Hippocampus articles within Nature

Featured

  • Article |

    Using a Bayesian learning approach, a study tracks the spatial representations by individual hippocampal cells over time in freely moving rats, and provides insights into how ensemble patterns form and reconfigure during sleep.

    • Kourosh Maboudi
    • , Bapun Giri
    •  & Kamran Diba

  • Article
    | Open Access

    Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage repair, results in their recruitment to memory circuits.

    • Vladimir Jovasevic
    • , Elizabeth M. Wood
    •  & Jelena Radulovic

  • Article
    | Open Access

    In bats engaged in spontaneous collective spatial behaviour, a robust spatial structure emerges at the group level whereby behaviour is anchored to specific locations, movement patterns and individual social preferences, and many hippocampal neurons are tuned to key features of group dynamics.

    • Angelo Forli
    •  & Michael M. Yartsev

  • Article
    | Open Access

    Experiments in rats show that spatial representations in the hippocampus are closely coordinated with the forelimb stepping cycle, particularly when spatial decisions are approaching, and provide insight into how this synchronization supports information processing.

    • Abhilasha Joshi
    • , Eric L. Denovellis
    •  & Loren M. Frank

  • Article
    | Open Access

    Analysis of the activity of CA1 cells in mice performing a learning task shows that the entorhinal cortex signals behavioural timescale synaptic plasticity to generate learning-related changes in the hippocampus.

    • Christine Grienberger
    •  & Jeffrey C. Magee

  • Article
    | Open Access

    During rapid behavioural switches in flying bats, hippocampal neurons can rapidly switch their core computation to represent the relevant behavioural variables, supporting behavioural flexibility.

    • Ayelet Sarel
    • , Shaked Palgi
    •  & Nachum Ulanovsky

  • Article |

    A molecular mechanism involving CCR5 and CCL5 determines the temporal window in which a memory can be linked with subsequent memories, and in aged mice an increase in CCR5 is associated with defects in memory linking.

    • Yang Shen
    • , Miou Zhou
    •  & Alcino J. Silva

  • Article |

    The hippocampal code in freely flying bats is highly stable over days and across contexts if behaviour is taken into account.

    • William A. Liberti III
    • , Tobias A. Schmid
    •  & Michael M. Yartsev

  • Article |

    In memory consolidation, the hippocampus has a unique way to preferentially amplify behaviour-relevant information that entails ‘replaying’ this information during periods of rest.

    • Satoshi Terada
    • , Tristan Geiller
    •  & Attila Losonczy

  • Article |

    Single-cell tracing and optogenetics manipulation in mice are used to show how spatial tuning of individual pyramidal cells in CA1 can propagate to and be amplified by their local subnetwork of neurons.

    • Tristan Geiller
    • , Sadra Sadeh
    •  & Attila Losonczy

  • Article |

    Experiments in mice identify the medial septum as an extrahippocampal input region that is critical for social memory formation, and show that modulation of the medial septum by serotonin regulates the stability of social memories.

    • Xiaoting Wu
    • , Wade Morishita
    •  & Robert C. Malenka

  • Article |

    Cell-type-specific electrophysiological recording, fibre photometry and optogenetic manipulations in mice show that dopamine signals from the ventral tegmental area to the lateral entorhinal cortex have a key role in cue–reward associative learning.

    • Jason Y. Lee
    • , Heechul Jun
    •  & Kei M. Igarashi

  • Article |

    Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the roles of FOS and SCG2 in neural plasticity and consolidation of memories.

    • Ee-Lynn Yap
    • , Noah L. Pettit
    •  & Michael E. Greenberg

  • Article |

    The supramammillary nucleus in the hypothalamus acts as a novelty hub that selectively directs different types of novelty signals to different subregions of the hippocampus and flexibly modulates the encoding of memory.

    • Shuo Chen
    • , Linmeng He
    •  & Thomas J. McHugh

  • Article |

    Social memory is consolidated in the brain through the reactivation of neuronal firing by sharp-wave ripples in the CA2 region of the hippocampus, in a similar way to the consolidation of spatial memory.

    • Azahara Oliva
    • , Antonio Fernández-Ruiz
    •  & Steven A. Siegelbaum

  • Letter |

    Cells in the mouse medial entorhinal cortex that fire when mice are at a specific distance and direction from a stationary object suggest that vector coding is important for rodent navigation.

