Featured
-
-
Article
| Open Access
Identification of unique rectal cancer-specific subtypes
- Batuhan Kisakol
- , Anna Matveeva
- & Jochen H. M. Prehn
-
Article
| Open Access
RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation
- Yun-Suhk Suh
- , Jieun Lee
- & Charles Lee
-
Article |
A cellular model provides insights into the pathogenicity of the oncogenic FOXL2 somatic variant p.Cys134Trp
- Laetitia Herman
- , Angélique Amo
- & Anne-Laure Todeschini
-
Article
| Open Access
A UK prospective multicentre decision impact, decision conflict and economic evaluation of the 21-gene assay in women with node+ve, hormone receptor+ve, HER2-ve breast cancer
- Simon Holt
- , Mark Verrill
- & Saira Khawaja
-
Article
| Open Access
Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
- Snehal Nirgude
- , Natali S. Sobel Naveh
- & Jennifer M. Kalish
-
Article |
Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC)
- Jimmy L. Zhao
- , Emmanuel S. Antonarakis
- & Dana Rathkopf
-
Review Article |
Acquired copy number variation in prostate tumours: a review of common somatic copy number alterations, how they are formed and their clinical utility
- Dannielle E. O’Malley
- , Kelsie Raspin
- & Liesel M. FitzGerald
-
Article |
Resistance to osimertinib in advanced EGFR-mutated NSCLC: a prospective study of molecular genotyping on tissue and liquid biopsies
- A. Leonetti
- , M. Verzè
- & M. Tiseo
-
Article
| Open Access
Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation and alterations in DNA repair: implications for therapeutic strategies
- Chloe Gulliver
- , Sebastian Huss
- & Ralf Hoffmann
-
Article
| Open Access
Hopes, concerns, satisfaction and regret in a precision medicine trial for childhood cancer: a mixed-methods study of parent and patient perspectives
- Claire E. Wakefield
- , Kate Hetherington
- & David S. Ziegler
-
Perspective
| Open Access
Redefining precision radiotherapy through liquid biopsy
- D. B. McLaren
- & T. J. Aitman
-
Article |
Comprehensive analysis of the lncRNAs-related immune gene signatures and their correlation with immunotherapy in lung adenocarcinoma
- Zhengyan Yang
- , Jianling Zhu
- & Feng Lu
-
Article
| Open Access
Genomic and evolutionary characteristics of metastatic gastric cancer by routes
- Jae Eun Lee
- , Ki Tae Kim
- & Yoon Young Choi
-
Review Article |
Radiogenomics: a key component of precision cancer medicine
- Zaoqu Liu
- , Tian Duan
- & Xinwei Han
-
Article
| Open Access
A signal-seeking Phase 2 study of olaparib and durvalumab in advanced solid cancers with homologous recombination repair gene alterations
- Subotheni Thavaneswaran
- , Maya Kansara
- & David M. Thomas
-
Article
| Open Access
Six-year experience of Australia’s first dedicated cancer of unknown primary clinic
- Arielle van Mourik
- , Gina Tonkin-Hill
- & Linda Mileshkin
-
Article
| Open Access
A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
- Rebecca Kristeleit
- , Ruth Plummer
- & Udai Banerji
-
Correspondence |
“Paradoxical neoantigenic mutations”: not simply a driver vs passenger dualism
- Xiang-Yu Meng
-
Article |
A DNA copy number alteration classifier as a prognostic tool for prostate cancer patients
- Walead Ebrahimizadeh
- , Karl-Philippe Guérard
- & Jacques Lapointe
-
Article |
Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
- Samuel V. Rasmussen
- , Agnieszka Wozniak
- & Charles Keller
-
Article |
Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma
- Lucy X. Ma
- , Yifan Wang
- & Grainne M. O’Kane
-
Article |
Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer
- Kumiko Umemoto
- , Yu Sunakawa
- & Chigusa Morizane
-
Article |
Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT
- Juran Kralj
- , Margareta Pernar Kovač
- & Anamaria Brozovic
-
Article
| Open Access
Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry
- Lisa Vermij
- , Jan J. Jobsen
- & Stephanie M. de Boer
-
Comment
| Open Access
The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care
- Maria Antonietta Cerone
- , Tara C. Mills
- & Abdullah Alvi
-
Article |
Predicting response to immune checkpoint blockade in NSCLC with tumour-only RNA-seq
- John F. Markham
- , Andrew P. Fellowes
- & Stephen B. Fox
-
Article
| Open Access
Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy
- Guadalupe A. Cifuentes
- , Adrián Santiago
- & Rubén Cabanillas
-
Article
| Open Access
An integrative approach for exploring the nature of fibroepithelial neoplasms
- Jihui Yun
- , Woohang Heo
- & Jong-Il Kim
-
Review Article |
Integrative analysis of multi-omics data for liquid biopsy
- Geng Chen
- , Jing Zhang
- & Fei Tan
-
Article |
Genome-wide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer
- Yasuyuki Okada
- , Fuduan Peng
- & Ajay Goel
-
Article
| Open Access
Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma
- Josephine Mun-Yee Ko
- , Chen Guo
- & Maria Li Lung
-
Article |
Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST
- Inga-Marie Schaefer
- , Matthew L. Hemming
- & Jonathan A. Fletcher
-
Editorial |
Biomarker testing in cancer management- can one size fit all?
- Lynette M. Sholl
- & Balazs Halmos
-
Article
| Open Access
Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank
- Harry D. Green
- , Samuel W. D. Merriel
- & Sarah E. R. Bailey
-
Article
| Open Access
Patient attrition in Molecular Tumour Boards: a systematic review
- Hannah Frost
- , Donna M. Graham
- & André Freitas
-
Article
| Open Access
Comprehensive assessment of actionable genomic alterations in primary colorectal carcinoma using targeted next-generation sequencing
- Yi-Hua Jan
- , Kien Thiam Tan
- & Alfred King-yin Lam
-
Article |
Dynamic changes in longitudinal circulating tumour DNA profile during metastatic colorectal cancer treatment
- Sheehyun Kim
- , Yoojoo Lim
- & Tae-You Kim
-
Article
| Open Access
Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing
- Melinda A. Pruis
- , Floris H. Groenendijk
- & Martijn P. Lolkema
-
Article
| Open Access
Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary
- Alicia-Marie Conway
- , Georgina C. Morris
- & Natalie Cook
-
Article
| Open Access
The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer
- Jamie Trotman
- , Ruth Armstrong
- & Patrick Tarpey
-
Article |
Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential
- Mar Giner-Calabuig
- , Seila De Leon
- & Rosa M. Xicola
-
Article
| Open Access
CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer
- Elio Adib
- , Talal El Zarif
- & Guru Sonpavde
-
Review Article
| Open Access
Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups
- Jana McHugh
- , Edward J. Saunders
- & Rosalind Eeles
-
Article |
SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer
- Takuro Matsumoto
- , Hirokazu Okayama
- & Koji Kono
-
Review Article
| Open AccessAt the dawn: cell-free DNA fragmentomics and gene regulation
- Yaping Liu
-
Article
| Open Access
A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells
- Takashi Takeda
- , Yuhki Yokoyama
- & Hirofumi Yamamoto
-
Article |
Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer
- Alex Martinez-Marti
- , Enriqueta Felip
- & Miriam Sansó
-
Article |
Multi-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes
- Marissa Iden
- , Shirng-Wern Tsaih
- & Janet S. Rader
-
Article |
NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types
- Christian Rolfo
- , Alexander Drilon
- & David R. Gandara
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance