Featured
-
-
Article
| Open AccessMitochondrial E3 ligase MARCH5 is a safeguard against DNA-PKcs-mediated immune signaling in mitochondria-damaged cells
- June Heo
- , Yeon-Ji Park
- & Hyeseong Cho
-
Article
| Open AccessCaspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide
- Marta Cristaldi
- , Marco Buscetta
- & Chiara Cipollina
-
Article
| Open AccessLysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
- Jiacheng Wu
- , Ye Hu
- & Xiaoqing Xu
-
Article
| Open AccessA HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway
- Xiaohan Wu
- , Lingyan Xu
- & Yanhong Gu
-
Article
| Open AccessThe ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
- Alessandra Romagnoli
- , Martina Di Rienzo
- & Gian Maria Fimia
-
Article
| Open AccessE3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR
- Jiaying Huang
- , Zhou Yu
- & Xuetao Cao
-
Article
| Open AccessLncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1α/NF-κB axis in psoriasis
- Yibo Hu
- , Li Lei
- & Jing Chen
-
Article
| Open AccessMLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
- Cheng Peng
- , Guangping Tu
- & Xiao Yu
-
Article
| Open AccessA lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury
- Xintong Zheng
- , Mingwei Wang
- & Mengqing Xiang
-
Article
| Open AccessLysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion
- Laura Migliari Branco
- , Marcelo Pires Amaral
- & Karina Ramalho Bortoluci
-
Article
| Open AccessEGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis
- Xuedi Zhang
- , Cuiping Chen
- & Jing Tang
-
Article
| Open AccessApoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies
- Di Wu
- , Zhaowei Wang
- & Xi Zhou
-
Article
| Open AccessPKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis
- Wenjie Zuo
- , Mai Wakimoto
- & Takashi Fujita
-
Article
| Open AccessEssential role of Rnd1 in innate immunity during viral and bacterial infections
- Akhilesh Kumar
- , Shalabh Mishra
- & Himanshu Kumar
-
Article
| Open AccessNeurotropic EV71 causes encephalitis by engaging intracellular TLR9 to elicit neurotoxic IL12-p40-iNOS signaling
- Rai-Hua Lai
- , Yen-Hung Chow
- & Jyh-Lyh Juang
-
Article
| Open AccessBlocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models
- Hao Wang
- , Damon J. Tumes
- & Steven Bozinovski
-
Article
| Open AccessDanger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages
- Supriya Murthy
- , Isabel Karkossa
- & Manuela Rossol
-
Article
| Open AccessInduced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting
- Jie Jin
- , Xianbin Meng
- & Haiteng Deng
-
Article
| Open AccessSensing soluble uric acid by Naip1-Nlrp3 platform
- Tarcio Teodoro Braga
- , Mariana Rodrigues Davanso
- & Niels Olsen Saraiva Camara
-
Article
| Open AccessHepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
- Qian Li
- , Jun Wang
- & Mengji Lu
-
Article
| Open AccessMDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response
- Miguel Rodríguez Pulido
- , Encarnación Martínez-Salas
- & Margarita Sáiz
-
Perspective
| Open AccessIs hydroxychloroquine beneficial for COVID-19 patients?
- Xing Li
- , Ying Wang
- & Erwei Sun
-
Article
| Open AccessAnnexin-A1 promotes RIG-I-dependent signaling and apoptosis via regulation of the IRF3–IFNAR–STAT1–IFIT1 pathway in A549 lung epithelial cells
- Gracemary L. R. Yap
- , Karishma Sachaphibulkij
- & Lina H. K. Lim
-
Article
| Open AccessIntracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion
- Tongtian Zhuang
- , Xiuli Yi
- & Chunying Li
-
Article
| Open AccessNeutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling
- Xinhao Zhao
- , Le Yang
- & Liying Li
-
Article
| Open AccessTLR5: A prognostic and monitoring indicator for triple-negative breast cancer
- Dai Shi
- , Shanshan Zhao
- & Guihua Hou
-
Article
| Open AccessG3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response
- Wenping Yang
- , Yi Ru
- & Haixue Zheng
-
Article
| Open AccessInhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock
- Chenxi Li
- , Haiyan Gu
- & Zhuoya Li
-
Article
| Open AccessTLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis
- Fang-Yuan Liu
- , Di Fan
- & Qi-Zhu Tang
-
Article
| Open AccessGasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis
- Chenxuan Yang
- , Ping Sun
- & Melanie J Scott
-
Article
| Open AccessRNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux
- Leandro Silva da Costa
- , Ahmed Outlioua
- & Damien Arnoult
-
Article
| Open AccessTryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection
- Tanmay Majumdar
- , Shagun Sharma
- & Shibnath Mazumder
-
Original Article
| Open AccessDouble-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway
- Changwei Li
- , Kaizhe Chen
- & Lianfu Deng
-
Original Article
| Open AccessEssential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways
- Puja Kumari
- , Irene Saha
- & Himanshu Kumar
-
Original Article
| Open AccessARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65
- Jun Meng
- , Zhenyu Yao
- & Jinquan Cheng
-
News and Commentary
| Open AccessThe lure of the lipids: how defensins exploit membrane phospholipids to induce cytolysis in target cells
- Amy A Baxter
- , Ivan KH Poon
- & Mark D Hulett
-
Original Article
| Open AccessA link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA
- Yi-Ting Wang
- , Hou-Hsien Chiang
- & Wei-Shiung Yang
-
Original Article
| Open AccessTLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles)
- Y Xing
- , R Cao
- & H-M Hu
-
Original Article
| Open AccessPML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model
- Vuk Palibrk
- , Rajikala Suganthan
- & Stig Ove Bøe
-
Original Article
| Open AccessGranzyme M has a critical role in providing innate immune protection in ulcerative colitis
- F Souza-Fonseca-Guimaraes
- , Y Krasnova
- & M J Smyth
-
Original Article
| Open AccessToll-like receptor 4 modulates the cochlear immune response to acoustic injury
- R R Vethanayagam
- , W Yang
- & B H Hu
-
Review
| Open AccessThe emerging role of Toll-like receptor 4 in myocardial inflammation
- Y Yang
- , J Lv
- & W Yi
-
Original Article
| Open AccessPER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice
- T Wang
- , Z Wang
- & J Zhang
-
Original Article
| Open AccessAlkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system
- K Wang
- , R Xu
- & C Mao
-
Original Article
| Open AccessIRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs
- L Guo
- , C-H Chen
- & J-C Li
-
Original Article
| Open AccessThe NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine
- L Baron
- , A Gombault
- & I Couillin
-
Original Article
| Open AccessNK cell intrinsic regulation of MIP-1α by granzyme M
- N Baschuk
- , N Wang
- & D M Andrews
-
Original Article
| Open AccessTLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain
- A Pla
- , M Pascual
- & C Guerri
-
Original Article
| Open AccessFunctional RIG-I-like receptors control the survival of mesenchymal stem cells
- K Yang
- , J Wang
- & X Huang