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Nature Reviews Cancer 3, 781–789 (1 October 2003) | doi:10.1038/nrc1191
New tools for functional mammalian cancer genetics
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Abstract
Knowledge of the function of individual genes that encode components of cell-signalling pathways is crucial to our understanding of normal growth control and its deregulation in cancer, but we have functional information for only |[sim]|15% of human genes at present. Several new technologies have recently become available to identify gene function in mammalian cells using high-throughput genetic screens. These new tools will make it possible to identify new and innovative classes of anticancer drugs, including those that show synthetic lethal interactions with cancer-specific mutations.
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