Nature Reviews Gastroenterology & Hepatology

Robotic surgery, inspired by the Perspective on p171

Artificial intelligence and automation in endoscopy and surgery

François Chadebecq
Laurence B. Lovat
Danail Stoyanov

Perspective 09 November 2022

Featured

The microbiota and the gut–liver axis in primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD) and potentially provides unique insights into the gut–liver axis. This Review explores these links and provides an overview of the gut microbiome in PSC, including PSC–IBD, exploring related hypotheses of disease mechanisms.

Johannes R. Hov
Tom H. Karlsen
Review Article 09 Nov 2022
Current developments in gastric cancer: from molecular profiling to treatment strategy

Gastric and gastro-oesophageal cancer is a leading cause of cancer-related death worldwide with a poor prognosis. This Review provides a comprehensive overview of current treatment strategies set on a molecular basis, and discusses future therapeutic avenues.

Maria Alsina
Virginia Arrazubi
Josep Tabernero
Review Article 07 Nov 2022
Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution

Intestinal gluconeogenesis (IGN) is a conserved mechanism documented in all vertebrates and it has a crucial role in energy homeostasis and metabolic processes. This Perspective provides an overview of IGN and discusses its importance in natural selection.

Amandine Gautier-Stein
Gilles Mithieux
Perspective 05 Dec 2022

Current issue

Risk minimization of JAK inhibitors in ulcerative colitis following regulatory guidance

Silvio Danese
Virginia Solitano
Laurent Peyrin-Biroulet
Comment 19 Dec 2022
Lactylation and HCC progression

Eleni Kotsiliti
Research Highlight 07 Feb 2023
Effect of bariatric surgery on risk of oesophagogastric cancer

Jordan Hindson
In Brief 08 Feb 2023
The microbiota and the gut–liver axis in primary sclerosing cholangitis

Johannes R. Hov
Tom H. Karlsen
Review Article 09 Nov 2022
Current developments in gastric cancer: from molecular profiling to treatment strategy

Maria Alsina
Virginia Arrazubi
Josep Tabernero
Review Article 07 Nov 2022
Artificial intelligence and automation in endoscopy and surgery

François Chadebecq
Laurence B. Lovat
Danail Stoyanov
Perspective 09 Nov 2022

Contents

View all issues

Announcements

2022 - Year in Review

Leading experts describe their key advances of the year. Topics covered include: IBD; IBS; pancreatic cancer; gut-brain axis; gut microbiota; NAFLD and obesity; ALD
COVID-19

FREE ACCESS - This Collection covers the COVID-19 pandemic and its implications for patients with gastrointestinal and liver diseases.
Follow us on Twitter!

Follow us for news about the journal and the latest updates from the gastroenterology and hepatology field.

Latest Reviews & Analysis

- Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
  
  In this Review, Llovet and colleagues discuss advances in our knowledge of the pathogenesis and clinical management of nonalcoholic steatohepatitis-related hepatocellular carcinoma. They also discuss future prospects and unmet needs.
  
  Josep M. Llovet
  Catherine E. Willoughby
  Scott L. Friedman
  
  Review Article 17 Mar 2023
- Human intestinal B cells in inflammatory diseases
  
  Intestinal B cell responses are crucial in maintaining gut homeostasis. This Review discusses the role of human intestinal B cells in health and intestinal disease and provides a comprehensive overview of their features.
  Jo Spencer
  Mats Bemark
  
  Review Article 27 Feb 2023
- The gasdermin protein family: emerging roles in gastrointestinal health and disease
  
  Gasdermins (GSDMs) are proteins primarily involved in pyroptosis, among other cellular functions. This Review provides a comprehension summary of GSDM biology, focusing on the gastrointestinal tract and addressing clinical implications and future research.
  Giuseppe Privitera
  Nitish Rana
  Theresa T. Pizarro
  
  Review Article 13 Feb 2023
- Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
  
