Dissecting self-renewal in stem cells with RNA interference
Natalia Ivanova, Radu Dobrin, Rong Lu, Iulia Kotenko, John Levorse, Christina DeCoste, Xenia Schafer, Yi Lun and Ihor R. Lemischka
Nature 24, 89-94 2006
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A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Yousang Gwack, Sonia Sharma, Julie Nardone, Bogdan Tanasa, Alina Iuga, Sonal Srikanth, Heidi Okamura, Diana Bolton, Stefan Feske, Patrick G. Hogan and Anjana Rao
Nature 441, 646-650 2006
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RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse
Minoo Rassoulzadegan, Valérie Grandjean, Pierre Gounon, Stéphane Vincent, Isabelle Gillot and François Cuzin
Nature 441, 469-474 2006
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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar and Mark A. Kay
Nature 441, 537-541 2006
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A loss-of-function RNA interference screen for molecular targets in cancer
Vu N. Ngo, R. Eric Davis, Laurence Lamy, Xin Yu, Hong Zhao, Georg Lenz, Lloyd T. Lam, Sandeep Dave, Liming Yang, John Powell and Louis M. Staudt
Nature 441, 106-110 2006
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RNAi-mediated gene silencing in non-human primates
Tracy S. Zimmermann, Amy C. H. Lee, Akin Akinc, Birgit Bramlage, David Bumcrot, Matthew N. Fedoruk, Jens Harborth, James A. Heyes, Lloyd B. Jeffs, Matthias John, Adam D. Judge, Kieu Lam, Kevin McClintock, Lubomir V. Nechev, Lorne R. Palmer, Timothy Racie, Ingo Röhl, Stephan Seiffert, Sumi Shanmugam, Vandana Sood, Jürgen Soutschek, Ivanka Toudjarska, Amanda J. Wheat, Ed Yaworski, William Zedalis, Victor Koteliansky, Muthiah Manoharan, Hans-Peter Vornlocher and Ian MacLachlan
Nature 441, 111-114 2006
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Identification of pathways regulating cell size and cell-cycle progression by RNAi
Mikael Björklund, Minna Taipale, Markku Varjosalo, Juha Saharinen, Juhani Lahdenperä and Jussi Taipale
Nature 439, 1009-1013 2006
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Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans
R. Lu, M. Maduro, F. Li, H. W. Li, G. Broitman-Maduro, W. X. Li & S. W. Ding
Nature 436, 1040-1043 2005
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Identification of JAK/STAT signalling components by genome-wide RNA interference
Patrick Mller, David Kuttenkeuler, Viola Gesellchen, Martin P. Zeidler & Michael Boutros
Nature 436, 871-875 2005
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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
Thimmaiah P. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy, Jessica Norman, Neil Cooch, Kazuko Nishikura & Ramin Shiekhattar
Nature 436, 740-744 2005
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RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription
Vera Schramke, Daniel M. Sheedy, Ahmet M. Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon & Robin C. Allshire
Nature 435, 1275-1279 2005
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Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
B. Snnichsen, L. B. Koski, A. Walsh, P. Marschall, B. Neumann, M. Brehm, A.-M. Alleaume, J. Artelt, P. Bettencourt, E. Cassin, M. Hewitson, C. Holz, M. Khan, S. Lazik, C. Martin, B. Nitzsche, M. Ruer, J. Stamford, M. Winzi, R. Heinkel, M. Rder, J. Finell, H. Hntsch, S. J. M. Jones, M. Jones, F. Piano, K. C. Gunsalus, K. Oegema, P. Gnczy, A. Coulson, A. A. Hyman & C. J. Echeverri
Nature 434, 462-469 2005
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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jrgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Rhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan & Hans-Peter Vornlocher
Nature 432, 173-178 2004
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Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
Hiroaki Kawasaki & Kazunari Taira
Nature 431, 211-217 2004
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A large-scale RNAi screen in human cells identifies new components of the p53 pathway
Katrien Berns, E. Marielle Hijmans, Jasper Mullenders, Thijn R. Brummelkamp, Arno Velds, Mike Heimerikx, Ron M. Kerkhoven, Mandy Madiredjo, Wouter Nijkamp, Britta Weigelt, Reuven Agami, Wei Ge, Guy Cavet, Peter S. Linsley, Roderick L. Beijersbergen & Ren Bernards
Nature 428, 431-437 2004
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A resource for large-scale RNA-interference-based screens in mammals
Patrick J. Paddison, Jose M. Silva, Douglas S. Conklin, Mike Schlabach, Mamie Li, Shola Aruleba, Vivekanand Balija, Andy O'Shaughnessy, Lidia Gnoj, Kim Scobie, Kenneth Chang, Thomas Westbrook, Michele Cleary, Ravi Sachidanandam, W. Richard McCombie, Stephen J. Elledge & Gregory J. Hannon
Nature 428, 427-431 2004
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Spatially restricted microRNA directs leaf polarity through ARGONAUTE1
Catherine A. Kidner & Robert A. Martienssen
Nature 428, 81–84  2004
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microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity
Michelle T. Juarez, Jonathan S. Kui, Julie Thomas, Bradley A. Heller & Marja C. P. Timmermans
Nature 428, 84–88  2004
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A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
