Focus


Focus on translating the microbiome

Researchers have generated more than 3.5 terabytes of human microbiome genomic information - more than 1,000 times that generated by the Human Genome Project. This Focus highlights progress in microbiome research and how these data might translate into a better understanding of human diseases and rational design of new therapies.

Top

In This Issue

Focus on translating the microbiome

In this issue pvii

doi:10.1038/nbt.2562


Top

Editorial

Focus on translating the microbiome

Laying better plans for mice p263

doi:10.1038/nbt.2560

Genetically defined germ-free animal models colonized with defined microbiota are crucial for progress in microbiome research.


Top

News

Data Page

Focus on translating the microbiome

Trends in microbiome research p277

Susan Jones

doi:10.1038/nbt.2546


Top

News Features

Focus on translating the microbiome

The startup bugs pp279 - 281

Charles Schmidt

doi:10.1038/nbt.2544

Burgeoning research on the human microbiome is facilitating the development of more mechanistically driven probiotics. Charles Schmidt investigates a smattering of probiotic- and microbiota-modifying therapeutic opportunities arising from commercial efforts.


Focus on translating the microbiome

A snapshot of the microbiome field pp282 - 283

Susan Jones

doi:10.1038/nbt.2545

A survey of leading scientists from academia and industry highlights notable papers that have garnered momentum in microbiome research.


Top

Features

Focus on translating the microbiome

Translating the human microbiome pp304 - 308

James Brown, Willem M de Vos, Peter S DiStefano, Joël Doré, Curtis Huttenhower, Rob Knight, Trevor D Lawley, Jeroen Raes & Peter Turnbaugh

doi:10.1038/nbt.2543

Nine experts discuss the challenges in translating current research on the human microbiome into strategies for disease prediction, diagnosis and therapy.


Focus on translating the microbiome

Medicines from microbiota pp309 - 315

Bernat Olle

doi:10.1038/nbt.2548

Five years after the launch of the Human Microbiome Project, several ventures are seeking to capitalize on the clinical promise of microbiome modulation. Commercialization of drugs that influence the human flora poses some unique scientific, translational and regulatory challenges.


Patents

Focus on translating the microbiome

Recent patent applications in bacteriotherapy p318

doi:10.1038/nbt.2559


Top