adipocytes

From gene variants to disease mechanisms

  • Viktoria Glunk
  • Samantha Laber
  • Melina Claussnitzer
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    This Focus brings together a selection of Reviews, Perspectives and related research that integrate the most recent advances in our understanding of how the brain controls energy homeostasis. This is presented both from a neurocircuit perspective describing the initiation or cessation of eating, as well as from a more detailed view of how these processes occur at the cellular level.

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    • Functional genomic analyses reveal a complex relationship between the COBLL1 gene and metabolic health, as well as how the same variant can both reduce body fat and increase the risk of type 2 diabetes.

      • Hannah Maude
      • Inês Cebola
      News & Views
    • How mammals enter hypometabolic states, known as torpor and hibernation, has fascinated researchers for decades, but the central control mechanisms that regulate entry into torpor have surfaced only recently. Yang and colleagues demonstrate that torpor-like hypometabolic states can be induced non-invasively by ultrasound, providing new routes for exploiting the underlying mechanisms and biomedical applications of this process in the future.

      • Martin Jastroch
      • Frank van Breukelen
      News & Views
    • M6A RNA modifications mediate RNA processing and stability. Ceramides are lipid metabolites containing an amino acid-based backbone, which promote metabolic dysfunction. Wang et al. describe a novel m6A-dependent regulatory node that tunes ceramide-generating enzymes.

      • Mariah Weber-Stout
      • Scott A. Summers
      • William L. Holland
      News & Views
    • Glycolysis provides building blocks for the proinflammatory activation of macrophages and simultaneously generates pyruvate. In this issue of Nature Metabolism, Ran et al. provide evidence that the transport of pyruvate to fuel the Krebs cycle in the mitochondria is not required in the inflammatory response.

      • Laurent Yvan-Charvet
      • Edward Benjamin Thorp
      News & Views
    • Most of human microbiome research has focused on analysing faecal samples, which represent the final stop of the digestive journey. Two recent articles use a novel sampling approach to capture luminal content at different points during digestion and reveal that the analysis of faecal samples tells only a fraction of the story.

      • Robert A. Quinn
      • Christian Martin
      • Douglas V. Guzior
      News & Views