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Maintaining Foxp3 expression
Article by Murai et al.

Interleukin 10–deficient mice develop spontaneous colitis. Kronenberg and colleagues find that interleukin 10 released by myeloid cells in the intestine is needed to maintain expression of the transcription factor Foxp3 in regulatory T cells.


Advance online publication

Itch destroys MAVS
Article by You et al.

The mitochondrial adaptor MAVS is necessary for the transmission of RIG-I and Mda5 antiviral signals. Jiang and colleagues show that PCBP2 negatively regulates MAVS stability by recruiting the L48-ubiquitinating enzyme AIP4, thereby preventing excessive cytokine responses.


Advance online publication

Nod2 in T cells
Article by Shaw et al.

Nod2 senses intracellular bacteria and is required for their eradication. Nuñez and co-workers now describe a T cell-intrinsic role for Nod2 in combating the intracellular parasite Toxoplasma gondii.


Advance online publication

Dec2 drives TH2 responses
Article by Yang et al.

The molecular mediators responsible for directing T helper type 2 (TH2) differentiation remain incompletely defined. Dong and co-workers find that the transcription factor Dec2 promotes expression of the transcription factor JunB and is essential for the induction of TH2 responses.


Advance online publication

MicroRNA managing TH-17 cells
Article by Du et al.

TH-17 cells are associated with multiple sclerosis (MS) pathogenesis. Pei and colleagues have now identified a TH-17 cell-associated microRNA, miR-326, whose expression correlates with disease severity.


Announcement

The Fondation IPSEN, Nature Immunology and Nature Reviews Molecular Cell Biology are pleased to announce an Emergence & Convergence mini-symposium:

Epigenetic Dynamics in the Immune System

February 19, 2010, The St. Anthony, San Antonio, TX, USA

For more information and to register, visit http://www.nature.com/natureconferences
/eandc/epigimm/index.html.



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