Early life immunology

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Latest Reviews

  • Review |

    γδ T cells are found mainly in epithelial tissues, where they have crucial roles in tissue homeostasis and repair. Here, the authors describe how γδ T cells are activated and regulated in epithelial tissues, such as the skin and intestine, to mediate host microbial tolerance and provide protection against infection.

    • Morten M. Nielsen
    • , Deborah A. Witherden
    •  & Wendy L. Havran
  • Review |

    This Review focuses on how the complement cascade can both promote and inhibit antitumour immune responses. The authors discuss the potential of targeting complement components for immunotherapeutic purposes in patients with cancer.

    • Edimara S. Reis
    • , Dimitrios C. Mastellos
    • , Daniel Ricklin
    • , Alberto Mantovani
    •  & John D. Lambris
  • Review |

    Tissue-resident eosinophils selectively secrete cytokines and other mediators that have diverse functions in health and disease.

    • Peter F. Weller
    •  & Lisa A. Spencer
  • Review |

    Here, the authors discuss the role of cellular barriers in establishing immune privilege, both in the intestine and in other organs, such as the brain and the eyes. They compare protective epithelial and vascular barriers in different organs and examine how several pathologies are linked to the disruption of these barriers.

    • Ilaria Spadoni
    • , Giulia Fornasa
    •  & Maria Rescigno
  • Review |

    In this Review, the authors describe how type 2 immune responses drive tissue repair and fibrosis. They explain how these responses are crucial for repairing damaged tissue but can also lead to pathological outcomes if not properly regulated.

    • Richard L. Gieseck III
    • , Mark S. Wilson
    •  & Thomas A. Wynn
  • Opinion |

    Carl Figdor and colleagues propose that delivering cancer immunotherapy in the context of engineered three-dimensional scaffolds may boost anticancer immunity. The synthetic scaffolds, which can be linked to immunomodulatory factors, can act as immune niches to support the priming and maintenance of antitumour immune responses.

    • Jorieke Weiden
    • , Jurjen Tel
    •  & Carl G. Figdor

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