Featured
-
-
Article
| Open AccessCaffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics
- Aye Chan Khine Lin
- , Ponsawan Netcharoensirisuk
- & Supakarn Chamni
-
Article
| Open AccessInfluence of tramadol on bacterial burden in the standard neutropenic thigh infection model
- K. Rox
-
Article
| Open AccessMagnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery
- Rezvan Ahangarani-Farahani
- , Mohammad Ali Bodaghifard
- & Sajad Asadbegi
-
Article
| Open AccessLipid-A-dependent and cholesterol-dependent dynamics properties of liposomes from gram-negative bacteria in ESKAPE
- Juan Felipe Franco-Gonzalez
- , Alejandra Matamoros-Recio
- & Sonsoles Martin-Santamaria
-
Article
| Open AccessProline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers
- Monika Kopečná
- , Miloslav Macháček
- & Kateřina Vávrová
-
Article
| Open AccessDesign of amino acid- and carbohydrate-based anticancer drugs to inhibit polymerase η
- Sepideh Kalhor
- & Alireza Fattahi
-
Article
| Open AccessNeuroprotective metabolites via fungal biotransformation of a novel sapogenin, cyclocephagenol
- Melis Küçüksolak
- , Göklem Üner
- & Erdal Bedir
-
Article
| Open AccessExpression of membrane Hsp90 is a molecular signature of T cell activation
- Scott A. Scarneo
- , Aaron P. Smith
- & Timothy A. J. Haystead
-
Article
| Open AccessSynergy of R-(–)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation
- Oliver Riester
- , Pia Burkhardtsmaier
- & Magnus S. Schmidt
-
Article
| Open AccessAn efflux-susceptible antibiotic-adjuvant with systemic efficacy against mouse infections
- Ohad Meir
- , Fadia Zaknoon
- & Amram Mor
-
Article
| Open AccessSynthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX
- Abdelrahman I. Zain-Alabdeen
- , Tarek F. El-Moselhy
- & Mervat H. El-Hamamsy
-
Article
| Open AccessInfluence of Huangqin Decoction on the immune function and fecal microbiome of chicks after experimental infection with Escherichia coli O78
- Junyan Wang
- , Rui Li
- & Xichun Zhang
-
Article
| Open AccessBis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors
- Asif Rasool
- , Zahra Batool
- & Ahmed Al-Harrasi
-
Article
| Open AccessSemisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria
- Ilona Bereczki
- , Vladimir Vimberg
- & Anikó Borbás
-
Article
| Open AccessNovel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
- Sven Ruf
- , Sridharan Rajagopal
- & Aimo Kannt
-
Article
| Open AccessA new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
- Deniz Cansen Kahraman
- , Ebru Bilget Guven
- & Rengul Cetin Atalay
-
Article
| Open AccessDevelopment of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis
- Joanna Fedorowicz
- , Dagmara Bazar
- & Jarosław Sączewski
-
Article
| Open AccessNovel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening
- Anuradha Kumar
- , Somsundaram Chettiar
- & Tanya Parish
-
Article
| Open AccessMulti-spectroscopic, thermodynamic, and molecular docking/dynamic approaches for characterization of the binding interaction between calf thymus DNA and palbociclib
- Galal Magdy
- , Moataz A. Shaldam
- & Heba Elmansi
-
Article
| Open AccessIdentification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
- Eric R. Goedken
- , Maria A. Argiriadi
- & Chaohong Sun
-
Article
| Open AccessThe impact of H/D exchange on the thermal and structural properties as well as high-pressure relaxation dynamics of melatonin
- Paulina Jesionek
- , Barbara Hachuła
- & Ewa Kamińska
-
Article
| Open AccessDesign, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
- Milad Noori
- , Ali Davoodi
- & Mohammad Mahdavi
-
Article
| Open AccessNovel covalent and non-covalent complex-based pharmacophore models of SARS-CoV-2 main protease (Mpro) elucidated by microsecond MD simulations
- Yasser Hayek-Orduz
- , Andrés Felipe Vásquez
- & Andrés Fernando González Barrios
-
Article
| Open AccessNon-apoptotic cell death induction via sapogenin based supramolecular particles
- Göklem Üner
- , Erdal Bedir
- & Petek Ballar Kırmızıbayrak
-
Article
| Open AccessNovel psoralen derivatives as anti-breast cancer agents and their light-activated cytotoxicity against HER2 positive breast cancer cells
- Chiphada Aekrungrueangkit
- , Sirilak Wangngae
- & Tanatorn Khotavivattana
-
Article
| Open AccessAn open-source smartphone app for the quantitative evaluation of thin-layer chromatographic analyses in medicine quality screening
