Featured
-
-
Original Article |
Development of potent class II transactivator gene delivery systems capable of inducing de novo MHC II expression in human cells, in vitro and ex vivo
- M L Palma
- , P Duangkhae
- & E T A Marques
-
Review |
Genetic pharmacology: progresses in siRNA delivery and therapeutic applications
- D Scherman
- , A Rousseau
- & V Escriou
-
Original Article |
Exposure to hypomethylating agent, 5-azacytidine, may improve iCasp9 suicide gene therapy for treating GvHD in allografts
- E Bôle-Richard
- , C Gamonet
- & M Deschamps
-
Original Article |
Hair cell stereociliary bundle regeneration by espin gene transduction after aminoglycoside damage and hair cell induction by Notch inhibition
- A Taura
- , K Taura
- & A F Ryan
-
Original Article - Enabling Technologies
| Open AccessA new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent
- H Cao
- , W Yu
- & B A Amendt
-
Original Article |
Intravesical treatment of advanced urothelial bladder cancers with oncolytic HSV-1 co-regulated by differentially expressed microRNAs
- K-X Zhang
- , Y Matsui
- & W W Jia
-
Original Article |
Adeno-associated virus-2-mediated TGF-β1 microRNA transfection inhibits adhesion formation after digital flexor tendon injury
- Y F Wu
- , W F Mao
- & J B Tang
-
Original Article |
In vitro gene manipulation of spinal muscular atrophy fibroblast cell line using gene-targeting fragment for restoration of SMN protein expression
- A Rashnonejad
- , C Gündüz
- & F Özkınay
-
Original Article |
Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR−/− mice
- G Li
- , C Chen
- & S Li
-
Short Communication
| Open AccessCRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting
- D G Courtney
- , J E Moore
- & C B T Moore
-
Short Communication |
Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus
- A P Dane
- , S C Cunningham
- & I E Alexander
-
Short Communication |
Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter
- C Zheng
- , B J Baum
- & I Alevizos
-
Original Article |
Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice
- R Li
- , E Buras
- & L Chan
-
Short Communication |
miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells
- P Kumar
- , S Bhattacharyya
- & R Biswas
-
Original Article |
Viral vector-based improvement of optic nerve regeneration: characterization of individual axons’ growth patterns and synaptogenesis in a visual target
- B J Yungher
- , X Luo
- & K K Park
-
Original Article |
Site promiscuity of coliphage HK022 integrase as a tool for gene therapy
- M Kolot
- , N Malchin
- & E Yagil
-
Original Article |
Localizing the RPGR protein along the cilium: a new method to determine efficacies to treat RPGR mutations
- R Da Costa
- , E Glaus
- & J Neidhardt
-
-
Original Article |
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin
- T Nakama
- , S Yoshida
- & T Ishibashi
-
Short Communication |
APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle
- A Kostrzak
- , M Henry
- & J-P Vartanian
-
Original Article |
Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model
- A Okal
- , K J Matissek
- & C S Lim
-
Short Communication |
Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells
- J Rivière
- , J Hauer
- & M Cavazzana
-
Short Communication |
Long-term in vivo imaging of translated RNAs for gene therapy
- K Pinel
- , J Lacoste
- & F Couillaud
-
Original Article |
MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain
- L Zeng
- , X He
- & G-Y Yang
-
Original Article |
Inhibition of hepatic fibrosis with artificial microRNA using ultrasound and cationic liposome-bearing microbubbles
- D Yang
- , Y-H Gao
- & G Wang
-
Short Communication |
De-targeting by miR-143 decreases unwanted transgene expression in non-tumorigenic cells
- F Kopp
- , M Schnoedt
- & M Ogris
-
Original Article |
MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma
- J A Ronald
- , R Katzenberg
- & S S Gambhir
-
Original Article |
Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways
- M P Cataldi
- & D M McCarty
-
Original Article |
Mutation-independent rescue of a novel mouse model of Retinitis Pigmentosa
- D L Greenwald
- , S M Cashman
- & R Kumar-Singh
-
Original Article |
Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs
- B L Ellis
- , M L Hirsch
- & M H Porteus
-
-
Original Article |
A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver
- S Fukunaga
- , G Kanda
- & H Kamiya
-
-
-
-
Original Article |
Investigation of the peak action wavelength of light-activated gene transduction
- M Myakishev-Rempel
- , J Kuper
- & E M Schwarz
-
Original Article |
Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy
- L Zang
- , M Nishikawa
- & Y Takakura
-
Enabling Technologies |
The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor
- Z Jin
- , S Maiti
- & L J N Cooper
-
Original Article |
A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells
- M C Golding
- & M R W Mann
-
-
Original Article |
Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver
- C Qiao
- , Z Yuan
- & X Xiao
-
Original Article |
microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors
- A Geisler
- , A Jungmann
- & O J Müller
-
Enabling Technologies
| Open AccessTransfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells
- N Zhao
- , J M Fogg
- & Y Zu
-
Original Article |
Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair
- M L Hirsch
- , L Green
- & R J Samulski
Browse broader subjects
Browse narrower subjects
- Cell division
- Chromatin
- Chromosomes
- CRISPR-Cas systems
- DNA damage and repair
- DNA metabolism
- DNA recombination
- DNA replication
- Epigenetics
- Non-coding RNAs
- Nuclear organization
- Post-translational modifications
- Protein folding
- Proteolysis
- Proteomics
- Riboswitches
- Ribozymes
- RNA metabolism
- RNAi
- Single-molecule biophysics
- Transcription
- Transcriptomics
- Translation
- Transposition