Cooperative binding effects pervade biology. Only a few basic principles are at play, but in different biological contexts cooperativity appears in distinct guises to achieve different ends. Here I discuss some of the manifestations of cooperativity that are most important in biology and drug discovery as they pertain to systems at different levels of complexity and also highlight aspects of this broadly important phenomenon that remain poorly understood.
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References
Cooper, A. & Dryden, D.T. Eur. Biophys. J. 11, 103–109 (1984).
Hilser, V.J. & Thompson, E.B. Proc. Natl. Acad. Sci. USA 104, 8311–8315 (2007).
Williams, D.H., Stephens, E., O'Brian, D.P. & Zhou, M. Angew. Chem. Int. Edn. Engl. 43, 6596–6616 (2004).
Carr, R.A., Congreve, M., Murray, C.W. & Rees, D.C. Drug Discov. Today 10, 987–992 (2005).
Hann, M.M., Leach, A.R. & Harper, G. J. Chem. Inf. Comput. Sci. 41, 856–864 (2001).
Shuker, S.B., Hajduk, P.J., Meadows, R.P. & Fesik, S.W. Science 274, 1531–1534 (1996).
Jencks, W.P. Proc. Natl. Acad. Sci. USA 78, 4046–4050 (1981).
Page, M.I. & Jencks, W.P. Proc. Natl. Acad. Sci. USA 68, 1678–1683 (1971).
Courey, A.J. Curr. Biol. 11, R250–R252 (2001).
Rocks, O. et al. Science 307, 1746–1752 (2005).
Schlee, S., Carmillo, P. & Whitty, A. Nat. Chem. Biol. 2, 636–644 (2006).
Simons, K. & Toomre, D. Nat. Rev. Mol. Cell Biol. 1, 31–39 (2000).
Dustin, M.L. Semin. Immunol. 17, 400–410 (2005).
Grakoui, A. et al. Science 285, 221–227 (1999).
Kaizuka, Y., Douglass, A.D., Varma, R., Dustin, M.L. & Vale, R.D. Proc. Natl. Acad. Sci. USA 104, 20296–20301 (2007).
Wang, S.Y. & Weiner, G. Expert Opin. Biol. Ther. 8, 759–768 (2008).
Dustin, M.L. et al. J. Biol. Chem. 282, 34748–34757 (2007).
Oltersdorf, T. et al. Nature 435, 677–681 (2005).
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Whitty, A. Cooperativity and biological complexity. Nat Chem Biol 4, 435–439 (2008). https://doi.org/10.1038/nchembio0808-435
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DOI: https://doi.org/10.1038/nchembio0808-435
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