Nature Cell Biology - ncb CURRENT ISSUE : May 2008 - Vol 10 No 5
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Transcriptional repression in ES cells
Letter by LiangNanog and Oct4 transcription factors regulate ES cell fate but exactly how is unclear. Songyang and colleagues show that Nanog and Oct4 act together in a novel NODE repressor complex that includes histone deacetylases HDAC1/2 and other repressors.
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Cytoplasmic p53 inhibits autophagy
Article by Tasdemirp53 transcription activity induces autophagy. Kroemer and colleagues show that cytoplasmic p53 represses autophagy in various cellular and animal models. Enhanced autophagy in p53-deficient cells improves their survival and mutiple autophagy inducers upregulate the degradation of cytoplasmic p53.
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ANNOUNCEMENT
The Foundation IPSEN, Nature Immunology and Nature Cell Biology are pleased to announce an Emergence & Convergence mini-symposium: Cell Shape and Polarity: Lymphocytes and Beyond, September 29, 2008, Gleacher Center, Chicago, Illinois, USA.
http://www.nature.com/nature
conferences/eandc/
cellshape/index.html
This one-day mini-symposium aims to promote discussion between immunologists and cell biologists studying the molecular mechanisms underlying cell polarization, synapse formation and asymmetric cell division, as well as the influence of these processes on cell-fate determination and function.
Applications are currently being accepted.
ANNOUNCEMENT
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