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Transcriptional repression in ES cells
Letter by Liang et al.

Nanog and Oct4 transcription factors regulate ES cell fate but exactly how is unclear. Songyang and colleagues show that Nanog and Oct4 act together in a novel NODE repressor complex that includes histone deacetylases HDAC1/2 and other repressors.


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Cytoplasmic p53 inhibits autophagy
Article by Tasdemir et al.

p53 transcription activity induces autophagy. Kroemer and colleagues show that cytoplasmic p53 represses autophagy in various cellular and animal models. Enhanced autophagy in p53-deficient cells improves their survival and mutiple autophagy inducers upregulate the degradation of cytoplasmic p53.


THE SIGNALING GATEWAY

The one-stop free resource for cell signaling researchers.
The Molecule Pages database provides free access to key facts about more than 3700 proteins involved in cellular signaling. Over 300 entries are enhanced by peer reviewed, expert authored summaries. The weekly updated Signaling Update includes free access to summaries of key articles, as well as a selection of papers from across the Nature journals and a continuously updated library of essential papers.


ANNOUNCEMENT

The Foundation IPSEN, Nature Immunology and Nature Cell Biology are pleased to announce an Emergence & Convergence mini-symposium: Cell Shape and Polarity: Lymphocytes and Beyond, September 29, 2008, Gleacher Center, Chicago, Illinois, USA.

http://www.nature.com/nature
conferences/eandc/
cellshape/index.html


This one-day mini-symposium aims to promote discussion between immunologists and cell biologists studying the molecular mechanisms underlying cell polarization, synapse formation and asymmetric cell division, as well as the influence of these processes on cell-fate determination and function.

Applications are currently being accepted.


ANNOUNCEMENT

Take advantage of Connotea bookmarks. Use the 'Save this Link' option on abstract and full-text pages to automatically store bookmarks on a central bibliographic bookmark server. Share your entire reference collection of bookmarks with thousands through Connotea. Organize bookmarks with tags, find new papers that other scientists have tagged, add comments and even export bibliographic bookmarks to desktop reference software!




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