Nature Cell Biology - ncb Current issue : November 2009 - Vol 11 No 11
- Breast cancer KLF17
inhibits metastasis - Keeping telomeres off breaks
- IFT proteins govern immune synapses
Latest content
Advance online publication
Phosphorylation halts calcium entry in mitosis
Letter byDuring mitosis, store-operated Ca2+ entry (SOCE) is suppressed. Translocation of the ER Ca2+ sensor STIM1 to the plasma membrane is critical for SOCE activation and Putney and colleagues show that in mitotic cells, STIM1 is phosphorylated and fails to rearrange into near-plasma membrane puncta. Mutation of mitosis-specific phosphorylation sites in STIM1 rescues mitotic SOCE.
Advance online publication
IFT functions beyond cilia
Letter by FinettiBaldari and colleagues found that IFT20, known to control intraflagellar transport (IFT) during cilia biogenesis, is also expressed in lymphoid and myeloid non-ciliated cells. IFT20 is localized to the secretory pathway in T-lymphocytes and translocates to the immune synapse on antigen engagement to modulate the recycling of T-cell receptors.
Nature Milestones in
Light Microscopy
Light microscopy is the focus of the latest addition to our Milestone series. Light microscopy has provided the dominant data stream increasing our understanding of cell biology, and new powerful imaging tools and techniques continue to be developed. The Nature Milestones in Light Microscopy supplement contains a series of short articles presenting key developments, from the first microscope to 'super-resolution' imaging.
Microbial host cell subversion
To highlight advances in our understanding of the mechanisms by which microorganisms tailor cellular pathways to their own needs, Nature Reviews Microbiology and Nature Cell Biology present a set of specially commissioned articles that focus on some of the key pathways in host cells that are subverted by microorganisms during infection or colonization. These articles are freely available to registered users for 2 months after publication.
The Signaling Gateway
The one-stop free resource for cell signaling researchers.
The UCSD-Nature Molecule Pages has just published its 500th expert-authored, peer-reviewed Molecule Page. Each month, Nature Publishing Group publishes five to ten of these comprehensive, freely available review articles on a diverse set of signaling molecules ranging from transcription factors to membrane receptors. Our new user guide provides a quick overview of the anatomy of a published Molecule Page.
Structural Genomics Knowledgebase
A window onto the world of protein structure has opened with the new, free PSI-Nature Structural Genomics Knowledgebase (PSI SGKB). The site is designed to turn the products of the Protein Structure Initiative into knowledge that is important for understanding living systems and disease, complemented with structural biology updates from Nature Publishing Group.
