Nature Immunology - Current issue : November 2009 - Vol 10 No 11
Latest highlights
Article of the month
Maintaining Foxp3 expression
Article by MuraiInterleukin 10–deficient mice develop spontaneous colitis. Kronenberg and colleagues find that interleukin 10 released by myeloid cells in the intestine is needed to maintain expression of the transcription factor Foxp3 in regulatory T cells.
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News & Views by Unutmaz & PulendranAdvance online publication
Itch destroys MAVS
Article by YouThe mitochondrial adaptor MAVS is necessary for the transmission of RIG-I and Mda5 antiviral signals. Jiang and colleagues show that PCBP2 negatively regulates MAVS stability by recruiting the L48-ubiquitinating enzyme AIP4, thereby preventing excessive cytokine responses.
Advance online publication
Nod2 in T cells
Article by ShawNod2 senses intracellular bacteria and is required for their eradication. Nuñez and co-workers now describe a T cell-intrinsic role for Nod2 in combating the intracellular parasite Toxoplasma gondii.
Advance online publication
Dec2 drives TH2 responses
Article by YangThe molecular mediators responsible for directing T helper type 2 (TH2) differentiation remain incompletely defined. Dong and co-workers find that the transcription factor Dec2 promotes expression of the transcription factor JunB and is essential for the induction of TH2 responses.
Advance online publication
MicroRNA managing TH-17 cells
Article by DuTH-17 cells are associated with multiple sclerosis (MS) pathogenesis. Pei and colleagues have now identified a TH-17 cell-associated microRNA, miR-326, whose expression correlates with disease severity.
Announcement
The Fondation IPSEN, Nature Immunology and Nature Reviews Molecular Cell Biology are pleased to announce an Emergence & Convergence mini-symposium:
Epigenetic Dynamics in the Immune System
February 19, 2010, The St. Anthony, San Antonio, TX, USA
For more information and to register, visit http://www.nature.com/natureconferences
/eandc/epigimm/index.html.