Scott Kennedy, Duo Wang & Gary Ruvkun
Nature 427, 645-649 2004
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Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi
Titia Sijen & Ronald H. A. Plasterk
Nature 426, 310–314  2003
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Structure and conserved RNA binding of the PAZ domain
Kelley S. Yan, Sherry Yan, Amjad Farooq, Arnold Han, Lei Zeng & Ming-Ming Zhou
Nature 426, 468–474  2003
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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain
Andreas Lingel, Bernd Simon, Elisa Izaurralde & Michael Sattler
Nature 426, 465–469  2003
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The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee, Chiyoung Ahn, Jinju Han, Hyounjeong Choi, Jaekwang Kim, Jeongbin Yim, Junho Lee, Patrick Provost, Olof Radmark, Sunyoung Kim & V. Narry Kim
Nature 425, 415–429  2003
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A micrococcal nuclease homologue in RNAi effector complexes
Amy A. Caudy, RenÉ F. Ketting, Scott M. Hammond, Ahmet M. Denli, Anja M. P. Bathoorn, Bastiaan B. J. Tops, Jose M. Silva, Mike M. Myers, Gregory J. Hannon & Ronald H. A. Plasterk
Nature 425, 411–414  2003
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Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
Kaveh Ashrafi, Francesca Y. Chang, Jennifer L. Watts, Andrew G. Fraser, Ravi S. Kamath, Julie Ahringer & Gary Ruvkun
Nature 421, 268–272  2003
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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Ravi S. Kamath, Andrew G. Fraser, Yan Dong, Gino Poulin, Richard Durbin, Monica Gotta, Alexander Kanapin, Nathalie Le Bot, Sergio Moreno, Marc Sohrmann, David P. Welchman, Peder Zipperlen & Julie Ahringer
Nature 421, 231–237  2003
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Gene expression
RNA interference in adult mice
Anton P. McCaffrey, Leonard Meuse, Thu-Thao T. Pham, Douglas S. Conklin, Gregory J. Hannon & Mark A. Kay
Nature 418, 38–39  2002
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Modulation of HIV-1 replication by RNA interference
Jean-Marc Jacque, Karine Triques & Mario Stevenson
Nature 418, 435–438  2002
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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel, Abdullah Yalcin, Klaus Weber & Thomas Tuschl
Nature 411, 494–498  2001
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Role for a bidentate ribonuclease in the initiation step of RNA interference
Emily Bernstein, Amy A. Caudy, Scott M. Hammond & Gregory J. Hannon Nature 411, 363–366  2001
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Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Andrew G. Fraser, Ravi S. Kamath, Peder Zipperlen, Maruxa Martinez-Campos, Marc Sohrmann & Julie Ahringer
Nature 408, 325–330  2000
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A genetic link between co-suppression and RNA interference in C. elegans
René F. Ketting & Ronald H. A. Plasterk
Nature 404, 296–298  2000
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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
Scott M. Hammond, Emily Bernstein, David Beach & Gregory J. Hannon
Nature 404, 293–2986  2000
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RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines
Daniel P Cioca, Yuji Aoki & Kendo Kiyosawa
Cancer Gene Therapy 10, 125–133  2003
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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector
Marc van de Wetering, Irma Oving, Vanesa Muncan, Menno Tjon Pon Fong, Helen Brantjes, Dik van Leenen, Frank C.P. Holstege, Thijn R. Brummelkamp, Reuven Agami & Hans Clevers
EMBO reports 4, 609–615  2003
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Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs
Takanori Yokota, Naoya Sakamoto, Nobuyuki Enomoto, Yoko Tanabe, Makoto Miyagishi, Shinya Maekawa, Li Yi, Masayuki Kurosaki, Kazunari Taira, Mamoru Watanabe & Hidehiro Mizusawa
EMBO reports 4, 602–608  2003
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Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells
W.-S. Park, M. Hayafune, N. Miyano-Kurosaki1 & H. Takaku1
Gene Therapy 24, 2046–2050  2003
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Short hairpin RNA-expressing bacteria elicit RNA interference in mammals
Shuanglin Xiang, Johannes Fruehauf & Chiang J Li
Nature Biotechnology 24, 697-702 2006
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A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference
Selda Samakoglu, Leszek Lisowski, Tulin Budak-Alpdogan, Yelena Usachenko, Santina Acuto, Rosalba Di Marzo, Aurelio Maggio, Ping Zhu, John F. Tisdale, Isabelle Rivière & Michel Sadelain
Nature Biotechnology 24, 89-94 2005
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Design of a genome-wide siRNA library using an artificial neural network
Dieter Huesken, Joerg Lange, Craig Mickanin, Jan Weiler, Fred Asselbergs, Justin Warner, Brian Meloon, Sharon Engel, Avi Rosenberg, Dalia Cohen, Mark Labow, Mischa Reinhardt, Franois Natt & Jonathan Hall
Nature Biotechnology 23, 995-1001 2005
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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
