Sigma-Aldrich: Your Source for RNA Interference Solutions

Over the course of a few short years RNA Interference has grown from an interesting observation to an essential research tool in both industry and academia. The mission of Sigma-Aldrich is to make this tool available to researchers worldwide. Whether you chose to perform your experiments using synthetic RNA or vector based shRNA we have the solution for your needs.

MISSION shRNA Libraries: As a sponsoring member of The RNAi Consortium (TRC) Sigma-Aldrich produces and distributes the lentivirus-based MISSION TRC shRNA Libraries consisting of 15,000 human gene targets (MISSION TRC-Hs1.0) and 15,000 mouse gene targets (MISSION TRC-Mm1.0). This renewable lentiviral system allows transduction of primary and non-dividing cells, as well as providing the ability to perform transient or stable silencing. The libraries are available in multiple formats - bacterial glycerol stocks, purified plasmid DNA, and lentiviral particles.

Custom siRNA: Sigma-Proligo provides ready-to-use, high quality, desalted and purified custom siRNA. Our capacity ranges from microgram to multi-gram in either single strand or duplex siRNA and includes a broad range of modifications. Rapid turn around time is achieved with our high-throughput capability. We are fully licensed and offer competitive pricing.