Updated Breakthrough for systemic RNAi RNAi has become a powerful research tool, but progress...[more]

Updated Designer plant miRNAs meet their targets RNAi is widely used to knock down gene expression in...[more]

Updated Behind the scenes In the past decade there has been a surge of interest in microRNAs...[more]

Updated No escape from micromanagement MicroRNAs (miRNAs) have emerged as important...[more]

Updated Small RNAs cross the divide One of the properties that make stem cells special is...[more]

RISC assessment The RNase III Dicer enzyme processes RNAs into small interfering (si)RNAs and micro (mi)RNAs...[more]

Let us join together in silence It's so often the case – processes that were previously considered separate and distinct turn out to be intimately related...[more]

Eight steps to silence
Knowing how best to design small interfering RNAs (siRNAs) for RNA interference (RNAi) studies makes the difference...[more]

Building the complete toolkit
Two groups have independently developed a general way of generating RNA interference (RNAi) libraries...[more]

Silencing the sceptics
We've all heard of the promise of RNA interference (RNAi) as a potential approach to treating disease...[more]

RNA stories on a mythical scale
RNA interference (RNAi) hardly disappears off the science headlines...[more]

From the Nature Reviews editors
Full Text | PDF

Updated
Building mammalian signalling pathways with RNAi screens
Jason Moffat and David M. Sabatini
Abstract | Full Text | PDF

Updated
High-throughput RNAi screening in cultured cells: a user's guide
Christophe J. Echeverri and Norbert Perrimon
Abstract | Full Text | PDF

RNAi-mediated pathways in the nucleus
Marjori A. Matzke and James A. Birchler
Abstract | Full Text | PDF

Improving the efficiency of RNA interference in mammals Vivek Mittal Abstract | Full Text | PDF

Gene discovery by ribozyme and siRNA libraries
Hideo Akashi, Sahohime Matsumoto and Kazunari Taira
Abstract | Full Text | PDF

siRNAs: applications in functional genomics and potential as therapeutics
Yair Dorsett and Thomas Tuschl
Abstract | Full Text | PDF

Updated
The principles of guiding by RNA: chimeric RNA-protein enzymes
Alexander H�ttenhofer and Peter Schattner
Abstract | Full Text | PDF

RNAi and its applications
Ren� Ketting and Ronald Plasterk
PDF