Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rinella, M. E. et al. J. Hepatol. 79, 1542–1556 (2023).
Kanwal, F., Neuschwander-Tetri, B. A., Loomba, R. & Rinella, M. E. Hepatology https://doi.org/10.1097/HEP.0000000000000670 (2023).
Ratziu, V. & Boursier, J. J. Hepatol. 80, e51–e52 (2023).
Song, S. J., Che-To Lai, J., Lai-Hung Wong, G., Wai-Sun Wong, V. & Cheuk-Fung Yip, T. J. Hepatol. 80, e54–e56 (2023).
Hagstrom, H., Vessby, J., Ekstedt, M. & Shang, Y. J. Hepatol. 80, e76–e77 (2023).
Li, M. & Xie, W. J. Hepatol. 80, e53–e54 (2023).
Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R. & Arrese, M. Nat. Rev. Gastroenterol. Hepatol. 20, 764–783 (2023).
Gallage, S. et al. Nat. Metab. 4, 1632–1649 (2022).
Hsu, C. L. & Schnabl, B. Nat. Rev. Microbiol. 21, 719–733 (2023).
Demir, M. et al. J. Hepatol. 76, 788–799 (2022).
Hsu, C. L. et al. Dig. Dis. Sci. 68, 3059–3069 (2023).
Azuma, H. et al. Nat. Biotechnol. 25, 903–910 (2007).
Song, Y. et al. Science 371, 1019–1025 (2021).
Kaffe, E. et al. Cell 186, 3793–3809.e26 (2023).
Acknowledgements
C.L.H. receives funding support from NIAAA (K99AA031328), American Association for the Study of Liver Diseases Foundation (CTORA23-208366), and the Southern California Research Center for ALPD and Cirrhosis funded by NIH P50AA011999. R.L. receives funding support from NIEHS (5P42ES010337), NCATS (5UL1TR001442), NIDDK (U01DK130190, U01DK061734, R01DK106419, P30DK120515, R01DK121378, R01DK124318), NHLBI (P01HL147835).
Author information
Authors and Affiliations
Contributions
C.L.H. drafted the manuscript and R.L. carried out a critical revision of the manuscript.
Corresponding author
Ethics declarations
Competing interests
C.L.H. declares no competing interests. R.L. serves as a consultant to Aardvark Therapeutics, Altimmune, Anylam/Regeneron, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, Bristol-Myer Squibb, CohBar, Eli Lilly, Galmed, Gilead, Glympse bio, Hightide, Inipharma, Intercept, Inventiva, Ionis, Janssen Inc., Madrigal, Metacrine, Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Merck, Pfizer, Sagimet, Theratechnologies, 89 bio, Terns Pharmaceuticals and Viking Therapeutics. In addition, his institutions received research grants from Arrowhead Pharmaceuticals, Astrazeneca, Boehringer-Ingelheim, Bristol-Myers Squibb, Eli Lilly, Galectin Therapeutics, Galmed Pharmaceuticals, Gilead, Intercept, Hanmi, Intercept, Inventiva, Ionis, Janssen, Madrigal Pharmaceuticals, Merck, NGM Biopharmaceuticals, Novo Nordisk, Merck, Pfizer, Sonic Incytes and Terns Pharmaceuticals. Co-founder of LipoNexus Inc.
Peer review
Peer review information
Nature Metabolism thanks Herbert Tilg for their contribution to the peer review of this work.
Supplementary information
Supplementary Table
CVD, cardiovascular dysfunction; HLD, hyperlipidaemia; HTN, hypertension; IR, insulin resistance.
Rights and permissions
About this article
Cite this article
Hsu, C.L., Loomba, R. From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research. Nat Metab 6, 600–602 (2024). https://doi.org/10.1038/s42255-024-00985-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-024-00985-1