  Preclinical research is required to improve our understanding of cholangiocarcinoma (CCA). In this Consensus Statement, a task force of experts provides recommendations on the criteria for preclinical models of CCA to increase disease understanding and help to develop novel therapeutic approaches.
  Diego F. Calvisi
  Luke Boulter
  Yoshimasa Saito
  
  Consensus Statement 08 Feb 2023
- Immunology and immunotherapy of cholangiocarcinoma
  
  Cholangiocarcinoma is the second most common primary liver cancer, and its incidence is rising worldwide. This Review discusses the immunology of cholangiocarcinoma and provides a comprehensive overview of the preclinical and clinical immunotherapy studies.
  Tim F. Greten
  Robert Schwabe
  Xin W. Wang
  
  Review Article 25 Jan 2023
- Therapeutic landscape and future direction of metastatic colorectal cancer
  Hideaki Bando
  Atsushi Ohtsu
  Takayuki Yoshino
  
  Review Article 20 Jan 2023
- Gene therapy for liver diseases — progress and challenges
  Nerea Zabaleta
  Carmen Unzu
  Gloria Gonzalez-Aseguinolaza
  
  Review Article 16 Jan 2023
- Improving IBD outcomes in the era of many treatment options
  Taku Kobayashi
  Toshifumi Hibi
  
  Year in Review 12 Jan 2023
- Updated epidemiology of gastrointestinal cancers in East Asia
  Junjie Huang
  Don Eliseo Lucero-Prisno III
  Martin C. S. Wong
  
  Review Article 11 Jan 2023

News & Comment

Microbiota-derived metabolites in PDAC

Eleni Kotsiliti
Research Highlight 13 Mar 2023
New target and timing in PDAC immunotherapy?

Ian Fyfe
In Brief 07 Mar 2023
Safer pioglitazone alternative is effective

Ian Fyfe
In Brief 07 Mar 2023
Two therapeutic antibodies better than one

Ian Fyfe
In Brief 07 Mar 2023
Insight into virome development

Ian Fyfe
In Brief 07 Mar 2023
Mucus secretion from colonic goblet cells is regulated by autophagy and ER stress

Jordan Hindson
Research Highlight 01 Mar 2023

In this article series, Nature Reviews Gastroenterology & Hepatology examines the cutting-edge techniques and technologies currently applied in gastrointestinal and liver research and clinical practice, and the approaches that might be available to investigators, clinicians and surgeons in the future.

Series 07 Jan 2022

Trending - Altmetric

Events

EMBL Course: Advanced electron microscopy for cell biology

20 June 2023 – 30 June 2023
EMBL Advanced Training Centre
B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers

06 June 2023 – 10 June 2023
Keystone Resort
EMBL Conference: Terra incognita: navigating ethical boundaries in the life sciences

19 June 2023 – 20 June 2023
EMBL Advanced Training Centre
EMBO | EMBL Symposium: The human microbiome

20 September 2023 – 23 September 2023
EMBL Advanced Training Centre
EMBL Course: Liquid biopsies

09 October 2023 – 14 October 2023
EMBL Advanced Training Centre

Jobs

Polymer Scientist (m/f/div) for Materials Central Scientific Facility

Max Planck Institute for Intelligent Systems (MPIIS)
Stuttgart, Germany
Scientific Coordinator (m/f/div)

Max Planck Institute for Biology of Ageing (MPIAGE)
Köln, Germany
Research Technician- Morrison Lab

Howard Hughes Medical Institute (HHMI)
Dallas, United States
BRF Research Officers (Animal Technician)/Support Technicians (Bank Staff)

Francis Crick Institute
London, United Kingdom
Postdoctoral Training Fellow - Applied Biotechnology Laboratory - Rodriques Lab

Francis Crick Institute
London, United Kingdom

Featured

Announcements

Advertisement

Trending - Altmetric

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods

Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

Search

Quick links