Learning and memory articles within Nature

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  • Article |

    Using a Bayesian learning approach, a study tracks the spatial representations by individual hippocampal cells over time in freely moving rats, and provides insights into how ensemble patterns form and reconfigure during sleep.

    • Kourosh Maboudi
    • , Bapun Giri
    •  & Kamran Diba

  • Article
    | Open Access

    Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage repair, results in their recruitment to memory circuits.

    • Vladimir Jovasevic
    • , Elizabeth M. Wood
    •  & Jelena Radulovic

  • Article
    | Open Access

    Spatial and single-cell transcriptomic analyses of the mouse basolateral amygdala reveal transcriptomic signatures, spatial resolution and interactions of cells that constitute the memory engram, including crucial neuron–astrocyte interactions.

    • Wenfei Sun
    • , Zhihui Liu
    •  & Stephen R. Quake

  • Article |

    Studies in mice show that observational fear learning is encoded by neurons in the dorsomedial prefrontal cortex in a manner that is distinct from the encoding of fear learned by direct experience.

    • Shana E. Silverstein
    • , Ruairi O’Sullivan
    •  & Andrew Holmes

  • Article |

    Offline cortical reactivations predict the gradual drift and separation in sensory cortical response patterns and may enhance sensory discrimination.

    • Nghia D. Nguyen
    • , Andrew Lutas
    •  & Mark L. Andermann

  • Article
    | Open Access

    Initial dopamine self-stimulations reinforced not only the stimulation-producing target action, but also actions similar to the target action and actions that occurred a few seconds before stimulation, and repeated pairings led to a gradual refinement of the behavioural repertoire to home in on the target actions.

    • Jonathan C. Y. Tang
    • , Vitor Paixao
    •  & Rui M. Costa

  • Article
    | Open Access

    In bats engaged in spontaneous collective spatial behaviour, a robust spatial structure emerges at the group level whereby behaviour is anchored to specific locations, movement patterns and individual social preferences, and many hippocampal neurons are tuned to key features of group dynamics.

    • Angelo Forli
    •  & Michael M. Yartsev

  • Article
    | Open Access

    Behavioural electrophysiological and transcriptomic studies in mice show that psychedelic drugs reopen the social reward learning critical period and suggest that this involves reorganization of the extracellular matrix.

    • Romain Nardou
    • , Edward Sawyer
    •  & Gül Dölen

  • Article
    | Open Access

    Rule-shift behavioural experiments in mice demonstrate that callosal projections of parvalbumin-expressing neurons switch prefrontal circuits from maintenance mode to rule-learning mode by gating inputs from other callosal inputs that maintain previous rule representations.

    • Kathleen K. A. Cho
    • , Jingcheng Shi
    •  & Vikaas S. Sohal

  • Article
    | Open Access

    Experiments in rats show that spatial representations in the hippocampus are closely coordinated with the forelimb stepping cycle, particularly when spatial decisions are approaching, and provide insight into how this synchronization supports information processing.

    • Abhilasha Joshi
    • , Eric L. Denovellis
    •  & Loren M. Frank

  • Article
    | Open Access

    Analysis of data collected from mice learning a trace conditioning paradigm shows that phasic dopamine activity in the brain can regulate direct learning of behavioural policies, and dopamine sets an adaptive learning rate rather than an error-like teaching signal.

    • Luke T. Coddington
    • , Sarah E. Lindo
    •  & Joshua T. Dudman

  • Article
    | Open Access

    A study demonstrates that plasticity in the head direction system in Drosophila is modulated by dopamine, which increases learning when reorienting movements are bringing in new spatial information.

    • Yvette E. Fisher
    • , Michael Marquis
    •  & Rachel I. Wilson

  • Article
    | Open Access

    Analysis of the activity of CA1 cells in mice performing a learning task shows that the entorhinal cortex signals behavioural timescale synaptic plasticity to generate learning-related changes in the hippocampus.

    • Christine Grienberger
    •  & Jeffrey C. Magee

  • Article
    | Open Access

    During rapid behavioural switches in flying bats, hippocampal neurons can rapidly switch their core computation to represent the relevant behavioural variables, supporting behavioural flexibility.

