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Modelling data across labs, genomes, space and time

Nature Cell Biology volume 8, pages 1190–1194 (2006)Cite this article

Abstract

Logical models and physical specifications provide the foundation for storage, management and analysis of complex sets of data, and describe the relationships between measured data elements and metadata — the contextual descriptors that define the primary data. Here, we use imaging applications to illustrate the purpose of the various implementations of data specifications and the requirement for open, standardized, data formats to facilitate the sharing of critical digital data and metadata.

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Figure 1: HeLa cell expressing GFP–coilin (green) and histone H2B–YFP (red).

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Acknowledgements

Work in the authors' laboratories is supported by grants from the Wellcome Trust, the Biotechnology and Biological Sciences Research Council (BBSRC) and Cancer Research UK (J.R.S.) and the National Institutes of Health (I.G.G. and S.E.L.). J.R.S. is a Wellcome Trust Senior Research Fellow.

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Authors and Affiliations

  1. Division of Gene Regulation and Expression, Wellcome Trust Biocentre, Faculty of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK

    Jason R. Swedlow

  2. Life Sciences Division, 1 Cyclotron Road MS-64R0121, Lawrence Berkeley National Laboratory, Berkeley, 94729, CA, USA

    Suzanna E. Lewis

  3. the Image Informatics and Computational Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Suite 4000, Baltimore, 21224, MD, USA

    Ilya G. Goldberg

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  3. Ilya G. Goldberg
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Swedlow, J., Lewis, S. & Goldberg, I. Modelling data across labs, genomes, space and time. Nat Cell Biol 8, 1190–1194 (2006). https://doi.org/10.1038/ncb1496

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