Latest highlights

Article of the month

S1P1 blocks Treg cells
Article by Liu et al.*FREE ACCESS*

Regulatory T cells (Treg cells) are necessary for maintaining peripheral tolerance. Chi and colleagues show that the receptor S1P1 negatively regulates thymic Treg cells production and blocks Treg cells cell activity via an Akt-mTor pathway.


Advance online publication

Repairing Mtb-induced damage
Article by Divangahi et al.

Macrophages infected with virulent Mycobacterium tuberculosis die by necrosis. Remold and colleagues show that virulent M. tuberculosis promotes necrosis by damaging the plasma membrane and inhibiting its repair.


Advance online publication

Tonic signaling
Article by Delgado et al.

Tonic antigen receptor signaling contributes to the homeostasis of naive lymphocytes. Alarcón and colleagues show that resting lymphocytes transmit tonic antigen receptor signals through the GTPase TC21 to trigger the PI(3)K pathway.


Advance online publication

Mina represses Il4
Article by Okamoto et al.

Mouse strains show varying inherent biases to T helper type 2 (TH2) responses. Bix and colleagues identify Mina, a jumonji C protein, as a negative regulator of the gene encoding interleukin 4 whose expression inversely correlates with TH2 bias.


Advance online publication

A role for IgD
Article by Chen et al.

Mature B cells express immunoglobulin D, but its function is unknown. Cerutti and colleagues show that respiratory mucosal B cells secrete immunoglobulin D, which activates basophils and enhances antimicrobial function.


Focus

FOCUS ON Immune Signaling Cross-talk*FREE ACCESS*

Nature Immunology presents a focus on the complex interplay among signaling pathways operative in immune cells. The focus contains a specially commissioned overview, three review articles and two perspectives. Also included are highlights of recent research findings and several short comments—written by experts—providing in-depth insight into specific signal cross-talk points.



Extra navigation

Subscribe to Nature Immunology

Subscribe


Open Innovation Challenges

naturejobs

natureproducts


ADVERTISEMENT