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| Open AccessMacrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis
- Qiong Wu
- , Zongwen Liang
- & Yingying Cao
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| Open AccessPolyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- Dandan Han
- , Yujun Wu
- & Junjun Wang
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| Open AccessInflammasome activation occurs in CD4+ and CD8+ T cells during graft-versus-host disease
- Sarah Talley
- , David J. Rademacher
- & Edward M. Campbell
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Article
| Open AccessDepletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte
- Zhiqin Fang
- , Yutong Wang
- & Mingzhu Yin
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| Open AccessInterfering with Rac1-activation during neonatal monocyte-macrophage differentiation influences the inflammatory responses of M1 macrophages
- Hang Fu
- , Ping Zhang
- & Xiao-Yun Zhong
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| Open AccessThe arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Esraa Shosha
- , Rami A. Shahror
- & Abdelrahman Y. Fouda
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| Open AccessLncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation
- Sisi Chen
- , Jiali Wang
- & Hong Nian
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| Open AccessCXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation
- Wei Zhuang
- , Jinfeng Zhou
- & Changsheng Du
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| Open AccessTRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs
- Monika Vashisht
- , Huaibin Ge
- & Jing H. Wang
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| Open AccessGasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis
- Ni Lian
- , Yujie Chen
- & Xu Chen
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| Open AccessLysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
- Jiacheng Wu
- , Ye Hu
- & Xiaoqing Xu
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| Open AccessCircMIB2 therapy can effectively treat pathogenic infection by encoding a novel protein
- Weiwei Zheng
- , Linchao Wang
- & Tianjun Xu
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| Open AccessFicolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway
- Xu Wu
- , Yixia Jiang
- & Xiaowu Tan
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| Open AccessA HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway
- Xiaohan Wu
- , Lingyan Xu
- & Yanhong Gu
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Comment
| Open AccessCancer stem cell immunoediting by IFNγ
The secretion of interferon gamma (IFNG, best known as IFNγ) by immune effector cells generally mediates potent anticancer effects. Recent data from Beziaud et al. demonstrate that—at least in some circumstances—IFNγ can edit the breast cancer microenvironment to promote stemness, disease progression and resistance to (immuno)therapy.
- Claudia Galassi
- & Lorenzo Galluzzi
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Article
| Open AccessOTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
- Lien Verboom
- , Christopher J. Anderson
- & Geert van Loo
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Article
| Open AccessThe ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
- Alessandra Romagnoli
- , Martina Di Rienzo
- & Gian Maria Fimia
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| Open AccessscRNA-seq revealed the special TCR β & α V(D)J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells
- Lanwei Zhu
- , Qi Peng
- & Xinsheng Yao
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| Open AccessThe deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2
- Kunjan Harit
- , Rituparna Bhattacharjee
- & Gopala Nishanth
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Review Article
| Open AccessPyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance
- Ya Liu
- , Haibo Lei
- & Yixiang Hu
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Article
| Open AccessNew insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy
- Taylor P. Uccello
- , Maggie L. Lesch
- & Scott A. Gerber
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Perspective
| Open AccessBalancing the functions of DNA extracellular traps in intracellular parasite infections: implications for host defense, disease pathology and therapy
- Carolina Cattoni Koh
- , Kenneth J. Gollob
- & Walderez O. Dutra
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Article
| Open AccessNEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells
- Sara Petillo
- , Elena Sproviero
- & Marco Cippitelli
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Article
| Open AccessPTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation
- Juan Du
- , Yahui Liu
- & Xiao Su
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Article
| Open AccessEfferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling
- Emily R. Quarato
- , Noah A. Salama
- & Laura M. Calvi
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Article
| Open AccessB cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury
- Zhun Sun
- , Anning Chen
- & Guojun Qian
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Article
| Open AccessMacrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway
- Bin Yang
- , Yunjie Zhao
- & Guang Liang
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Review Article
| Open AccessEffects of altered glycolysis levels on CD8+ T cell activation and function
- Jiaying Cao
- , Shan Liao
- & Yanhong Zhou
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Article
| Open AccessE3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR
- Jiaying Huang
- , Zhou Yu
- & Xuetao Cao
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Review Article
| Open AccessSARS-CoV-2 infection and COVID-19 vaccination in cancer patients undergoing immune checkpoint inhibitors
- Yang Yang
- & Gaosi Xu
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Article
| Open AccessRNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
- Pei-Yao Liu
- , Chih-Yuan Chen
- & Ying-Chuan Chen
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Article
| Open AccessTargeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
- Shiao-Ya Hong
- , Ya-Ting Lu
- & Kun-Lun Huang
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Article
| Open AccessTIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3
- Manish Mishra
- , Manisha Yadav
- & Pradip Sen
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Article
| Open AccessTLR7-MyD88-DC-CXCL16 axis results neutrophil activation to elicit inflammatory response in pustular psoriasis
- Jiajing Lu
- , Xiaoyuan Zhong
- & Yuling Shi
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Article
| Open AccessSox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia
- Dongyue Zhang
- , Xiaoxi Cui
- & Guoguang Zheng
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Article
| Open AccessRadiation therapy improves CAR T cell activity in acute lymphoblastic leukemia
- Mayumi Sugita
- , Takahiro Yamazaki
- & Monica L. Guzman
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Article
| Open AccessNovel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients
- Shijie Qin
- , Xiaohong Yao
- & Xiuwu Bian
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Article
| Open AccessGasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection
- Elien Eeckhout
- , Lisa Hamerlinck
- & Andy Wullaert
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Article
| Open AccessLncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1α/NF-κB axis in psoriasis
- Yibo Hu
- , Li Lei
- & Jing Chen
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Article
| Open AccessXIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death
- Axel Witt
- , Tatiana Goncharov
- & Domagoj Vucic
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Article
| Open AccessCMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3
- A-bin You
- , Hu Yang
- & Feng Ye
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Article
| Open AccessIL-33 promotes double negative T cell survival via the NF-κB pathway
- Xiaojing Sun
- , Chunpan Zhang
- & Li Li
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Article
| Open AccessInfluenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death
- Chang-Ung Kim
- , Dahwan Lim
- & Doo-Jin Kim
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Article
| Open AccessRIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy
- Zijing Huang
- , Jiajian Liang
- & Dingguo Huang
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Article
| Open AccessTREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment
- Wenchuan Zhou
- , Yutong Zhou
- & Jing Li
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Article
| Open AccessDeletion of Gpatch2 does not alter Tnf expression in mice
- Destiny Dalseno
- , Holly Anderton
- & Philippe Bouillet
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Article
| Open AccessMutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation
- Daria Chirita
- , Pauline Bronnec
- & Thomas Henry
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Article
| Open AccessType I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients
- Peter Holicek
- , Iva Truxova
- & Jitka Fucikova
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Article
| Open AccessGPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway
- Guoqiang Fan
- , Yanfei Li
- & Xiaojing Yang
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