Genetics and Genomics
|
Open Access
Featured
-
-
Translational Therapeutics
| Open AccessMethylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study
- David L Phelps
- , Jane V Borley
- & Sadaf Ghaem-Maghami
-
Translational Therapeutics
| Open AccessMultinucleated polyploidy drives resistance to Docetaxel chemotherapy in prostate cancer
- Karuna Mittal
- , Shashi Donthamsetty
- & Ritu Aneja
-
Short Communication
| Open AccessAssociation between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma
- Yae-eun Suh
- , Katherine Lawler
- & Mahvash Tavassoli
-
Molecular Diagnostics
| Open AccessSpecific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer
- Robert P Jones
- , Paul A Sutton
- & Hassan Z Malik
-
Clinical Study
| Open AccessOverall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer
- Talia Golan
- , Tal Sella
- & Steven Gallinger
-
Genetics and Genomics
| Open AccessDevelopment of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patients
- Umberto Malapelle
- , Clara Mayo de-Las-Casas
- & Giancarlo Troncone
-
Genetics and Genomics
| Open AccessEpigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer
- Hanyang Hu
- , Maoguo Shu
- & Xiaohua Chen
-
Genetics and Genomics
| Open AccessThe spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities
- Jonathan Noujaim
- , Robin L Jones
- & Khin Thway
-
Molecular Diagnostics
| Open AccessComparative mutational landscape analysis of patient-derived tumour xenografts
- Mariana Brait
- , Evgeny Izumchenko
- & David Sidransky
-
Clinical Study
| Open AccessA phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations
- J J Yang
- , Q Zhou
- & Y L Wu
-
Genetics and Genomics
| Open AccessEnrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci
- Siddhartha P Kar
- , Emily Adler
- & Kate Lawrenson
-
Genetics and Genomics
| Open AccessCYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites
- Deepti Sood
- , Nichola Johnson
- & Olivia Fletcher
-
Clinical Study
| Open AccessEGFR mutation detection in circulating cell-free DNA of lung adenocarcinoma patients: analysis of LUX-Lung 3 and 6
- Yi-Long Wu
- , Lecia V Sequist
- & James Chih-Hsin Yang
-
Clinical Study
| Open AccessChildhood neuroendocrine tumours: a descriptive study revealing clues for genetic predisposition
- I J Diets
- , I D Nagtegaal
- & M C J Jongmans
-
Clinical Study
| Open AccessNon-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment
- J L Kuiper
- , S M S Hashemi
- & E F Smit
-
Epidemiology
| Open AccessHeight, height-related SNPs, and risk of non-melanoma skin cancer
- Xin Li
- , Liming Liang
- & Jiali Han
-
Molecular Diagnostics
| Open AccessNo association of CpG island methylator phenotype and colorectal cancer survival: population-based study
- Min Jia
- , Lina Jansen
- & Michael Hoffmeister
-
Short Communication
| Open AccessOutcome of ovarian cancer after breast cancer in BRCA1 and BRCA2 mutation carriers
- Leendert H Zaaijer
- , Helena C van Doorn
- & Mieke Kriege
-
Review
| Open AccessPARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions
- G E Konecny
- & R S Kristeleit
-
Translational Therapeutics
| Open AccessGenotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients
- Siu W Lam
- , Charlotte N Frederiks
- & Epie Boven
-
Short Communication
| Open AccessCessation of targeted therapy after a complete response in BRAF-mutant advanced melanoma: a case series
- Matteo S Carlino
- , Vito Vanella
- & Paolo A Ascierto
-
Genetics and Genomics
| Open AccessGene expression profiling identifies distinct molecular subgroups of leiomyosarcoma with clinical relevance
- Yin-Fai Lee
- , Toby Roe
- & Ian Judson
-
Translational Therapeutics
| Open AccessHypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
- Marte Jonsson
- , Harald Bull Ragnum
- & Heidi Lyng
-
Clinical Study
| Open AccessOestrogen receptor status, treatment and breast cancer prognosis in Icelandic BRCA2 mutation carriers
- Jon G Jonasson
- , Olafur A Stefansson
- & Laufey Tryggvadóttir
-
Short Communication
| Open AccessAn investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer
- Bin Zhu
- , Anwesha Mukherjee
- & Nilanjan Chatterjee
-
Letter to the Editor
| Open AccessResponse to ‘Comments on 'The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study’’
- Steven A Narod
-
Letter to the Editor
| Open AccessComment on ‘The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study’
