Early life immunology

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Latest Reviews

  • Review |

    Here, the authors introduce the idea that a spectrum of metabolic states of immune cells can provide a basis for categorizing human diseases. They explore the metabolic and interlinked signalling requirements of T cells responding to acute infection and how metabolic reprogramming of T cells is linked to disease.

    • Glenn R. Bantug
    • , Lorenzo Galluzzi
    • , Guido Kroemer
    •  & Christoph Hess
  • Review |

    γδ T cells are found mainly in epithelial tissues, where they have crucial roles in tissue homeostasis and repair. Here, the authors describe how γδ T cells are activated and regulated in epithelial tissues, such as the skin and intestine, to mediate host microbial tolerance and provide protection against infection.

    • Morten M. Nielsen
    • , Deborah A. Witherden
    •  & Wendy L. Havran
  • Review |

    This Review focuses on how the complement cascade can both promote and inhibit antitumour immune responses. The authors discuss the potential of targeting complement components for immunotherapeutic purposes in patients with cancer.

    • Edimara S. Reis
    • , Dimitrios C. Mastellos
    • , Daniel Ricklin
    • , Alberto Mantovani
    •  & John D. Lambris
  • Review |

    Tissue-resident eosinophils selectively secrete cytokines and other mediators that have diverse functions in health and disease.

    • Peter F. Weller
    •  & Lisa A. Spencer
  • Review |

    Here, the authors discuss the role of cellular barriers in establishing immune privilege, both in the intestine and in other organs, such as the brain and the eyes. They compare protective epithelial and vascular barriers in different organs and examine how several pathologies are linked to the disruption of these barriers.

    • Ilaria Spadoni
    • , Giulia Fornasa
    •  & Maria Rescigno
  • Review |

    In this Review, the authors describe how type 2 immune responses drive tissue repair and fibrosis. They explain how these responses are crucial for repairing damaged tissue but can also lead to pathological outcomes if not properly regulated.

    • Richard L. Gieseck III
    • , Mark S. Wilson
    •  & Thomas A. Wynn

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