    • Øyvind Arne Høydal
    • , Emilie Ranheim Skytøen
    •  & Edvard I. Moser

  • Letter |

    Evidence from hippocampal place cells shows that path-integration gain, previously thought to be a constant factor in the computation of location, is flexible and can be rapidly fine-tuned.

    • Ravikrishnan P. Jayakumar
    • , Manu S. Madhav
    •  & James J. Knierim

  • Article |

    Temporal information that is useful for episodic memory is encoded across a wide range of timescales in the lateral entorhinal cortex, arising inherently from its representation of ongoing experience.

    • Albert Tsao
    • , Jørgen Sugar
    •  & Edvard I. Moser

  • Article |

    Projections from the locus coeruleus, an area typically defined by noradrenergic signalling, to the hippocampus drive novelty-based memory enhancement through possible co-release of dopamine.

    • Tomonori Takeuchi
    • , Adrian J. Duszkiewicz
    •  & Richard G. M. Morris

  • Letter |

    People infected with West Nile virus often experience cognitive side effects including memory loss through unknown mechanisms; mice and humans infected with the virus experience a loss in hippocampal presynaptic terminals, which can be reversed by disrupting complement or microglia in mice.

    • Michael J. Vasek
    • , Charise Garber
    •  & Robyn S. Klein

  • Letter |

    A similar neural ensemble participates in the encoding of two distinct memories, resulting in the recall of one memory increasing the likelihood of recalling the other, but only if those memories occur very closely in time—within a day rather than across a week.

    • Denise J. Cai
    • , Daniel Aharoni
    •  & Alcino J. Silva

  • Letter |

    A new microendoscopic method reveals that hippocampal dendritic spines in the CA1 region undergo a complete turnover in less than six weeks in adult mice; this contrasts with the much greater stability of synapses in the neocortex and provides a physical basis for the fact that episodic memories are only retained by the mouse hippocampus for a few weeks.

    • Alessio Attardo
    • , James E. Fitzgerald
    •  & Mark J. Schnitzer

  • Article |

    Spatial working memory is known to involve the prefrontal cortex and the hippocampus, but the specificities of the connection have been unclear; now, a direct path between these two areas is defined that is necessary for the encoding of spatial cues in mice, but is not required for the maintenance or retrieval of these cues.

    • Timothy Spellman
    • , Mattia Rigotti
    •  & Joshua A. Gordon

  • Letter |

    An optogenetic approach in mice was used to investigate the neural mechanisms underlying memory valence association; dentate gyrus, but not amygdala, memory engram cells exhibit plasticity in valence associations, suggesting that emotional memory associations can be changed at the circuit level.

    • Roger L. Redondo
    • , Joshua Kim
    •  & Susumu Tonegawa

  • Letter |

    Simultaneous recordings from hippocampus and entorhinal cortex in rats show that as the animals learn odour guidance cues during their exploration of two-dimensional space in the laboratory, ensembles of coherently firing neurons emerge in both locations, with cortical–hippocampal oscillatory coupling occurring in a specific range of the beta-gamma frequency band.

    • Kei M. Igarashi
    • , Li Lu
    •  & Edvard I. Moser

  • Letter |

    CA2 neuron inactivation leads to a severe deficit in social memory, while having little effect on other well-known hippocampal functions such as contextual or spatial memory.

    • Frederick L. Hitti
    •  & Steven A. Siegelbaum

  • Article |

    It is known that compressed sequences of hippocampal place cells can ‘replay’ previous navigational trajectories in linearly constrained mazes; here, rat place-cell sequences representing two-dimensional spatial trajectories were observed before navigational decisions, and predicted the immediate navigational path.

    • Brad E. Pfeiffer
    •  & David J. Foster

  • Letter |

    It was proposed that protein kinase M-ζ (PKM-ζ) is a key factor in long-term potentiation (LTP) and memory maintenance on the basis of the disruption of LTP and memory by inhibitors of PKM-ζ; however, here mice that do not express PKM-ζ are shown to have normal LTP and memory, thus casting doubts on a critical role for PKM-ζ in these processes.

    • Lenora J. Volk
    • , Julia L. Bachman
    •  & Richard L. Huganir

  • Article |

    Simultaneous electrophysiological recordings in hippocampus and neural-activity-triggered whole-brain imaging in the monkey show that most of the cerebral cortex is activated during the fast hippocampal oscillations (ripples), whereas most diencephalic, midbrain and brainstem regions are inhibited; this may function to optimize information transfer from hippocampus to cortex during off-line memory consolidation.

    • N. K. Logothetis
    • , O. Eschenko
    •  & A. Oeltermann

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