Nature Biotechnology - CURRENT ISSUE : June 2009 - Vol 27 No 6
LATEST HIGHLIGHTS
Advance Online Publication
Although multiple reaction monitoring mass spectrometry (MRM-MS) holds considerable promise for quantifying candidate protein biomarkers in blood, reproducibility of MRM-MS assays between laboratories has never been shown. Addona et al. assess the reproducibility, dynamic range and limits of detection and quantification of MRM-MS across multiple sites.
Advance Online Publication
siRNA delivery by minicells
Article by MacDiarmid et al.Drug resistance remains a major hurdle to effective cancer chemotherapy. MacDiarmid et al. show that bacterially derived minicells packaged with siRNAs suppress tumor drug resistance, increasing the efficacy of subsequent treatment with cytotoxic drugs.
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Advance Online Publication
Profiling RNA-binding proteins
Letter by Ray et al.Until now, determining the sequences recognized by an RNA-binding protein has been time and labor intensive. Ray et al. use a custom pool of >210k oligos that encode linear and stem-loop RNAs to rapidly determine the sequences bound by nine RNA-binding proteins.
Current Issue
Influenza virus attenuation
Letter by Perez et al.Traditional methods for modifying viruses to produce live attenuated vaccines are being updated with molecularly targeted approaches. Perez et al. attenuate influenza A viruses by introducing microRNA target sites into the coding region of the viral genome.
Impact Factor
The 2007 impact factor for Nature Biotechnology is 22.8, according to the ISI Journal Citation Reports. This places Nature Biotechnology first among primary research journals in the field of biotechnology.
Special Section
Transfection of siRNAs and miRNAs into cells can generate unexpected effects in the form of gene upregulation. By statistically analyzing published transfection experiments, Khan et al. explain these effects in terms of competition between transfected RNAs and endogenous miRNAs.