David V Morrissey, Jennifer A Lockridge, Lucinda Shaw, Karin Blanchard, Kristi Jensen, Wendy Breen, Kimberly Hartsough, Lynn Machemer, Susan Radka, Vasant Jadhav, Narendra Vaish, Shawn Zinnen, Chandra Vargeese, Keith Bowman, Chris S Shaffer, Lloyd B Jeffs, Adam Judge, Ian MacLachlan & Barry Polisky
Nature Biotechnology 23, 1002-1007 2005
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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
Erwei Song, Pengcheng Zhu, Sang-Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi Feng, Deborah Palliser, David B Weiner, Premlata Shankar, Wayne A Marasco & Judy Lieberman
Nature Biotechnology 23, 709-717 2005
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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
Adam D Judge, Vandana Sood, Janet R Shaw, Dianne Fang, Kevin McClintock & Ian MacLachlan
Nature Biotechnology 23, 457-462 2005
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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
Dong-Ho Kim, Mark A Behlke, Scott D Rose, Mi-Sook Chang, Sangdun Choi & John J Rossi
Nature Biotechnology 23, 222-226 2004
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Synthetic shRNAs as potent RNAi triggers
Despina Siolas, Cara Lerner, Julja Burchard, Wei Ge, Peter S Linsley, Patrick J Paddison, Gregory J Hannon & Michele A Cleary
Nature Biotechnology 23, 227-231 2004
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Lack of interferon response in animals to naked siRNAs
Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche & Mark E Davis
Nature Biotechnology 22, 1579-1582 2004
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Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
Dong-Ho Kim, Michael Longo, Young Han, Patric Lundberg, Edouard Cantin & John J Rossi
Nature Biotechnology 22, 321-325 2004
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Rational siRNA design for RNA interference
Angela Reynolds, Devin Leake, Queta Boese, Stephen Scaringe, William S Marshall & Anastasia Khvorova
Nature Biotechnology 22, 326-330 2004
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Expression profiling reveals off-target gene regulation by RNAi
Aimee L Jackson, Steven R Bartz, Janell Schelter, Sumire V Kobayashi, Julja Burchard, Mao Mao, Bin Li, Guy Cavet & Peter S Linsley
Nature Biotechnology 21, 635–637  2003
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Inhibition of hepatitis B virus in mice by RNA interference
Anton P McCaffrey, Hiroyuki Nakai, Kusum Pandey, Zan Huang, Felix H Salazar, Hui Xu, Stefan F Wieland, Patricia L Marion & Mark A Kay
Nature Biotechnology 21, 639–644  2003
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Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype
Tilo Kunath, Gerald Gish, Heiko Lickert, Nina Jones, Tony Pawson & Janet Rossant
Nature Biotechnology 21, 559–561  2003
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Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing
Jason W. Myers, Joshua T. Jones, Tobias Meyer & James E. Ferrell
Nature Biotechnology 21, 324–328  2003
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Screening for gene function in chicken embryo using RNAi and electroporation
Vladimir Pekarik, Dimitris Bourikas, Nicola Miglino, Pascal Joset, Stephan Preiswerk & Esther T. Stoeckli
Nature Biotechnology 21, 93–96  2002
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Effective expression of small interfering RNA in human cells
Cynthia P. Paul, Paul D. Good, Ira Winer & David R. Engelke
Nature Biotechnology 20, 505–508  2002
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Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells
Nan Sook Lee, Taikoh Dohjima, Gerhard Bauer, Haitang Li, Ming-Jie Li, Ali Ehsani, Paul Salvaterra & John Rossi
Nature Biotechnology 20, 500–505  2002
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U6 promoter–driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells
Makoto Miyagishi & Kazunari Taira
Nature Biotechnology 20, 497–500  2002
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Heritable gene silencing in Drosophila using double-stranded RNA
Jason R. Kennerdell & Richard W. Carthew
Nature Biotechnology 18, 896–898  2000
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Activation of the interferon system by short interfering RNAs
C. A. Sledz, M. Holko, M. J.  de Veer, R. H.  Silverman & B. R. G.  Williams
Nature Cell Biology 5, 834–839  2003
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Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning
Ian R Henderson, Xiaoyu Zhang, Cheng Lu, Lianna Johnson, Blake C Meyers, Pamela J Green & Steven E Jacobsen
Nature Genetics 38, 721-725 2006
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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes
Stephan Kissler, Patrick Stern Kazue Takahashi, Kara Hunter, Laurence B Peterson & Linda S Wicker
Nature Genetics 38, 479-483 2006
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Induction, suppression and requirement of RNA silencing pathways in virulent Agrobacterium tumefaciens infections
Patrice Dunoyer, Christophe Himber & Olivier Voinnet
Nature Genetics 38, 258-263 2006
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DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal
Patrice Dunoyer, Christophe Himber & Olivier Voinnet