

Full Text - Cutting the forest to see a single tree? | PDF (349 KB) - Cutting the forest to see a single tree?

Focus on cooperativity

Hot springs and cool natural products - pp444 - 446

Ho Jeong Kwon, Choong Hwan Lee, Hiroyuki Osada, Minoru Yoshida & Masaya Imoto

doi:10.1038/nchembio0808-444

Abstract - Hot springs and cool natural products | Full Text - Hot springs and cool natural products | PDF (485 KB) - Hot springs and cool natural products

Focus on cooperativity

Scientists Without Borders - p447

Joanne Kotz

doi:10.1038/nchembio0808-447

A new web portal helps connect scientists and coordinate scientific efforts to address the challenges of the developing world.

Full Text - Scientists Without Borders | PDF (110 KB) - Scientists Without Borders

Focus on cooperativity

Cooperativity in macromolecular assembly - pp458 - 465

James R Williamson

doi:10.1038/nchembio.102

Abstract - Cooperativity in macromolecular assembly | Full Text - Cooperativity in macromolecular assembly | PDF (787 KB) - Cooperativity in macromolecular assembly

Focus on cooperativity

Trading molecules and tracking targets in symbiotic interactions - pp466 - 473

Eric W Schmidt

doi:10.1038/nchembio.101

Abstract - Trading molecules and tracking targets in symbiotic interactions | Full Text - Trading molecules and tracking targets in symbiotic interactions | PDF (578 KB) - Trading molecules and tracking targets in symbiotic interactions

Focus on cooperativity

Allosteric regulation and catalysis emerge via a common route - pp474 - 482

Nina M Goodey & Stephen J Benkovic

doi:10.1038/nchembio.98

Abstract - Allosteric regulation and catalysis emerge via a common route | Full Text - Allosteric regulation and catalysis emerge via a common route | PDF (1,468 KB) - Allosteric regulation and catalysis emerge via a common route