Stem cells articles within Nature

Featured

  • Research Briefing |

    Nerve cells in the human brain take a remarkably long time to mature. This study identifies an epigenetic ‘barrier’ in neural precursor cells that determines the rate of neuronal maturation and is slowly released during the process. Inhibition of the barrier is shown to accelerate maturation in multiple human stem-cell-based models.

  • Article |

    Transcriptomic and chromatin accessibility analyses of naive and transplanted colon cancer organoids in a mouse model reveal a key role for the transcription factor SOX17 in establishing a permissive immune environment for tumour cells.

    • Norihiro Goto
    • , Peter M. K. Westcott
    •  & Ömer H. Yilmaz

  • Article |

    Newly developed microfluidic neural tube-like and forebrain-like structures based on human pluripotent stem cells can model pivotal aspects of neural patterning along both the rostral–caudal and dorsal–ventral axes.

    • Xufeng Xue
    • , Yung Su Kim
    •  & Jianping Fu

  • Research Briefing |

    Human embryos are extremely difficult to study. This lack of samples limits our understanding of crucial developmental stages, such as the early formation of blood cells. A stem-cell-based model closely captures the development of human embryonic and key extra-embryonic tissues after implantation, as well as the formation of early blood cells.

  • Research Briefing |

    Early embryonic development in humans remains poorly understood. A 3D cellular model called bilaminoids, generated using ‘naive’ pluripotent stem cells and derived cell types, successfully recapitulates early development and enables mechanistic studies to examine how various cellular components interact to regulate early embryogenesis.

  • Article
    | Open Access

    A genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis captures the codevelopment of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early haematopoiesis, with potential for drug testing and disease modelling.

    • Joshua Hislop
    • , Qi Song
    •  & Mo R. Ebrahimkhani

  • Article
    | Open Access

    Authentic hypoblast cells created from naive human pluripotent stem cells (hPSCs) spontaneously assemble with naive hPSCs to form a three-dimensional bilaminar structure (bilaminoids) with a pro-amniotic-like cavity.

    • Takumi Okubo
    • , Nicolas Rivron
    •  & Yasuhiro Takashima

  • News & Views |

    Researchers have used stem cells to create models that resemble human embryos at two weeks old, but bypass the earliest developmental stages — paving the way for studies that are not possible in human embryos.

    • Naomi Moris

  • News & Views |

    The discovery that the skull has two groups of stem cell that produce similar types of descendant cell has big implications for the field of stem-cell research — and casts light on a developmental disorder that affects many children.

    • Andrei S. Chagin
    •  & Dana Trompet

  • Article
    | Open Access

    Conditional genetic ferret models enable ionocyte lineage tracing, ionocyte ablation and ionocyte-specific deletion of CFTR to elucidate the roles of pulmonary ionocyte biology and function during human health and disease.

    • Feng Yuan
    • , Grace N. Gasser
    •  & John F. Engelhardt

  • Article |

    The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.

    • Seoyeon Bok
    • , Alisha R. Yallowitz
    •  & Matthew B. Greenblatt

  • Article |

    A subpopulation of cholinergic neurons triggers Ca2+ currents among enterocytes to promote return to homeostasis after injury, and disruption of this process leads to gut inflammation and hyperplasia in Drosophila.

    • Afroditi Petsakou
    • , Yifang Liu
    •  & Norbert Perrimon

  • News & Views |

    Tumour cells tend to migrate to the vertebrae rather than to long bones, but the mechanism underlying this has been unclear. It emerges that the stem cells from which vertebrae are derived make a factor that attracts tumour cells.

    • Geert Carmeliet

  • Article
    | Open Access

    We develop a high-throughput CRISPR screening system in cerebral organoids and identify vulnerable cell types and gene regulatory networks associated with autism spectrum disorder from single-cell transcriptomes and chromatin modalities.

    • Chong Li
    • , Jonas Simon Fleck
    •  & Juergen A. Knoblich

  • Article |

    Vertebral osteoblasts in mouse and human are formed from a precursor skeletal stem cell population that is distinct from long bone skeletal stem cells in function, location and transcriptional programme.

    • Jun Sun
    • , Lingling Hu
    •  & Matthew B. Greenblatt

  • Article
    | Open Access

    The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up to 13–14 days after fertilization.

