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The ubiquitin-proteasome system controls many cellular processes
either by proteolytic or non-proteolytic means.
The August 2005 issue of Nature Cell Biology presents a series of specially commissioned
Reviews and Perspectives highlighting new insights into this pathway.
The Focus is sponsored by Millennium Pharmaceuticals and Boston Biochem.
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| Editorial | Top |
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Focusing on the ubiquitin–proteasome system p725
doi:10.1038/ncb0805-725
Full text | PDF
(108K)
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| Perspectives | Top |
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Proteolysis: anytime, any place, anywhere? pp731 - 735
Jonathon Pines
& Catherine Lindon
doi:10.1038/ncb0805-731
Abstract | Full text | PDF
(238K)
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Protein quality control: chaperones culling corrupt conformations pp736 - 741
Amie J. McClellan, Stephen Tam, Daniel Kaganovich
& Judith Frydman
doi:10.1038/ncb0805-736
Abstract | Full text | PDF
(350K)
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| Reviews | Top |
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Delivery of ubiquitinated substrates to protein-unfolding machines pp742 - 749
Suzanne Elsasser
& Daniel Finley
doi:10.1038/ncb0805-742
Abstract | Full text | PDF
(343K)
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Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics pp750 - 757
Donald S. Kirkpatrick, Carilee Denison
& Steven P. Gygi
doi:10.1038/ncb0805-750
Abstract | Full text | PDF
(354K)
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Ubiquitin signalling in the NF- B pathway pp758 - 765
Zhijian J. Chen
doi:10.1038/ncb0805-758
Abstract | Full text | PDF
(480K)
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ERAD: the long road to destruction pp766 - 772
Birgit Meusser, Christian Hirsch, Ernst Jarosch
& Thomas Sommer
doi:10.1038/ncb0805-766
Abstract | Full text | PDF
(376K)
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| News and Views | Top |
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Substrate specificity: PI(3)K has it both ways pp773 - 774
Jonathan M. Backer
doi:10.1038/ncb0805-773
Abstract | Full text | PDF
(184K)
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An actin fishnet for DNA pp775 - 776
Ann L. Miller
& William M. Bement
doi:10.1038/ncb0805-775
Abstract | Full text | PDF
(174K)
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Rac and cell migration: CDM proteins integrate signals pp777 - 778
Henry R. Bourne
doi:10.1038/ncb0805-777
Abstract | Full text | PDF
(168K)
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Cdk1: the dominant sibling of Cdk2 pp779 - 781
Tarig Bashir
& Michele Pagano
doi:10.1038/ncb0805-779
Abstract | Full text | PDF
(314K)
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MicroRNAs diversify in Drosophila development p781
Alison Schuldt
doi:10.1038/ncb0805-781
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(253K)
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| Book Review | Top |
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Becoming a cell voyeur p783
Reviewed by: Julie C. Canman
doi:10.1038/ncb0805-783
Full text | PDF
(118K)
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| Articles | Top |
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Protein kinase activity of phosphoinositide 3-kinase regulates  -adrenergic receptor endocytosis pp785 - 796
Sathyamangla V. Naga Prasad, Arundathi Jayatilleke, Aasakiran Madamanchi
& Howard A. Rockman
Published online: 10 July 2005 | doi:10.1038/ncb1278
Abstract | Full text | PDF
(2,209K)
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See also: News and Views by Backer |
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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling pp797 - 807
Jean-François Côté, Andrea B. Motoyama, Jason A. Bush
& Kristiina Vuori
Published online: 17 July 2005 | doi:10.1038/ncb1280
Abstract | Full text | PDF
(1,311K)
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See also: News and Views by Bourne |
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Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes pp808 - 816
James I. Elliott, Annmarie Surprenant, Federica M. Marelli-Berg, Joanne C. Cooper, Robin L. Cassady-Cain, Carol Wooding, Kenneth Linton, Denis R. Alexander
& Christopher F. Higgins
Published online: 17 July 2005 | doi:10.1038/ncb1279
Abstract | Full text | PDF
(1,154K)
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| Letters | Top |
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Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol pp817 - 822
Harald W. Platta, Silke Grunau, Katja Rosenkranz, Wolfgang Girzalsky
& Ralf Erdmann
Published online: 10 July 2004 | doi:10.1038/ncb1281
Abstract | Full text | PDF
(516K)
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Temporal and spatial control of nucleophosmin by the Ran–Crm1 complex in centrosome duplication pp823 - 830
Wei Wang, Anuradha Budhu, Marshonna Forgues
& Xin Wei Wang
Published online: 24 July 2005 | doi:10.1038/ncb1282
Abstract | Full text | PDF
(748K)
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Cdc2–cyclin E complexes regulate the G1/S phase transition pp831 - 836
Eiman Aleem, Hiroaki Kiyokawa
& Philipp Kaldis
Published online: 10 July 2005 | doi:10.1038/ncb1284
Abstract | Full text | PDF
(2,179K)
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See also: News and Views by Bashir & Pagano |
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Prohibitin is required for Ras-induced Raf–MEK–ERK activation and epithelial cell migration pp837 - 843
Krishnaraj Rajalingam, Christian Wunder, Volker Brinkmann, Yuri Churin, Mirko Hekman, Claudia Sievers, Ulf R. Rapp
& Thomas Rudel
Published online: 24 July 2005 | doi:10.1038/ncb1283
Abstract | Full text | PDF
(756K)
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