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Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
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EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
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Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling
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Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes
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PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo
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Network pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism
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Tamoxifen associated to the conservative CKD treatment promoted additional antifibrotic effects on experimental hypertensive nephrosclerosis
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Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management
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Hippocampal expression of the cannabinoid receptor type 1 in canine epilepsy
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The telomerase activator TA-65 protects from cigarette smoke-induced small airway remodeling in mice through extra-telomeric effects
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Defining the timeline of periostin upregulation in cardiac fibrosis following acute myocardial infarction in mice
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The module triad: a novel network biology approach to utilize patients’ multi-omics data for target discovery in ulcerative colitis
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Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi
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Large scale screening of CRISPR guide RNAs using an optimized high throughput robotics system
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Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study
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Reciprocal perspective as a super learner improves drug-target interaction prediction (MUSDTI)
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KOPI: Kinase inhibitOr Proteome Impact analysis
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Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform
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Sulfaphenazole reduces thermal and pressure injury severity through rapid restoration of tissue perfusion
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Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis
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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
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