- Cathrin Hauk
- , Mark Boss
- & Lutz Heide
-
Article
| Open AccessDevelopment a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning
- Walid Kamal Abdelbasset
- , Safaa M. Elkholi
- & Mohammed A. S. Abourehab
-
Article
| Open Access(+)-Usnic acid and its salts, inhibitors of SARS‐CoV‐2, identified by using in silico methods and in vitro assay
- Eunseok Oh
- , Weihong Wang
- & Heonjoong Kang
-
Article
| Open AccessOptimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
- Andrew A. Bieberich
- , Tuomo Laitinen
- & Christopher R. M. Asquith
-
Article
| Open AccessDesign, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity
- Wagdy M. Eldehna
- , Mahmoud A. El Hassab
- & Hatem A. Abdel-Aziz
-
Article
| Open AccessDiscrimination of Curculigo orchioides Rhizoma and Curculigo glabrescens Rhizoma using stable isotope and mineral element analyses coupled with chemometrics
- Yushi Liu
- , Yiping Guo
- & Li Guo
-
Article
| Open AccessConjugates of urolithin A with NSAIDs, their stability, cytotoxicity, and anti-inflammatory potential
- Maciej Korczak
- , Piotr Roszkowski
- & Jakub P. Piwowarski
-
Article
| Open AccessExploring the molecular interaction of mebendazole with bovine serum albumin using multi-spectroscopic approaches and molecular docking
- Reem N. El Gammal
- , Heba Elmansi
- & Mohammed E. A. Hammouda
-
Article
| Open AccessColloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor
- Ivana Šišoláková
- , Ondrej Petruš
- & Renáta Oriňaková
-
Article
| Open AccessSynthesis of (E)-2-(1H-tetrazole-5-yl)-3-phenylacrylenenitrile derivatives catalyzed by new ZnO nanoparticles embedded in a thermally stable magnetic periodic mesoporous organosilica under green conditions
- Sajedeh Safapoor
- , Mohammad G. Dekamin
- & M. Reza Naimi-Jamal
-
Article
| Open AccessA potent estrogen receptor and microtubule specific purine-benzothiazole-based fluorescent molecular probe induces apoptotic death of breast cancer cells
- Surajit Barman
- , Subhajit Ghosh
- & Surajit Ghosh
-
Article
| Open AccessMolecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids
- Ting Jiang
- , Ya-Nan Cao
- & Ling-Li Zheng
-
Article
| Open AccessExamination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine
- Pavlína Hašková
- , Lenka Applová
- & Tomáš Šimůnek
-
Article
| Open AccessInvestigating the ligand agonism and antagonism at the D2long receptor by dynamic mass redistribution
- Lisa Forster
- & Steffen Pockes
-
Article
| Open AccessImpact of sucroferric oxyhydroxide on the oral and intestinal microbiome in hemodialysis patients
- Mohamed M. H. Abdelbary
- , Christoph Kuppe
- & Georg Conrads
-
Article
| Open AccessCyanoacetohydrazide linked to 1,2,3-triazole derivatives: a new class of α-glucosidase inhibitors
- Aida Iraji
- , Diba Shareghi-Brojeni
- & Mina Saeedi
-
Article
| Open AccessChitosan-EDTA-Cellulose network as a green, recyclable and multifunctional biopolymeric organocatalyst for the one-pot synthesis of 2-amino-4H-pyran derivatives
- Negin Rostami
- , Mohammad G. Dekamin
- & Hamidreza Fanimoghadam
-
Article
| Open AccessIndeterminacy of cannabis impairment and ∆9-tetrahydrocannabinol (∆9-THC) levels in blood and breath
- Gregory T. Wurz
- & Michael W. DeGregorio
-
Article
| Open AccessStructure-based assessment and druggability classification of protein–protein interaction sites
- Lara Alzyoud
- , Richard A. Bryce
- & Mohammad A. Ghattas
-
Article
| Open AccessIdentification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection
- Maria L. Faquetti
- , Francesca Grisoni
- & Andrea M. Burden
-
Article
| Open AccessImprovement in sensitivity for lateral flow immunoassay of ferritin using novel device design based on gold-enhanced gold nanoparticles
- Pattarachaya Preechakasedkit
- , Kanyapat Teekayupak
- & Nipapan Ruecha
-
Article
| Open AccessDecoding the protein–ligand interactions using parallel graph neural networks
- Carter Knutson
- , Mridula Bontha
- & Neeraj Kumar
-
Article
| Open AccessTotal synthesis and antimicrobial evaluation of (+)-hygrophorone B12 and its analogues
- Takaaki Kamishima
- , Masato Suzuki
- & Hitoshi Kasai
-
Article
| Open AccessNaloxone’s dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain
- Yeona Kang
- , Kelly A. O’Conor
- & Nora D. Volkow