    • Bernardo Oldak
    • , Emilie Wildschutz
    •  & Jacob H. Hanna

  • Article
    | Open Access

    Epitope engineering of donor haematopoietic stem/progenitor cells endows haematopoietic lineages with selective resistance to CAR T cells or monoclonal antibodies, without affecting protein function or regulation, enabling the targeting of genes that are essential for leukaemia survival and reducing the risk of tumour immune escape.

    • Gabriele Casirati
    • , Andrea Cosentino
    •  & Pietro Genovese

  • Research Briefing |

    Cells that have been artificially reprogrammed into states similar to embryonic stem cells — known as induced pluripotent stem cells — can bear a memory of their previous history. An innovative method that incorporates a step mimicking early development yields pluripotent cells that more closely resemble those in embryos, both on a molecular and functional level.

  • Research Briefing |

    Axolotls — aquatic salamanders with an exceptional regenerative ability — rapidly increase their production of proteins in response to wounds. An axolotl-specific evolutionary divergence in a key protein called mTOR might drive this protein response and thus the regenerative potential of these amphibians, with possible implications for improving healing in mammals.

  • Article |

    Rapid activation of protein synthesis in the axolotl highlights the unanticipated impact of a translatome on orchestrating the early steps of wound healing and provides a missing link in our understanding of vertebrate regenerative potential.

    • Olena Zhulyn
    • , Hannah D. Rosenblatt
    •  & Maria Barna

  • Research Briefing |

    How the protein p53 suppresses lung cancer, the most common cause of cancer deaths worldwide, has remained unclear. It has been found that p53 impedes the development of lung cancer by promoting a highly specific cell-differentiation program that is characteristic of normal tissue regeneration after an injury.

  • Article |

    A study identifies the AT1 cell as a cell of origin for lung adenocarcinoma, and demonstrates that expression of oncogenic KRAS in differentiated AT1 cells reprograms them back into AT2 stem cells that generate indolent lepidic tumours.

    • Nicholas H. Juul
    • , Jung-Ki Yoon
    •  & Tushar J. Desai

  • Article
    | Open Access

    Co-culture of wild-type human embryonic stem cells with two types of extraembryonic-like cell engineered to overexpress specific transcription factors results in an embryoid model that recapitulates multiple features of the post-implantation human embryo.

    • Bailey A. T. Weatherbee
    • , Carlos W. Gantner
    •  & Magdalena Zernicka-Goetz

  • Article
    | Open Access

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arises from clonal (premalignant) haematopoietic precursors in the bone marrow, and BPDCN skin tumours first develop at sun-exposed anatomical sites and are distinguished by clonally expanded mutations induced by ultraviolet radiation.

    • Gabriel K. Griffin
    • , Christopher A. G. Booth
    •  & Andrew A. Lane

  • News & Views |

    In the earliest stages of mammalian development, individual cells possess the unrestricted potential to form a new organism. Researchers are closing in on the goal of growing these cells in the laboratory.

    • Martin F. Pera

  • Article |

    Glioblastoma stem cells co-opt lysine uptake and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to evade interferon-induced intrinsic effects on glioblastoma stem cell maintenance and extrinsic effects on immune response.

    • Huairui Yuan
    • , Xujia Wu
    •  & Jeremy N. Rich

  • News & Views |

    The observation that melanocyte stem cells migrate up and down the hair follicle, differentiating into melanocytes and then returning to a stem-cell identity, calls into question long-held assumptions about adult stem cells.

    • Carlos Galvan
    •  & William E. Lowry

  • Article
    | Open Access

    Local microenvironmental cues modulate melanocyte stem cells, which control hair pigmentation, to enter different differentiation states, shifting between hair follicle stem cell and transit-amplifying compartments, a process that is different to other self-renewing systems.

    • Qi Sun
    • , Wendy Lee
    •  & Mayumi Ito

  • Article |

    Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • , Jayakrishnan Gopakumar
    •  & Siddhartha Jaiswal

  • News & Views |

    A screen of mouse stem cells that exploits their propensity to gain or lose chromosomes in cell culture has been used to convert male XY to female XX cells. Subsequent differentiation generates functional eggs and live offspring.

    • Jonathan Bayerl
    •  & Diana J. Laird

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