Focus


Focus on the Ubiquitin-Proteasome System

The ubiquitin-proteasome system controls many cellular processes either by proteolytic or non-proteolytic means. The August 2005 issue of Nature Cell Biology presents a series of specially commissioned Reviews and Perspectives highlighting new insights into this pathway.

The Focus is sponsored by Millennium Pharmaceuticals and Boston Biochem.

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Editorial

Focus on the Ubiquitin-Proteasome System

Focusing on the ubiquitin-proteasome system p725

doi:10.1038/ncb0805-725


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Perspectives

Focus on the Ubiquitin-Proteasome System

Proteolysis: anytime, any place, anywhere? pp731 - 735

Jonathon Pines & Catherine Lindon

doi:10.1038/ncb0805-731


Focus on the Ubiquitin-Proteasome System

Protein quality control: chaperones culling corrupt conformations pp736 - 741

Amie J. McClellan, Stephen Tam, Daniel Kaganovich & Judith Frydman

doi:10.1038/ncb0805-736


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Reviews

Focus on the Ubiquitin-Proteasome System

Delivery of ubiquitinated substrates to protein-unfolding machines pp742 - 748

Suzanne Elsasser & Daniel Finley

doi:10.1038/ncb0805-742


Focus on the Ubiquitin-Proteasome System

Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics pp750 - 757

Donald S. Kirkpatrick, Carilee Denison & Steven P. Gygi

doi:10.1038/ncb0805-750


Focus on the Ubiquitin-Proteasome System

Ubiquitin signalling in the NF-κB pathway pp758 - 765

JZhijian J. Chen

doi:10.1038/ncb0805-758


Focus on the Ubiquitin-Proteasome System

ERAD: the long road to destruction pp766 - 772

Birgit Meusser, Christian Hirsch, Ernst Jarosch & Thomas Sommer

doi:10.1038/ncb0805-766