Welcome to the Nature Cell Biology and Nature Reviews Molecular Cell Biology joint Focus on Systems Biology: a User's Guide. This collection of Review-type articles are designed as highly accessible and practical guides to some of the most important approaches and challenges in systems biology. We acknowledge the financial support of Pfizer, The Mathworks, Merrimack, Novartis and Entelos. This Focus was produced in association with the US National Centers for Systems Biology and the journal Molecular Systems Biology.

Systems biology experts discuss the promise and the challenges of this emerging field in the accompanying Podcast, which was produced with support from Applied Precision.



Editorial

All systems go!

doi:10.1038/sysbiol-s3

November 2006

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Reviews

Linking publication, gene and protein data

Paul Kersey and Rolf Apweiler

doi:10.1038/ncb1495

Nature Cell Biology advance online publication, 22 October 2006

Modelling data across labs, genomes, space and time

Jason R. Swedlow, Suzanna E. Lewis and Ilya G. Goldberg

doi:10.1038/ncb1496

Nature Cell Biology advance online publication, 22 October 2006

Collecting and organizing systematic sets of protein data

John G. Albeck, Gavin MacBeath, Forest M. White, Peter K. Sorger, Douglas A. Lauffenburger and Suzanne Gaudet

doi:10.1038/nrm2042

Nature Reviews Molecular Cell Biology 7, 803-812 (2006)

Linking data to models: data regression

Khuloud Jaqaman and Gaudenz Danuser

doi:10.1038/nrm2030

Nature Reviews Molecular Cell Biology 7, 813-819 (2006)

Physicochemical modelling of cell signalling pathways

Bree B. Aldridge, John M. Burke, Douglas A. Lauffenburger and Peter K. Sorger

doi:10.1038/ncb1497

Nature Cell Biology advance online publication, 22 October 2006

Data-driven modelling of signal-transduction networks

Kevin A. Janes and Michael B. Yaffe

doi:10.1038/nrm2041

Nature Reviews Molecular Cell Biology 7, 820-828 (2006)

Modelling microtubule patterns

Eric Karsenti, Fran´┐Żois Nédélec and Thomas Surrey

doi:10.1038/ncb1498

Nature Cell Biology advance online publication, 22 October 2006

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Perspective

Essay

Back to the future: education for systems-level biologists

Ned Wingreen and David Botstein

doi:10.1038/nrm2023

Nature Reviews Molecular Cell Biology 7, 829-832 (2006)

Tutorial

Imaging single molecules in living cells for systems biology

Yasushi Sako

doi:10.1038/msb4100100

Molecular Systems Biology 2, published online: 17 October 2006

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