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Checks and Balances in the Immune System

Immune cells drive a potent response after encounter with a pathogen. Nature Immunology presents a series of specially commissioned articles that discuss the metabolic requirements of immune responses and the regulatory circuits that balance eradication of the pathogen with minimal collateral damage to the host.

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Editorial

Focus on Checks and Balances in the Immune System

A balancing act p901

doi:10.1038/ni.2430


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Commentary

Focus on Checks and Balances in the Immune System

Maintaining system homeostasis: the third law of Newtonian immunology pp902 - 906

Ronald N. Germain

doi:10.1038/ni.2404


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Reviews

Focus on Checks and Balances in the Immune System

Metabolic checkpoints in activated T cells pp907 - 915

Ruoning Wang & Douglas R Green

doi:10.1038/ni.2386


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Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways pp916 - 924

Peter J Murray & Stephen T Smale

doi:10.1038/ni.2391


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From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines pp925 - 931

Jacques Banchereau, Virginia Pascual & Anne O'Garra

doi:10.1038/ni.2406


Focus on Checks and Balances in the Immune System

The price of immunity pp932 - 938

Romina S Goldszmid & Giorgio Trinchieri

doi:10.1038/ni.2422


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