Molecular biology

Definition

Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.

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Latest Research and Reviews

  • Reviews |

    Accumulation of misfolded protein in neurons is a common feature of many neurodegenerative diseases. In this Review, Hetz and Saxena discuss the latest advances in our understanding about the mechanisms by which protein misfolding causes neurodegeneration, and look at novel insights into the role of cellular responses to protein misfolding in synaptic function and in inflammatory and mechanical injury in the nervous system.

    • Claudio Hetz
    •  & Smita Saxena
  • Research |

    Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting.

    • Azusa Inoue
    • , Lan Jiang
    • , Falong Lu
    • , Tsukasa Suzuki
    •  & Yi Zhang
  • Research |

    The large number of small, similarly sized proteins and the small number of heavy RNA molecules that make up a ribosome reduce the time required for reproduction.

    • Shlomi Reuveni
    • , Måns Ehrenberg
    •  & Johan Paulsson
    Nature 547, 293–297
  • Research |

    Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

    • Chen-Song Zhang
    • , Simon A. Hawley
    • , Yue Zong
    • , Mengqi Li
    • , Zhichao Wang
    • , Alexander Gray
    • , Teng Ma
    • , Jiwen Cui
    • , Jin-Wei Feng
    • , Mingjiang Zhu
    • , Yu-Qing Wu
    • , Terytty Yang Li
    • , Zhiyun Ye
    • , Shu-Yong Lin
    • , Huiyong Yin
    • , Hai-Long Piao
    • , D. Grahame Hardie
    •  & Sheng-Cai Lin
  • Research | | open

    Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.

    • Alessandra Ferrari
    • , Raffaella Longo
    • , Erika Fiorino
    • , Rui Silva
    • , Nico Mitro
    • , Gaia Cermenati
    • , Federica Gilardi
    • , Béatrice Desvergne
    • , Annapaola Andolfo
    • , Cinzia Magagnotti
    • , Donatella Caruso
    • , Emma De Fabiani
    • , Scott W. Hiebert
    •  & Maurizio Crestani

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