- A V Paradiso
- , M Digennaro
- & D Sambiasi
-
Letter to the Editor
| Open AccessComment on ‘The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study’
- Bernard Friedenson
-
Mini Review
| Open AccessGenetic progression of Barrett’s oesophagus to oesophageal adenocarcinoma
- Eleanor M Gregson
- , Jan Bornschein
- & Rebecca C Fitzgerald
-
Molecular Diagnostics
| Open AccessCharacterisation of PD-L1-positive subsets of microsatellite-unstable colorectal cancers
- Jung Ho Kim
- , Hye Eun Park
- & Gyeong Hoon Kang
-
Translational Therapeutics
| Open AccessDual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo
- Emiliano Cocco
- , Salvatore Lopez
- & Alessandro D Santin
-
Molecular Diagnostics
| Open AccessProspective changes in global DNA methylation and cancer incidence and mortality
- Brian T Joyce
- , Tao Gao
- & Lifang Hou
-
Molecular Diagnostics
| Open AccessA UK feasibility and validation study of the VE1 monoclonal antibody immunohistochemistry stain for BRAF-V600E mutations in metastatic melanoma
- Michelle Chin I Lo
- , Anna Paterson
- & Laszlo Igali
-
Mini Review
| Open AccessMolecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies
- Shivshankari Rajkumar
- & Ian R Watson
-
Clinical Study
| Open AccessEffects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers
- Chang Gon Kim
- , Joong Bae Ahn
- & Sang Joon Shin
-
Genetics and Genomics
| Open AccessMED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas
- Kati Kämpjärvi
- , Netta Mäkinen
- & Pia Vahteristo
-
Letter to the Editor
| Open AccessComment on ‘Wild-type APC prediction of poor prognosis in microsatellite-stable proximal colorectal cancer differs according to the age of onset’
- José Perea
- , María Arriba
- & Miguel Urioste
-
Mini Review
| Open AccessThe clinical implications of gene mutations in chronic lymphocytic leukaemia
- Davide Rossi
- & Gianluca Gaidano
-
Genetics and Genomics
| Open AccessGene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array
- Edward J Saunders
- , Tokhir Dadaev
- & Zsofia Kote-Jarai
-
Molecular Diagnostics
| Open AccessMimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation
- Ans Rombout
- , Sofie Lust
- & Jan Philippé
-
Clinical Study
| Open AccessContribution of mammography to MRI screening in BRCA mutation carriers by BRCA status and age: individual patient data meta-analysis
- Xuan-Anh Phi
- , Sepideh Saadatmand
- & Nehmat Houssami
-
Clinical Study
| Open AccessClinical impact of mutation fraction in epidermal growth factor receptor mutation positive NSCLC patients
- Petra Martin
- , Carolyn J Shiau
- & Natasha B Leighl
-
Genetics and Genomics
| Open AccessA large microRNA cluster on chromosome 19 is a transcriptional hallmark of WHO type A and AB thymomas
- Milan Radovich
- , Jeffrey P Solzak
- & Patrick J Loehrer
-
Clinical Study
| Open AccessPhase II study of necitumumab plus modified FOLFOX6 as first-line treatment in patients with locally advanced or metastatic colorectal cancer
- E Elez
- , A Hendlisz
- & J Tabernero
-
Genetics and Genomics
| Open AccessCYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk
- Xabier Garcia-Albeniz
- , Anja Rudolph
- & Jenny Chang-Claude
-
Mini Review
| Open AccessGene–environment interaction and risk of breast cancer
- Anja Rudolph
- , Jenny Chang-Claude
- & Marjanka K Schmidt
-
-
Mini Review |
The development of PARP inhibitors in ovarian cancer: from bench to bedside
- Yvette Drew
-
Clinical Study
| Open AccessEffects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial
- Maki Kawanaka
- , Jiro Watari
- & Hiroto Miwa
Browse broader subjects
Browse narrower subjects
- Agricultural genetics
- Animal breeding
- Behavioural genetics
- Cancer genetics
- Cancer genomics
- Clinical genetics
- Consanguinity
- CRISPR-Cas systems
- Cytogenetics
- Development
- Epigenetics
- Epigenomics
- Eukaryote
- Evolutionary biology
- Functional genomics
- Gene expression
- Gene regulation
- Genetic association study
- Genetic hybridization
- Genetic interaction
- Genetic linkage study
- Genetic markers
- Genome
- Genomic instability
- Genomics
- Genotype
- Haplotypes
- Heritable quantitative trait
- Immunogenetics
- Inbreeding
- Medical genetics
- Microbial genetics
- Mutation
- Neurodevelopmental disorders
- Plant breeding
- Plant genetics
- Polyploidy
- Population genetics
- Prokaryote
- Quantitative trait
- RNA splicing
- RNAi
- Sequencing