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NCOR1/2 and glucocorticoid receptor orchestrate hepatic function

Nature Metabolism (2024)Cite this article

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In this issue of Nature Metabolism, the research team of Mitchell Lazar reveals unexpected consequences of double loss of the coregulators NCOR1 and NCOR2 (NCOR1/2) in hepatocytes of adult mice, which affects chromatin functioning and glucocorticoid receptor (GR)-mediated gene transcription.

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Fig. 1: Adult loss of NCOR1/2 in mouse hepatocytes compromises gluconeogenesis and leads to a rapidly failing liver.

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Acknowledgements

The authors receive research support from VIB (KadBo), the Research Foundation Flanders (FWO) (G0A5124N) and UGent BOF/24J/2021/374.

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Authors and Affiliations

  1. VIB-UGent Center for Medical Biotechnology, Ghent, Belgium

    Chloé Van Leene & Karolien De Bosscher

  2. Department of Biomolecular Medicine, Ghent University, Ghent, Belgium

    Chloé Van Leene & Karolien De Bosscher

Authors
  1. Chloé Van Leene
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  2. Karolien De Bosscher
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Correspondence to Karolien De Bosscher.

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Van Leene, C., De Bosscher, K. NCOR1/2 and glucocorticoid receptor orchestrate hepatic function. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01028-5

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