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  • Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.

    • Cynthia L. Hsu
    • Rohit Loomba
    Comment
  • The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses consuming excess energy. We argue that this chronic state of hypermetabolism imposes energetic constraints, thus causing mitochondrial disease pathophysiology, calling for careful translational studies from organelle to organism.

    • Alexander J. Sercel
    • Gabriel Sturm
    • Martin Picard
    Comment
  • The field of personalized nutrition hypothesizes that ‘big data’ — biological, behavioural, social and environmental — can be leveraged to make more precise and effective dietary recommendations to individuals for improving health outcomes, compared to generic dietary advice. This article describes the research questions that need to be answered to understand whether personalized nutrition brings additional clinical utility.

    • Nicola Guess
    Comment
  • This month, Nature Metabolism turns five. For a young journal such as ours, this anniversary represents a milestone worth celebrating, and a welcome opportunity to look back.

    Editorial
  • Here we reflect on touching points between basic science and clinical research, while highlighting key points to consider when submitting clinical work to our journal.

    Editorial
  • Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.

    • Gary Siuzdak
    Comment
  • Spatial metabolomics has matured and is driving innovation in mass spectrometry, metabolomics and spatial omics. With exciting discoveries, complementary capabilities and increasing accessibility, it has secured its place in the spatial biology toolbox, showing promise in biology, medicine and pharmacology.

    • Theodore Alexandrov
    Comment
  • Metabolic networks in microbial organisms are highly diverse. Unravelling this metabolic flexibility not only reveals fundamental metabolic insights but also can yield benefits for society at large

    Editorial
  • Reproducibility and replication are cornerstones of scientific research and depend on detailed reporting of experimental conditions. Here, we discuss key points and editorial policies that authors need to be aware of when submitting an article to Nature Metabolism.

    Editorial
  • Growing evidence demonstrates the metabolic benefits of repeated cold exposure in humans. Here, we argue that skeletal muscle thermogenesis, rather than the stimulation of thermogenic adipose tissue, is required to elicit these benefits in humans.

    • Logan K. Townsend
    • Dongdong Wang
    • Denis P. Blondin
    Comment
  • Lab websites are an important resource for making yourself known to the research community. Here we explain why having an informative, up-to-date website can be a great tool for keeping the research community informed about your current projects.

    Editorial
  • The metabolomics literature suffers from ambiguity in the nomenclature for individual metabolites, which introduces a disconnect between publications and leads to misinterpretations. This Comment proposes recommendations for metabolite annotations to engage the scientific community and publishers to adopt a more consistent approach to metabolite nomenclature.

    • Ville Koistinen
    • Olli Kärkkäinen
    • Kati Hanhineva
    Comment
  • Scientific meetings are the perfect venue for staying on top of the field and building new relationships with researchers from all career stages, as well as solidifying bonds with current authors. Here we explain why editors of Nature Metabolism attend conferences and what we do when we get there.

    Editorial