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Open Access
Featured
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News Feature |
The rise of eco-anxiety: scientists wake up to the mental-health toll of climate change
Researchers want to unpick how climate change affects mental health around the world — from lives that are disrupted by catastrophic weather to people who are anxious about the future.
- Helen Pearson
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News |
Is ChatGPT corrupting peer review? Telltale words hint at AI use
A study of review reports identifies dozens of adjectives that could indicate text written with the help of chatbots.
- Dalmeet Singh Chawla
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Nature Podcast |
The ‘ghost roads’ driving tropical deforestation
Researchers find that a huge number of roads that don’t appear on official maps, and the protein that could determine whether someone is left-handed.
- Nick Petrić Howe
- & Benjamin Thompson
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Article |
Sex differences orchestrated by androgens at single-cell resolution
The effects of sex and androgens on the molecular programs and cellular populations are explored using a single-cell transcriptomic atlas comprising over 2.3 million cells from different tissues in Mus musculus.
- Fei Li
- , Xudong Xing
- & Dong Gao
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Article
| Open AccessFOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
Increased effectiveness of anti-cancer chimeric antigen receptor T cell therapy is associated with a stem-like phenotype through increased expression of FOXO1.
- Jack D. Chan
- , Christina M. Scheffler
- & Phillip K. Darcy
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Article
| Open AccessDistal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence
The murine enteropathogen Citrobacter rodentium targets a specific subset of absorptive intestinal epithelial cells in the mid–distal colon, which stimulate T cells to produce sustained IL-22 signals to mitigate further spread of the pathogen.
- Carlene L. Zindl
- , C. Garrett Wilson
- & Casey T. Weaver
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Article
| Open AccessFSC-certified forest management benefits large mammals compared to non-FSC
Camera-trap images of 55 mammal species in 14 logging concessions in western equatorial Africa reveal greater animal encounter rates in FSC-certified than in non-certified forests, especially for large mammals and species of high conservation priority.
- Joeri A. Zwerts
- , E. H. M. Sterck
- & Marijke van Kuijk
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Article
| Open AccessLigand efficacy modulates conformational dynamics of the µ-opioid receptor
Studies on the µ-opioid receptor using fluorescent labelling of intracellular residues and energy transfer experiments in the presence of different ligands with or without G-protein binding reveals conformational changes that correlate to ligand efficacy.
- Jiawei Zhao
- , Matthias Elgeti
- & Chunlai Chen
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Article |
Bitter taste receptor activation by cholesterol and an intracellular tastant
Cryo-electron microscopy structures of the type 2 taste receptor TAS2R14 in complex with Ggust and Gi1 identify cholesterol as an orthosteric agonist and the bitter tastant cmpd28.1 as a positive allosteric modulator and agonist.
- Yoojoong Kim
- , Ryan H. Gumpper
- & Bryan L. Roth
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Article |
Necroptosis blockade prevents lung injury in severe influenza
A newly developed RIPK3 inhibitor blocks necroptosis of lung cells, reduces lung inflammation and prevents mortality in a mouse model of influenza A virus infection.
- Avishekh Gautam
- , David F. Boyd
- & Siddharth Balachandran
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Article
| Open AccessFOXO1 is a master regulator of memory programming in CAR T cells
The transcription factor FOXO1 has a key role in human T cell memory, and manipulating FOXO1 expression could provide a way to enhance CAR T cell therapies by increasing CAR T cell persistence and antitumour activity.
- Alexander E. Doan
- , Katherine P. Mueller
- & Evan W. Weber
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Correspondence |
How to break big tech’s stranglehold on AI in academia
- Michał Woźniak
- & Paweł Ksieniewicz
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Comment |
AI can help to tailor drugs for Africa — but Africans should lead the way
Computational models that require very little data could transform biomedical and drug development research in Africa, as long as infrastructure, trained staff and secure databases are available.
- Gemma Turon
- , Mathew Njoroge
- & Kelly Chibale
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Book Review |
The comings and goings of ants: how are social skills shaped in an ever-changing world?
A colourful study of the natural history of ants that takes in dry deserts and lush forests aims to show that sociality is shaped by, and changes with, the environment.
- Seirian Sumner
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Editorial |
Rwanda 30 years on: understanding the horror of genocide
Researchers must support and elevate the voices of Rwanda’s scholars and survivors.
