Nature Reviews Cancer
Volume 9, No 12 December 2009
Featured Article
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown, Sonia Lain, Chandra S. Verma, Alan R. Fersht & David P. Lane
Main pages for finding content:
Current Issue
Review
Article series:
MYC
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
Tracy A. Brooks & Laurence H. Hurley
Transcription–induced DNA supercoiling has dynamic effects on the MYC promoter element: it converts duplex DNA to non–duplex DNA structures. These non–duplex DNA structures regulate transcription and are amenable to small–molecule targeting. Does this represent another opportunity for the treatment of tumours?
Current Issue
Review
Mucins in cancer: function, prognosis and therapy
Donald W. Kufe
The mucin family of transmembrane and secreted glycoproteins form a barrier that protects the epithelium. Mucins affect epithelial polarity, inflammation, and cell growth and survival signalling; all of these functions could have roles in tumour formation and progression. This Review highlights the functions of mucins in cancer and discusses how these proteins are being targeted therapeutically.
Current Issue
Review
Metabolism and cancer: the circadian clock connection
Saurabh Sahar & Paolo Sassone–Corsi
Evidence indicates that the disruption of the circadian clock might be directly linked to cancer. As described here, alterations in clock function could lead to aberrant cellular proliferation, DNA damage responses and altered metabolism.
Current Issue
Perspective
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Sharad Kumar
Recent evidence suggests that caspase 2 may have multiple roles in the response to DNA damage, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis and the treatment of cancer.
Current Issue
Research Highlights
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Tumour microenvironment:
External influences
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Pancreatic cancer:
On your marks...
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Cell migration:
The benefit of being single
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Signalling:
A Ras and NF–κB pas de deux
More Cancer
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Web Focus Collection
Selected articles from the Nature Publishing Group including focuses on microRNAs and cancer and on stem cells
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Recommended Links
Selected articles from Nature
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Conferences
A calendar of forthcoming meetings and workshops from across the field of cancer.
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Migration and metastasis
A selection of Research Highlights, News and Views, Progress, Reviews, Perspectives and Research Articles published by Nature Publishing Group journals on the topic of migration and metastasis.
Noticeboard
Hypoxia and metabolism
This Nature Reviews Cancer Collection on Hypoxia and metabolism includes a selection of recent Reviews, Perspectives and Research Highlights that provide insight into the roles of these processes in tumour biology and therapy.
Pathway Interaction Database
For a visual, up–to–date view of the proteins and genes that interact with and regulate p53.
Nature Reports Stem Cells
Nature Reports Stem Cells for the latest news, research, comment and analysis about stem cells and their implications.
MYC
Throughout 2008 and 2009, we will publish a series of specially commissioned articles that discuss the key issues and our current knowledge of MYC and cancer.
What is translational cancer research?
What does translational cancer research mean to you? Compare your views with those of our podcast panel from the new Cancer Research UK Cambridge Research Institute.
Bruce Ponder, Fiona Watt, Duncan Odom & David Neal
Mouse models
The evolution of genetically engineered mouse models of cancer
Kristopher K. Frese and David A. Tuveson
Tumour Microenvironment
The final two articles in our series on the tumour microenvironment are published in this month�s issue. All the articles that have appeared in this series can be found online at www.nature.com/nrc/series/tumourmicro
Milestones in Cancer
Milestones in Cancer is a collaborative project involving three journals - Nature, Nature Medicine and Nature Reviews Cancer - and celebrates more than 100 years of discoveries in the field of cancer.
Nature Reviews Genetics Wiki
Nature Reviews Genetics presents a first for Nature Publishing Group — a Review that can be commented on, updated, and added to by readers using Wiki features. The Review explores the past, present and future of the biology cyberinfrastructure.
2008 Journal Citation Report (Thomson Reuters, 2009)
