Nature Immunology - Current issue : July 2009 - Vol 10 No 7
Latest highlights
Article of the month
Regulatory T cells (Treg cells) are necessary for maintaining peripheral tolerance. Chi and colleagues show that the receptor S1P1 negatively regulates thymic Treg cells production and blocks Treg cells cell activity via an Akt-mTor pathway.
See also:
News & Views by Ohkura & SakaguchiAdvance online publication
Repairing Mtb-induced damage
Article by DivangahiMacrophages infected with virulent Mycobacterium tuberculosis die by necrosis. Remold and colleagues show that virulent M. tuberculosis promotes necrosis by damaging the plasma membrane and inhibiting its repair.
Advance online publication
Tonic signaling
Article by DelgadoTonic antigen receptor signaling contributes to the homeostasis of naive lymphocytes. Alarcón and colleagues show that resting lymphocytes transmit tonic antigen receptor signals through the GTPase TC21 to trigger the PI(3)K pathway.
Advance online publication
Mina represses Il4
Article by OkamotoMouse strains show varying inherent biases to T helper type 2 (TH2) responses. Bix and colleagues identify Mina, a jumonji C protein, as a negative regulator of the gene encoding interleukin 4 whose expression inversely correlates with TH2 bias.
Advance online publication
A role for IgD
Article by ChenMature B cells express immunoglobulin D, but its function is unknown. Cerutti and colleagues show that respiratory mucosal B cells secrete immunoglobulin D, which activates basophils and enhances antimicrobial function.
Focus
Nature Immunology presents a focus on the complex interplay among signaling pathways operative in immune cells. The focus contains a specially commissioned overview, three review articles and two perspectives. Also included are highlights of recent research findings and several short comments—written by experts—providing in-depth insight into specific signal cross-talk points.