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Where I Work |
Digging in: last chance to save a native forest
Dario Sandrini hikes, plants and digs to save a threatened and diminishing ecosystem.
- James Mitchell Crow
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Book Review |
Survival of the nicest: have we got evolution the wrong way round?
How humans, animals and even single-celled organisms cooperate to survive suggests there’s more to life than just competition, argues a cheering study of evolutionary biology.
- Jonathan R. Goodman
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Article |
The PARTNER trial of neoadjuvant olaparib in triple-negative breast cancer
- Jean E. Abraham
- , Karen Pinilla
- & Helena M. Earl
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News Explainer |
Bird flu outbreak in US cows: why scientists are concerned
A virus that has killed hundreds of millions of birds has now infected cattle in six US states, but the threat to humans is currently low.
- Max Kozlov
- & Smriti Mallapaty
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Article |
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer
- Urszula N. Wasko
- , Jingjing Jiang
- & Kenneth P. Olive
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Technology Feature |
‘Without these tools, I’d be lost’: how generative AI aids in accessibility
A rush to place barriers around the use of artificial intelligence in academia could disproportionately affect those who stand to benefit most.
- Amanda Heidt
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Career Column |
Three ways ChatGPT helps me in my academic writing
Generative AI can be a valuable aid in writing, editing and peer review – if you use it responsibly, says Dritjon Gruda.
- Dritjon Gruda
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Career Feature |
Ready or not, AI is coming to science education — and students have opinions
As educators debate whether it’s even possible to use AI safely in research and education, students are taking a role in shaping its responsible use.
- Sarah Wells
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Article
| Open AccessConcurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
RMC-7977, a compound that exhibits potent inhibition of the active states of mutant and wild-type KRAS, NRAS and HRAS variants has a strong anti-tumour effect on RAS-addicted tumours and is well tolerated in preclinical models.
- Matthew Holderfield
- , Bianca J. Lee
- & Mallika Singh
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News |
Brazil budget cuts could leave science labs without power and water
The Lula administration is trying to reverse lawmakers’ reductions, which are hitting scientists in the Amazon especially hard.
- Rodrigo de Oliveira Andrade
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Nature Podcast |
Audio long read: Why are so many young people getting cancer? What the data say
Researchers are scrambling to explain why rates of multiple cancers are increasing among adults under the age of 50.
- Heidi Ledford
- & Benjamin Thompson
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News Feature |
After the genocide: what scientists are learning from Rwanda
Thirty years after the genocide against the Tutsi in Rwanda, Nature met with researchers who are gaining insights that could help to prevent other atrocities and enable healing.
- Nisha Gaind
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Research Highlight |
Advanced CRISPR system fixes a deadly mutation in cells
Applying a ‘base editor’ allows cells to crank out increased levels of a vital metabolic enzyme.
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Research Briefing |
Five steps to connect genetic risk variants to disease
Genetic variants contribute to the risk of developing certain diseases, but identifying the genes and molecular pathways under their control has been difficult. Now, a systematic approach to pinpointing these factors yields insights into how a specific pathway in endothelial cells influences the risk of coronary artery disease.
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Nature Podcast |
Pregnancy’s effect on ‘biological’ age, polite birds, and the carbon cost of home-grown veg
We round up some recent stories from the Nature Briefing.
- Benjamin Thompson
- , Noah Baker
- & Flora Graham
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Editorial |
Time to sound the alarm about the hidden epidemic of kidney disease
With rates rising around the world, public-health leaders must prioritize prevention, treatment, funding and data.
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Article
| Open AccessThe variation and evolution of complete human centromeres
A comparison of two complete sets of human centromeres reveals that the centromeres show at least a 4.1-fold increase in single-nucleotide variation compared with their unique flanks, and up to 3-fold variation in size, resulting from an accelerated mutation rate.
- Glennis A. Logsdon
- , Allison N. Rozanski
- & Evan E. Eichler
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Article
| Open AccessImmune microniches shape intestinal Treg function
Studies in mice show that effector T regulatory cells in the gut are most functional in the lamina propria, but this homeostatic niche is disrupted in inflammation, suggesting a spatial mechanism of tolerance to commensal microorganisms.
- Yisu Gu
- , Raquel Bartolomé-Casado
- & Fiona Powrie
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Research Briefing |
Artificial intelligence can provide accurate forecasts of extreme floods at global scale
Anthropogenic climate change is accelerating the hydrological cycle, causing an increase in the risk of flood-related disasters. A system that uses artificial intelligence allows the creation of reliable, global river flood forecasts, even in places where accurate local data are not available.
