Featured
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EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity
- Fenglin Cai
- , Xiuding Yang
- & Jingyu Deng
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Article
| Open AccessCharacterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of therapy resistance, and druggable targets
- Felix Bremmer
- , Pailin Pongratanakul
- & Daniel Nettersheim
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Review Article
| Open AccessReshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
- Fengyun Zhong
- , Yilin Lin
- & Zhanlong Shen
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Review Article |
The critical roles of m6A RNA methylation in lung cancer: from mechanism to prognosis and therapy
- Mei-Ning Diao
- , Xiao-Jing Zhang
- & Yin-Feng Zhang
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Article |
STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression
- Cheng Zhang
- , Juan Wang
- & Wensheng Deng
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Article |
YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation
- Ming Zhang
- , Jue Wang
- & Changyan Ma
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Article
| Open AccessAberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer
- Maxine Umeh-Garcia
- , Henriette O’Geen
- & Colleen A. Sweeney
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Article
| Open AccessAnti-cancer therapy is associated with long-term epigenomic changes in childhood cancer survivors
- Natassia Robinson
- , John Casement
- & Gordon Strathdee
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Article |
Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
- Eijiro Shimada
- , Yoshihiro Matsumoto
- & Yasuharu Nakashima
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Article
| Open AccessRisk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping
- Stèfanie Dick
- , Frederique J. Vink
- & Johannes Berkhof
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Article |
SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis
- Jie Li
- , Ming-han Li
- & Ji-hang Yuan
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Article |
Association between risk factors, molecular features and CpG island methylator phenotype colorectal cancer among different age groups in a Taiwanese cohort
- Kuo-Hsing Chen
- , Liang-In Lin
- & Kun-Huei Yeh
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Article |
Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers
- Tsuyoshi Takashima
- , Daiki Taniyama
- & Wataru Yasui
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Article
| Open AccessEpigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia
- Timothy M. Barrow
- , Sirintra Nakjang
- & Gordon Strathdee
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Article
| Open AccessLong noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM
- Ting Li
- , Nanjing Liu
- & Xiaohou Wu
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Review Article
| Open AccessPrinciples and mechanisms of non-genetic resistance in cancer
- Charles C. Bell
- & Omer Gilan
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Review Article
| Open AccessEngaging chromatin: PRC2 structure meets function
- Paul Chammas
- , Ivano Mocavini
- & Luciano Di Croce
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Article
| Open AccessPhenotype-independent DNA methylation changes in prostate cancer
- Davide Pellacani
- , Alastair P. Droop
- & Norman J. Maitland
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Genetics and Genomics
| Open AccessAssociations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults
- Xu Gao
- , Yan Zhang
- & Hermann Brenner
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Translational Therapeutics
| Open AccessMethylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study
- David L Phelps
- , Jane V Borley
- & Sadaf Ghaem-Maghami
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Genetics and Genomics
| Open AccessOxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis
- Daniela Furlan
- , Davide Trapani
- & Tiziana Venesio
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Molecular Diagnostics
| Open AccessThe FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer
- G Y He
- , J L Hu
- & L Liang
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Molecular Diagnostics
| Open AccessNo association of CpG island methylator phenotype and colorectal cancer survival: population-based study
- Min Jia
- , Lina Jansen
- & Michael Hoffmeister
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Clinical Study
| Open AccessGenome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case–control study
- Pierre-Antoine Dugué
- , Maree T Brinkman
- & Graham G Giles
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Molecular Diagnostics
| Open AccessFAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women
- Roosmarijn Luttmer
- , Lise M A De Strooper
- & Chris J L M Meijer
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Molecular Diagnostics
| Open AccessProspective changes in global DNA methylation and cancer incidence and mortality
- Brian T Joyce
- , Tao Gao
- & Lifang Hou
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Clinical Study
| Open AccessAdverse prognostic impact of the CpG island methylator phenotype in metastatic colorectal cancer
- Yongjun Cha
- , Kyung-Ju Kim
- & Tae-You Kim
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Genetics and Genomics
| Open AccessHypermethylation of genes in testicular embryonal carcinomas
- Hoi-Hung Cheung
- , Yanzhou Yang
- & Wai-Yee Chan
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Molecular Diagnostics
| Open AccessPotential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers
- Ruth Exner
- , Walter Pulverer
- & Gerda Egger
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Molecular Diagnostics
| Open AccessSerum GADD45a methylation is a useful biomarker to distinguish benign vs malignant prostate disease
- I M Reis
- , K Ramachandran
- & R Singal
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Molecular Diagnostics
| Open AccessPTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma
- S Beg
- , A K Siraj
- & K S Al-Kuraya
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Molecular Diagnostics
| Open AccessDNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach
- A J Hubers
- , D A M Heideman
- & E Thunnissen
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Molecular Diagnostics
| Open AccessSimilar blood-borne DNA methylation alterations in cancer and inflammatory diseases determined by subpopulation shifts in peripheral leukocytes
- H Li
- , T Zheng
- & Z Guo
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Translational Therapeutics
| Open AccessMGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases
- E Nagy
- , K B Gajjar
- & D H Phillips
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Molecular Diagnostics
| Open AccessBreast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer
- I Balgkouranidou
- , M Chimonidou
- & E S Lianidou
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Genetics and Genomics
| Open AccessLINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
- S M Tajuddin
- , A F S Amaral
- & J Mosquera
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Molecular Diagnostics
| Open AccessIGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation
- E Smith
- , A R Ruszkiewicz
- & P A Drew
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Mini Review
| Open AccessReview of processing and analysis methods for DNA methylation array data
- C S Wilhelm-Benartzi
- , D C Koestler
- & R Brown
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Epidemiology
| Open AccessEpigenetic alteration: new insights moving from tissue to plasma – the example of PCDH10 promoter methylation in colorectal cancer
- E Danese
- , A M Minicozzi
- & G Lippi
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Molecular Diagnostics
| Open AccessMethylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer
- A Murata
- , Y Baba
- & H Baba
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Molecular Diagnostics
| Open AccessThe prognostic value of CDKN2A hypermethylation in colorectal cancer: a meta-analysis
- X Xing
- , W Cai
- & M Chen
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Molecular Diagnostics
| Open AccessAssessment of DNA methylation status in early stages of breast cancer development
- A Q van Hoesel
- , Y Sato
- & D S B Hoon
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Molecular Diagnostics
| Open AccessHsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
- K Gebauer
- , I Peters
- & J Serth
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Molecular Diagnostics
| Open AccessPrognostic significance of aberrantly silenced ANPEP expression in prostate cancer
- K D Sørensen
- , M O Abildgaard
- & T F Ørntoft
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Molecular Diagnostics
| Open AccessNT5E CpG island methylation is a favourable breast cancer biomarker
- C Lo Nigro
- , M Monteverde
- & T Crook
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Molecular Diagnostics
| Open AccessEven-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence
- M Truong
- , B Yang
- & D F Jarrard
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Genetics and Genomics
| Open AccessMethylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance
- J N Jeyapalan
- , D A Mohamed Noor
- & P J Scotting
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Molecular Diagnostics
| Open AccessEpidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients
- M Scartozzi
- , I Bearzi
- & S Cascinu
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Epidemiology
| Open AccessSmoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study
- Y T Ma
- , S I Collins
- & C B J Woodman