Welcome to the Nature Cell Biology and Nature Reviews Molecular Cell Biology joint Focus on Systems Biology: a User's Guide. This collection of Review-type articles are designed as highly accessible and practical guides to some of the most important approaches and challenges in systems biology. We acknowledge the financial support of Pfizer, The Mathworks, Merrimack, Novartis and Entelos. This Focus was produced in association with the US National Centers for Systems Biology and the journal Molecular Systems Biology.
Systems biology experts discuss the promise and the challenges of this emerging field in the accompanying Podcast, which was produced with support from Applied Precision.
Editorial
Reviews
Linking publication, gene and protein data
Paul Kersey and Rolf Apweiler
doi:10.1038/ncb1495
Nature Cell Biology advance online publication, 22 October 2006
Modelling data across labs, genomes, space and time
Jason R. Swedlow, Suzanna E. Lewis and Ilya G. Goldberg
doi:10.1038/ncb1496
Nature Cell Biology advance online publication, 22 October 2006
Collecting and organizing systematic sets of protein data
John G. Albeck, Gavin MacBeath, Forest M. White, Peter K. Sorger, Douglas A. Lauffenburger and Suzanne Gaudet
doi:10.1038/nrm2042
Nature Reviews Molecular Cell Biology 7, 803-812 (2006)
Linking data to models: data regression
Khuloud Jaqaman and Gaudenz Danuser
doi:10.1038/nrm2030
Nature Reviews Molecular Cell Biology 7, 813-819 (2006)
Physicochemical modelling of cell signalling pathways
Bree B. Aldridge, John M. Burke, Douglas A. Lauffenburger and Peter K. Sorger
doi:10.1038/ncb1497
Nature Cell Biology advance online publication, 22 October 2006
Data-driven modelling of signal-transduction networks
Kevin A. Janes and Michael B. Yaffe
doi:10.1038/nrm2041
Nature Reviews Molecular Cell Biology 7, 820-828 (2006)
Modelling microtubule patterns
Eric Karsenti, Fran�ois Nédélec and Thomas Surrey
doi:10.1038/ncb1498
Nature Cell Biology advance online publication, 22 October 2006
Perspective
Essay
Back to the future: education for systems-level biologists
Ned Wingreen and David Botstein
doi:10.1038/nrm2023
Nature Reviews Molecular Cell Biology 7, 829-832 (2006)
Tutorial
Imaging single molecules in living cells for systems biology
Yasushi Sako
doi:10.1038/msb4100100
Molecular Systems Biology 2, published online: 17 October 2006