Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The inference process of medical-image classifiers can be audited by levering the expertise of physicians to identify medically meaningful features in ‘counterfactual’ images produced via generative AI.
Patient-derived intestinal organoids and tumouroids supplemented with immune cells can be used to predict and study the on-target off-tumour toxicities of T-cell-engaging bispecific antibodies and to capture inter-patient variabilities in the responses to the antibodies.
Closed-loop spinal cord stimulation with commercially available electrodes can evoke sensations in the missing foot of three individuals with transtibial amputation, providing them with improved balance and gait and reducing phantom limb pain.
The targeted integration of large DNA payloads into primary human T cells can be efficiently achieved non-virally by leveraging Cas9-based editing and the DNA-repair pathway homology-mediated end joining.
Nonlinear latent factors and latent structures in the activity of neural populations can be computationally modelled to enable flexible inference and to better predict neural activity and behaviour.
The growth of aortic aneurysms can be predicted via a dimensionless physiomarker, derived from first principles and calculated from data acquired via 4D flow magnetic resonance imaging, that describes a transition from stable blood flow to unstable aortic fluttering.
The composition of lipid nanoparticles for the delivery of tumour-antigen-encoding mRNA can be optimized via a screening method to enhance antitumour activity via the modulation of the immune activity of helper T cells.
Linear mathematical models derived from measurements of local field potentials and of whole-brain blood-oxygen-level-dependent neural activity predict resting-state neural dynamics at least as accurately as nonlinear models.
Antigen-restricted mature T cells can be generated from pluripotent stem cells edited to lack endogenous T cell receptors and class I major histocompatibility complexes by introducing the T cell selection components into the stromal microenvironment.
A wide-field fluorescence microscope leveraging a spinning disc and high-speed cameras enables the recording of neural activities and neutrophil trajectories at micrometric resolution on curved cortical surfaces in live mice.
Optimized base editors targeting the exon-7 mutation in SMN2 restore expression of the survival motor neuron (SMN) protein to normal levels, as shown in mice with spinal muscular atrophy and in fibroblasts from patients with this genetic disease.
A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.
The transplantation and long-term survival of hydrogel-encapsulated islets can be enhanced by first using a catheter to create a subcutaneous cavity and to trigger inflammation-induced local neovascularization.
A subcutaneous colon-specific niche consisting of colon epithelial cells, decellularized colon extracellular matrix and immunosuppressive nanofibres reduced inflammation in the gastrointestinal tract of mice with established ulcerative colitis.
Skin-microangiopathy phenotypes can be correlated with diabetes stage by leveraging clinically explainable morphophysiological features obtained from the analysis, via machine learning, of raster-scan optoacoustic mesoscopy images of skin on the leg.
Photoacoustic tomography using a single laser pulse and a single element functioning as thousands of virtual detectors allows for the volumetric capture of fast haemodynamic changes in the feet of human volunteers.
Barcoding individual cells with microparticles emitting near-infrared laser light enables the use of flow cytometry for the measurement of time-resolved single-cell dynamics with more markers and fewer colours.
Replacing the extracellular domains of heterodimeric cytokine receptors in chimeric antigen receptor T cells with two leucine zipper motifs leads to optimal JAK/STAT signalling and augments the effector function of the T cells.
Successive single-shot wide-field photoacoustic images can be used to estimate the speed and direction of blood flow at more than 5 mm deep from the skin’s surface.
Metabolic rewiring during tachycardia promotes tissue hypoxia, elevated glucose utilization and the suppression of oxidative phosphorylation, driving contractile dysfunction.