Perspectives
Nature Reviews Cancer 3, 781-789 (October 2003) | doi:10.1038/nrc1191
Innovation: New tools for functional mammalian cancer genetics
Thijn R. Brummelkamp1 & René Bernards1 About the authors
Abstract
Knowledge of the function of individual genes that encode components of cell-signalling pathways is crucial to our understanding of normal growth control and its deregulation in cancer, but we have functional information for only 
15% of human genes at present. Several new technologies have recently become available to identify gene function in mammalian cells using high-throughput genetic screens. These new tools will make it possible to identify new and innovative classes of anticancer drugs, including those that show synthetic lethal interactions with cancer-specific mutations.
Author affiliations
- Thijn R. Brummelkamp and René Bernards are at the Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Correspondence to: René Bernards1 Email: r.bernards@nki.nl
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