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Review Article |
Bridging structural and cell biology with cryo-electron microscopy
The interplay between cryo-electron microscopy and cryo-electron tomography to define complex macromolecular assemblies and visualize them in situ is explored.
- Eva Nogales
- & Julia Mahamid
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Article
| Open AccessImproving prime editing with an endogenous small RNA-binding protein
Genome-scale genetic screens identify the small RNA-binding protein La as a strong mediator of prime editing.
- Jun Yan
- , Paul Oyler-Castrillo
- & Britt Adamson
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News Feature |
Why loneliness is bad for your health
A lack of social interaction is linked to a higher risk of cardiovascular disease, dementia and more. Researchers are unpicking how the brain mediates these effects.
- Saima May Sidik
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News |
Diabetes drug slows development of Parkinson’s disease
The drug, which is in the same family as blockbuster weight-loss drugs such as Wegovy, slowed development of symptoms by a small but statistically significant amount.
- David Adam
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Article |
Mechanical activation opens a lipid-lined pore in OSCA ion channels
The molecular basis of OSCA/TMEM63 channel mechanosensitivity was investigated by determining 44 cryogenic electron microscopy structures of channels in different environments, expanding understanding of channel-mediated mechanotransduction and pore formation, with implications for two protein families.
- Yaoyao Han
- , Zijing Zhou
- & Yixiao Zhang
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Article
| Open AccessStructural basis of Integrator-dependent RNA polymerase II termination
Cryo-electron microscopy structures of the human Integrator complex in three different functional states shed light on how Integrator terminates RNA polymerase II (Pol II) transcription by disengaging Pol II from the DNA template.
- Isaac Fianu
- , Moritz Ochmann
- & Patrick Cramer
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Article
| Open AccessA brain-specific angiogenic mechanism enabled by tip cell specialization
A molecular mechanism for brain-specific angiogenesis operates under the control of Wnt7a/b ligands.
- Giel Schevenels
- , Pauline Cabochette
- & Benoit Vanhollebeke
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Article
| Open AccessMolecular insights into capsular polysaccharide secretion
An ensemble of cryo-electron microscopy structures of the KpsMT ABC transporter in complex with the KpsE co-polymerase and a glycolipid substrate reveal how capsular polysaccharides are recognized and translocated across bacterial cell membranes.
- Jeremi Kuklewicz
- & Jochen Zimmer
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Article |
Fossils document evolutionary changes of jaw joint to mammalian middle ear
A new morganucodontan-like species from the Jurassic in China shows evidence of a loss of load-bearing function in the articular–quadrate jaw joint, which probably had a role in the evolution of the mammalian middle ear.
- Fangyuan Mao
- , Chi Zhang
- & Jin Meng
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Article |
Jurassic shuotheriids show earliest dental diversification of mammaliaforms
A newly described fossil mammaliaform from the Jurassic period of China shows that the shuotheriids are allied to the docodonts, and provides details on the processes of tooth evolution in early mammals.
- Fangyuan Mao
- , Zhiyu Li
- & Jin Meng
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Article
| Open AccessAncestral allele of DNA polymerase gamma modifies antiviral tolerance
The POLG1 mutation p.W748S, which is associated with mitochondrial recessive ataxia syndrome, dampens innate immune responses by compromising mtDNA replisome stability, and this explains why a viral infection can trigger the development of the disease and contribute to its variable clinical manifestation.
- Yilin Kang
- , Jussi Hepojoki
- & Anu Suomalainen
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News |
Right- or left-handed? Protein in embryo cells might help decide
Gene that codes for structural protein could determine the dominant side of the human brain.
- Sumeet Kulkarni
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Correspondence |
Adopt universal standards for study adaptation to boost health, education and social-science research
- Dragos Iliescu
- & Samuel Greiff
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News & Views |
Why hand-operated front brakes were set to be the future of motoring
The complexity of fitting brakes to all four wheels of a car and the simplicity of John Maynard Smith’s ecological models, in the weekly dip into Nature’s archive.
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News |
Gut bacteria break down cholesterol — hinting at probiotic treatments
Species in the human microbiome have enzymes that can metabolize a potentially dangerous lipid.
- Julian Nowogrodzki
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