Cancer origins

A series of Review and Perspective articles

Latest Reviews

  • Consensus Statement | | open

    Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four evolutionary and ecological processes: neoplastic cell diversity and changes over time in that diversity, hazards to cell survival and available resources.

    • Carlo C. Maley
    • , Athena Aktipis
    • , Trevor A. Graham
    • , Andrea Sottoriva
    • , Amy M. Boddy
    • , Michalina Janiszewska
    • , Ariosto S. Silva
    • , Marco Gerlinger
    • , Yinyin Yuan
    • , Kenneth J. Pienta
    • , Karen S. Anderson
    • , Robert Gatenby
    • , Charles Swanton
    • , David Posada
    • , Chung-I Wu
    • , Joshua D. Schiffman
    • , E. Shelley Hwang
    • , Kornelia Polyak
    • , Alexander R. A. Anderson
    • , Joel S. Brown
    • , Mel Greaves
    •  & Darryl Shibata
  • Review |

    This Review by Corbet and Feron summarizes recent data showing that tumour acidosis influences cancer metabolism and contributes to cancer progression; it also highlights advances in therapeutic modalities aimed at either inhibiting or exploiting tumour acidification.

    • Cyril Corbet
    •  & Olivier Feron
  • Erratum |

    • Annette T. Byrne
    • , Denis G. Alférez
    • , Frédéric Amant
    • , Daniela Annibali
    • , Joaquín Arribas
    • , Andrew V. Biankin
    • , Alejandra Bruna
    • , Eva Budinská
    • , Carlos Caldas
    • , David K. Chang
    • , Robert B. Clarke
    • , Hans Clevers
    • , George Coukos
    • , Virginie Dangles-Marie
    • , S. Gail Eckhardt
    • , Eva Gonzalez-Suarez
    • , Els Hermans
    • , Manuel Hidalgo
    • , Monika A. Jarzabek
    • , Steven de Jong
    • , Jos Jonkers
    • , Kristel Kemper
    • , Luisa Lanfrancone
    • , Gunhild Mari Mælandsmo
    • , Elisabetta Marangoni
    • , Jean-Christophe Marine
    • , Enzo Medico
    • , Jens Henrik Norum
    • , Héctor G. Palmer
    • , Daniel S. Peeper
    • , Pier Giuseppe Pelicci
    • , Alejandro Piris-Gimenez
    • , Sergio Roman-Roman
    • , Oscar M. Rueda
    • , Joan Seoane
    • , Violeta Serra
    • , Laura Soucek
    • , Dominique Vanhecke
    • , Alberto Villanueva
    • , Emilie Vinolo
    • , Andrea Bertotti
    •  & Livio Trusolino
  • Review |

    Understanding how high-risk multiple myeloma evolves from more therapeutically tractable stages is crucial for improving outcomes for patients. This Review discusses the evolution of high-risk disease, how it may be diagnosed and how this might improve treatment.

    • Charlotte Pawlyn
    •  & Gareth J. Morgan

News & Comment

  • Research Highlight |

    Vitamin C supplementation has shown limited benefits in patients with solid tumours. Two studies report that vitamin C supplementation can reduce Tet-dependent leukaemia progression in mice, supporting the concept of high-dose vitamin C supplementation in certain patients with haematological malignancies.

    • Ulrike Harjes
  • Research Highlight |

    Although speckle-type POZ protein (SPOP) is the most frequently mutated gene in primary prostate cancer, its therapeutic implications are incompletely understood. Now, three studies describe mechanisms of resistance to bromodomain and extraterminal (BET) protein inhibitors in SPOP-mutated prostate cancer.

    • Conor A. Bradley
  • Research Highlight |

    Both obesity and systemic inflammation promote cancer progression, although how obesity-associated inflammation affects cancer metastasis is poorly understood. Quail et al. now show that obesity induces cytokines that stimulate lung neutrophilia in mice, thereby promoting breast cancer metastasis.

    • Ulrike Harjes
  • Research Highlight |

    Since mesenchymal-like properties in cancer cells are often associated with therapy resistance, Viswanathan et al. explored vulnerabilities of these cells. They identified an enzyme of the lipid peroxidase pathway, inhibition of which caused ferroptosis in a range of cancer types.

    • Ulrike Harjes
  • Research Highlight |

    A new study has looked at the evolutionary origins of lymphatic and distant metastases in human colorectal cancer and found that, in most cases, cancer spread to lymph nodes is not a precursor for seeding of cancer cells to other organs.

    • Anna Dart

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