Focus
Focus on Epigenetics
- Focus issue:
- October 2010 Volume 28, No 10
Rapid progress is being made in our understanding of epigenetic modifications in nuclear organization and chromosome packaging that affect development, disease and natural variation. Epigenetic modifications directly influence gene expression and - in many instances - show a much stronger correlation with phenotypes than mutations in the primary DNA sequence. At the same time, new technologies are emerging that facilitate the analysis of genome-wide epigenetic changes and their role in cellular reprogramming in stem and somatic cells. This focus examines how these recent advances are being applied in biotechnology applications and beyond.
Editorial
Focus on Epigenetics
Making a mark - p1031
doi:10.1038/nbt1010-1031
High-throughput technologies are enabling epigenetic modifications to be mapped on a genome-wide scale, but whether such knowledge can be rapidly translated into biomedical applications remains unclear.
Abstract - | Full Text - Making a mark | PDF (133 KB) - Making a mark
Opinion and Comment
Commentary
Focus on Epigenetics
Linking cell signaling and the epigenetic machinery - pp1033 - 1038
Helai P Mohammad & Stephen B Baylin
doi:10.1038/nbt1010-1033
One of the biggest gaps in our knowledge about epigenomes is how their interplay with cellular signaling influences development, adult cellular differentiation and disease.
Abstract - | Full Text - Linking cell signaling and the epigenetic machinery | PDF (620 KB) - Linking cell signaling and the epigenetic machinery
Focus on Epigenetics
Tackling the epigenome: challenges and opportunities for collaboration - pp1039 - 1044
John S Satterlee, Dirk Schübeler & Huck-Hui Ng
doi:10.1038/nbt1010-1039
What are the key considerations to take into account when large-scale epigenomics projects are being implemented?
Abstract - | Full Text - Tackling the epigenome: challenges and opportunities for collaboration | PDF (204 KB) - Tackling the epigenome: challenges and opportunities for collaboration
Focus on Epigenetics
The NIH Roadmap Epigenomics Mapping Consortium - pp1045 - 1048
Bradley E Bernstein, John A Stamatoyannopoulos, Joseph F Costello, Bing Ren, Aleksandar Milosavljevic, Alexander Meissner, Manolis Kellis, Marco A Marra, Arthur L Beaudet, Joseph R Ecker, Peggy J Farnham, Martin Hirst, Eric S Lander, Tarjei S Mikkelsen & James A Thomson
doi:10.1038/nbt1010-1045
The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.
Abstract - | Full Text - The NIH Roadmap Epigenomics Mapping Consortium | PDF (445 KB) - The NIH Roadmap Epigenomics Mapping Consortium
Focus on Epigenetics
Epigenomics reveals a functional genome anatomy and a new approach to common disease - pp1049 - 1052
Andrew P Feinberg
doi:10.1038/nbt1010-1049
Epigenomics provides the context for understanding the function of genome sequence, analogous to the functional anatomy of the human body provided by Vesalius a half-millennium ago. Much of the seemingly inconclusive genetic data related to common diseases could therefore become meaningful in an epigenomic context.
Abstract - | Full Text - Epigenomics reveals a functional genome anatomy and a new approach to common disease | PDF (180 KB) - Epigenomics reveals a functional genome anatomy and a new approach to common disease
Computational Biology
Commentary
Focus on Epigenetics
Putting epigenome comparison into practice - pp1053 - 1056
Aleksandar Milosavljevic
doi:10.1038/nbt1010-1053
Comparative analysis of epigenomes offers new opportunities to understand cellular differentiation, mutation effects and disease processes. But the scale and heterogeneity of epigenetic data present numerous computational challenges.
Abstract - | Full Text - Putting epigenome comparison into practice | PDF (271 KB) - Putting epigenome comparison into practice
Research
Reviews
Focus on Epigenetics
Epigenetic modifications and human disease - pp1057 - 1068
Anna Portela & Manel Esteller
doi:10.1038/nbt.1685
Abstract - | Full Text - Epigenetic modifications and human disease | PDF (858 KB) - Epigenetic modifications and human disease
Focus on Epigenetics
Epigenetic modifications as therapeutic targets - pp1069 - 1078
Theresa K Kelly, Daniel D De Carvalho & Peter A Jones
doi:10.1038/nbt.1678
Abstract - | Full Text - Epigenetic modifications as therapeutic targets | PDF (1,020 KB) - Epigenetic modifications as therapeutic targets
Focus on Epigenetics
Epigenetic modifications in pluripotent and differentiated cells - pp1079 - 1088
Alexander Meissner
doi:10.1038/nbt.1684
Abstract - | Full Text - Epigenetic modifications in pluripotent and differentiated cells | PDF (996 KB) - Epigenetic modifications in pluripotent and differentiated cells
Focus on Epigenetics
Genomics tools for unraveling chromosome architecture - pp1089 - 1095
Bas van Steensel & Job Dekker
doi:10.1038/nbt.1680
Abstract - | Full Text - Genomics tools for unraveling chromosome architecture | PDF (1,693 KB) - Genomics tools for unraveling chromosome architecture
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