    • Ayelet Sarel
    • , Shaked Palgi
    •  & Nachum Ulanovsky

  • Article |

    Longitudinal imaging and functional perturbations during behaviour identified a brain region that represents constituent features of a contextual memory and enables feature-mediated memory recall.

    • Nakul Yadav
    • , Chelsea Noble
    •  & Priyamvada Rajasethupathy

  • Article |

    Noradrenaline-expressing neurons in the locus coeruleus in mouse facilitate task execution and encode reinforcement in learning tasks, via partially modular projections to the cortex.

    • Vincent Breton-Provencher
    • , Gabrielle T. Drummond
    •  & Mriganka Sur

  • Article |

    A molecular mechanism involving CCR5 and CCL5 determines the temporal window in which a memory can be linked with subsequent memories, and in aged mice an increase in CCR5 is associated with defects in memory linking.

    • Yang Shen
    • , Miou Zhou
    •  & Alcino J. Silva

  • Article |

    The hippocampal code in freely flying bats is highly stable over days and across contexts if behaviour is taken into account.

    • William A. Liberti III
    • , Tobias A. Schmid
    •  & Michael M. Yartsev

  • Article |

    In rhesus monkeys, learning of a motor task is accompanied by uniform changes in preparatory activity in motor cortex that are orthogonal to the force-predictive neural state subspace.

    • Xulu Sun
    • , Daniel J. O’Shea
    •  & Krishna V. Shenoy

  • Article |

    In memory consolidation, the hippocampus has a unique way to preferentially amplify behaviour-relevant information that entails ‘replaying’ this information during periods of rest.

    • Satoshi Terada
    • , Tristan Geiller
    •  & Attila Losonczy

  • Article |

    Single-cell tracing and optogenetics manipulation in mice are used to show how spatial tuning of individual pyramidal cells in CA1 can propagate to and be amplified by their local subnetwork of neurons.

    • Tristan Geiller
    • , Sadra Sadeh
    •  & Attila Losonczy

  • Article
    | Open Access

    Dedicated cells in the hippocampus and entorhinal cortex map an animal s instantaneous position in space; by contrast, its future goal location is represented in the orbitofrontal cortex, a structure within the broader circuit.

    • Raunak Basu
    • , Robert Gebauer
    •  & Hiroshi T. Ito

  • Article |

    Experiments in mice identify the medial septum as an extrahippocampal input region that is critical for social memory formation, and show that modulation of the medial septum by serotonin regulates the stability of social memories.

    • Xiaoting Wu
    • , Wade Morishita
    •  & Robert C. Malenka

  • Article |

    Cell-type-specific electrophysiological recording, fibre photometry and optogenetic manipulations in mice show that dopamine signals from the ventral tegmental area to the lateral entorhinal cortex have a key role in cue–reward associative learning.

    • Jason Y. Lee
    • , Heechul Jun
    •  & Kei M. Igarashi

  • Article |

    All odours elicit a unique pattern of neuronal activity in primary olfactory cortex but these patterns drift over time, posing a problem for the perceptual constancy of odours.

    • Carl E. Schoonover
    • , Sarah N. Ohashi
    •  & Andrew J. P. Fink

  • Article |

    Exposure to a novel experience can ‘reset’ connections between the hippocampus and prefrontal cortex in mice, allowing them to overcome an existing learned behaviour and to replace it with a new one.

    • Alan J. Park
    • , Alexander Z. Harris
    •  & Joshua A. Gordon

  • Article |

    A dopamine neuron that underpins transient forgetting in Drosophila is activated by the presentation of interfering stimuli immediately before memory retrieval, modulating this retrieval by stimulating a dopamine receptor in mushroom body neurons.

    • John Martin Sabandal
    • , Jacob A. Berry
    •  & Ronald L. Davis

  • Article |

    In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.

    • Paras S. Minhas
    • , Amira Latif-Hernandez
    •  & Katrin I. Andreasson

  • Article |

    The net PKA activities in each class of spiny projection neuron in the nucleus accumbens of the mouse are dichotomously modulated by asynchronous positive and negative dopamine signals during different phases of learning.

    • Suk Joon Lee
    • , Bart Lodder
    •  & Bernardo L. Sabatini

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