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| Focus | Top |
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The ubiquitin-proteasome system controls many cellular processes
either by proteolytic or non-proteolytic means.
The August 2005 issue of Nature Cell Biology presents a series of specially commissioned
Reviews and Perspectives highlighting new insights into this pathway.
The Focus is sponsored by Millennium Pharmaceuticals and Boston Biochem.
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| Editorial | Top |
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Focusing on the ubiquitin–proteasome system p725 doi:10.1038/ncb0805-725 Full text | PDF
(108K)
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| Perspectives | Top |
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Proteolysis: anytime, any place, anywhere? pp731 - 735 Jonathon Pines
& Catherine Lindon doi:10.1038/ncb0805-731 Abstract | Full text | PDF
(238K)
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Protein quality control: chaperones culling corrupt conformations pp736 - 741 Amie J. McClellan, Stephen Tam, Daniel Kaganovich
& Judith Frydman doi:10.1038/ncb0805-736 Abstract | Full text | PDF
(350K)
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| Reviews | Top |
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Delivery of ubiquitinated substrates to protein-unfolding machines pp742 - 749 Suzanne Elsasser
& Daniel Finley doi:10.1038/ncb0805-742 Abstract | Full text | PDF
(343K)
| Supplementary Information |
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Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics pp750 - 757 Donald S. Kirkpatrick, Carilee Denison
& Steven P. Gygi doi:10.1038/ncb0805-750 Abstract | Full text | PDF
(354K)
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Ubiquitin signalling in the NF- B pathway pp758 - 765 Zhijian J. Chen doi:10.1038/ncb0805-758 Abstract | Full text | PDF
(480K)
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ERAD: the long road to destruction pp766 - 772 Birgit Meusser, Christian Hirsch, Ernst Jarosch
& Thomas Sommer doi:10.1038/ncb0805-766 Abstract | Full text | PDF
(376K)
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| News and Views | Top |
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Substrate specificity: PI(3)K has it both ways pp773 - 774 Jonathan M. Backer doi:10.1038/ncb0805-773 Abstract | Full text | PDF
(184K)
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An actin fishnet for DNA pp775 - 776 Ann L. Miller
& William M. Bement doi:10.1038/ncb0805-775 Abstract | Full text | PDF
(174K)
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Rac and cell migration: CDM proteins integrate signals pp777 - 778 Henry R. Bourne doi:10.1038/ncb0805-777 Abstract | Full text | PDF
(168K)
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Cdk1: the dominant sibling of Cdk2 pp779 - 781 Tarig Bashir
& Michele Pagano doi:10.1038/ncb0805-779 Abstract | Full text | PDF
(314K)
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MicroRNAs diversify in Drosophila development p781 Alison Schuldt doi:10.1038/ncb0805-781 Full text | PDF
(253K)
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| Book Review | Top |
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Becoming a cell voyeur p783 Reviewed by: Julie C. Canman doi:10.1038/ncb0805-783 Full text | PDF
(118K)
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| Articles | Top |
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Protein kinase activity of phosphoinositide 3-kinase regulates -adrenergic receptor endocytosis pp785 - 796 Sathyamangla V. Naga Prasad, Arundathi Jayatilleke, Aasakiran Madamanchi
& Howard A. Rockman Published online: 10 July 2005 | doi:10.1038/ncb1278 Abstract | Full text | PDF
(2,209K)
| Supplementary Information See also: News and Views by Backer |
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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling pp797 - 807 Jean-François Côté, Andrea B. Motoyama, Jason A. Bush
& Kristiina Vuori Published online: 17 July 2005 | doi:10.1038/ncb1280 Abstract | Full text | PDF
(1,311K)
| Supplementary Information See also: News and Views by Bourne |
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Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes pp808 - 816 James I. Elliott, Annmarie Surprenant, Federica M. Marelli-Berg, Joanne C. Cooper, Robin L. Cassady-Cain, Carol Wooding, Kenneth Linton, Denis R. Alexander
& Christopher F. Higgins Published online: 17 July 2005 | doi:10.1038/ncb1279 Abstract | Full text | PDF
(1,154K)
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| Letters | Top |
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Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol pp817 - 822 Harald W. Platta, Silke Grunau, Katja Rosenkranz, Wolfgang Girzalsky
& Ralf Erdmann Published online: 10 July 2004 | doi:10.1038/ncb1281 Abstract | Full text | PDF
(516K)
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Temporal and spatial control of nucleophosmin by the Ran–Crm1 complex in centrosome duplication pp823 - 830 Wei Wang, Anuradha Budhu, Marshonna Forgues
& Xin Wei Wang Published online: 24 July 2005 | doi:10.1038/ncb1282 Abstract | Full text | PDF
(748K)
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Cdc2–cyclin E complexes regulate the G1/S phase transition pp831 - 836 Eiman Aleem, Hiroaki Kiyokawa
& Philipp Kaldis Published online: 10 July 2005 | doi:10.1038/ncb1284 Abstract | Full text | PDF
(2,179K)
| Supplementary Information See also: News and Views by Bashir & Pagano |
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Prohibitin is required for Ras-induced Raf–MEK–ERK activation and epithelial cell migration pp837 - 843 Krishnaraj Rajalingam, Christian Wunder, Volker Brinkmann, Yuri Churin, Mirko Hekman, Claudia Sievers, Ulf R. Rapp
& Thomas Rudel Published online: 24 July 2005 | doi:10.1038/ncb1283 Abstract | Full text | PDF
(756K)
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