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Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies
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Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches
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Synthesis of natural product hybrids by the Ugi reaction in complex media containing plant extracts
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Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
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Design, synthesis and evaluation of novel 2-oxoindoline-based acetohydrazides as antitumor agents
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Identification of stomatal-regulating molecules from de novo arylamine collection through aromatic C–H amination
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Comprehensive exploration of chemical space using trisubstituted carboranes
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Identification of novel inhibitors of Keap1/Nrf2 by a promising method combining protein–protein interaction-oriented library and machine learning
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Exploring food contents in scientific literature with FoodMine
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PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor
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Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation
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Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
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Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors
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Striking essential oil: tapping into a largely unexplored source for drug discovery
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An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica
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A suicide inhibitor of nematode trehalose-6-phosphate phosphatases
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Amphiphilic Triazine Polymer Derivatives as Antibacterial And Anti-atopic Agents in Mice Model
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SLTChemDB: A database of chemical compounds present in Smokeless tobacco products
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Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities
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High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq
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Varied Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy
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Kaempferol mitigates Endoplasmic Reticulum Stress Induced Cell Death by targeting caspase 3/7
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Compositional Bias in Naïve and Chemically-modified Phage-Displayed Libraries uncovered by Paired-end Deep Sequencing
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Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease
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A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies
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Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target
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Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence
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One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
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A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis
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Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
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Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
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Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
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Novel long-chain compounds with both immunomodulatory and MenA inhibitory activities against Staphylococcus aureus and its biofilm
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Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors
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A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines
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An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces
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Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily
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Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation