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Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory
Spatial and single-cell transcriptomic analyses of the mouse basolateral amygdala reveal transcriptomic signatures, spatial resolution and interactions of cells that constitute the memory engram, including crucial neuron–astrocyte interactions.
- Wenfei Sun
- , Zhihui Liu
- & Stephen R. Quake
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Article
| Open Access
Psychedelics reopen the social reward learning critical period
Behavioural electrophysiological and transcriptomic studies in mice show that psychedelic drugs reopen the social reward learning critical period and suggest that this involves reorganization of the extracellular matrix.
- Romain Nardou
- , Edward Sawyer
- & Gül Dölen
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Prefrontal feature representations drive memory recall
Longitudinal imaging and functional perturbations during behaviour identified a brain region that represents constituent features of a contextual memory and enables feature-mediated memory recall.
- Nakul Yadav
- , Chelsea Noble
- & Priyamvada Rajasethupathy
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Cognitive control persistently enhances hippocampal information processing
Studies in mice show that cognitive control training rapidly improves brain circuit function and enhances subsequent learning, which both persist for months.
- Ain Chung
- , Claudia Jou
- & André A. Fenton
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Article
| Open Access
Mouse prefrontal cortex represents learned rules for categorization
Neurons in the mouse medial prefrontal cortex acquire category-selective responses with learning.
- Sandra Reinert
- , Mark Hübener
- & Pieter M. Goltstein
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Dopamine-based mechanism for transient forgetting
A dopamine neuron that underpins transient forgetting in Drosophila is activated by the presentation of interfering stimuli immediately before memory retrieval, modulating this retrieval by stimulating a dopamine receptor in mushroom body neurons.
- John Martin Sabandal
- , Jacob A. Berry
- & Ronald L. Davis
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Restoring metabolism of myeloid cells reverses cognitive decline in ageing
In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.
- Paras S. Minhas
- , Amira Latif-Hernandez
- & Katrin I. Andreasson
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Persistent transcriptional programmes are associated with remote memory
The authors identify long-lasting transcriptional programmes in neurons and glia that are associated with the storage of a remote memory.
- Michelle B. Chen
- , Xian Jiang
- & Thomas C. Südhof
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Memory failure predicted by attention lapsing and media multitasking
Lapses in attention before remembering partially account for why we remember or forget in the moment, why some individuals remember better than others, and why heavier media multitasking is related to worse memory.
- Kevin P. Madore
- , Anna M. Khazenzon
- & Anthony D. Wagner
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eIF2α controls memory consolidation via excitatory and somatostatin neurons
Stimulation of de novo protein synthesis in both excitatory and inhibitory, somatostatin-expressing neurons in the mouse hippocampus enhances memory consolidation.
- Vijendra Sharma
- , Rapita Sood
- & Nahum Sonenberg
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Parallel emergence of stable and dynamic memory engrams in the hippocampus
Imaging of hippocampal neuron activity in mice performing a memory task across several days identifies both stable and dynamic memory engrams.
- Thomas Hainmueller
- & Marlene Bartos
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Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors
Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.
- A. C. Penn
- , C. L. Zhang
- & D. Choquet
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Neural ensemble dynamics underlying a long-term associative memory
Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.
- Benjamin F. Grewe
- , Jan Gründemann
- & Mark J. Schnitzer
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Calcium transient prevalence across the dendritic arbour predicts place field properties
In vivo evidence for the existence of regenerative dendritic events in place cell dendrites of awake, behaving mice suggests an active role for dendritic spikes in building the representation of space in the hippocampus.
- Mark E. J. Sheffield
- & Daniel A. Dombeck
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Temporal multiplexing of perception and memory codes in IT cortex
Enzyme can strengthen memories