Nature Reviews Neuroscience
Volume 10, No 12 December 2009
Featured Article
Plasticity during stroke recovery: from synapse to behaviour
Timothy H. Murphy & Dale Corbett
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Current Issue
Review
TrkB signalling pathways in LTP and learning
Liliana Minichiello
In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways downstream of TrkB activation that might contribute to this function.
Current Issue
Review
Plasticity and stability of visual field maps in adult primary visual cortex
Brian A. Wandell & Stelios M. Smirnakis
Primary visual cortex (V1) is often used as a prime example of cortical plasticity both during development and in adulthood. In this provocative Review, Wandell and Smirnakis reassess the literature and discuss the evidence for and against plasticity in adult V1.
Current Issue
Opinion
A new perspective on the role of the orbitofrontal cortex in adaptive behaviour
Geoffrey Schoenbaum, Matthew R. Roesch, Thomas A. Stalnaker & Yuji K. Takahashi
The orbitofrontal cortex has a role in flexible behaviour. Schoenbaum and colleagues discuss recent data suggesting that it signals expected outcomes and propose that this role also explains how it can mediate flexible behaviour in the face of unexpected outcomes.
Current Issue
Progress
Understanding microRNAs in neurodegeneration
Stephen M. Eacker, Ted M. Dawson & Valina L. Dawson
Multiple roles for microRNA-mediated regulation of mRNA translation in the nervous system have emerged in recent years. Dawson and colleagues discuss the mechanisms by which microRNAs might influence neurodegenerative disease pathogenesis and outline key questions for future research.
Current Issue
Research Highlights
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Development:
Initiation of a new connection
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Neurogenesis:
A mother–daughter relationship
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Neural coding:
Oscillations help to decode spike patterns
Focus issue
CNS evolution
This focus issue — sponsored by the Wellcome Trust — celebrates the contribution of Darwin's ideas to our current understanding of the evolution of the nervous system. It includes articles that discuss the molecular, cellular and structural changes that have contributed to CNS evolution, and their functional consequences.
Gain free access to this issue until 31st March 2010 here
More Neuroscience
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Recommended Links
Links recommended by the editors
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Neuropod
Neuroscience podcast from Nature
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Web Focus Collection
Selected articles from the Nature Publishing Group
Noticeboard
Focus on Neuroimmunology
Understanding the crosstalk between the nervous and immune systems and how it can be dysregulated provides us with crucial insights necessary for the treatment of neurological diseases such as multiple sclerosis and Alzheimer's disease. Nature Reviews Immunology presents a special Focus issue featuring articles that review our current understanding of the immunopathogenesis of and emergent immunotherapies for these neurological diseases.
Focus on Stress
The body's response to stress has adaptive value, but exposure to chronic or severe stress — which is not uncommon in humans — can have long–lasting effects on brain structure and function, which can lead to changes in cognition and to disorders such as depression and post–traumatic stress disorder. This Focus issue highlights recent developments in this field, with a view to understanding the mechanisms that trigger and mediate stress responses, which will enable the development of therapeutic strategies aimed at treating stress–related disorders.
CNS precursors series
A series of articles highlighting recent advances in the identification of precursor cells and in our understanding of their regulation and functional roles.
Sleep series
A series of articles highlighting the genetic, cellular and systems basis of sleep and the importance of sleep for cognitive function and mental health.
Neuron–glia interactions series
A series of articles highlighting the interactions between different types of glia and neurons at the cellular and network levels.
Memory systems series
A special series of articles highlighting different types of memory and how they are represented in the brain.
Signalling in development series
A special series of articles highlighting recent progress in our understanding of the molecular mechanisms that are involved in all aspects of neural development.
Neuroimaging series
A special series of articles highlighting applications of neuroimaging techniques in all areas of neuroscience, including basic neurobiology, cognitive and behavioural neuroscience, translational neurology and clinical practice.
2008 Journal Citation Report (Thomson Reuters, 2009)
