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Population dynamics of head-direction neurons during drift and reorientation
Mice maintain the memory of previous associations between head direction neurons and allocentric cues and this influences the internal head direction representation.
- Zaki Ajabi
- , Alexandra T. Keinath
- & Mark P. Brandon
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A cortico-collicular circuit for orienting to shelter during escape
The retrosplenial cortex and superior colliculus of mouse form a neural circuit that specifically encodes shelter location, facilitating rapid escape from predatory threats.
- Dario Campagner
- , Ruben Vale
- & Tiago Branco
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Article
| Open Access
Dopamine promotes head direction plasticity during orienting movements
A study demonstrates that plasticity in the head direction system in Drosophila is modulated by dopamine, which increases learning when reorienting movements are bringing in new spatial information.
- Yvette E. Fisher
- , Michael Marquis
- & Rachel I. Wilson
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Article
| Open Access
Natural switches in behaviour rapidly modulate hippocampal coding
During rapid behavioural switches in flying bats, hippocampal neurons can rapidly switch their core computation to represent the relevant behavioural variables, supporting behavioural flexibility.
- Ayelet Sarel
- , Shaked Palgi
- & Nachum Ulanovsky
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Article
| Open Access
Hippocampal place cells have goal-oriented vector fields during navigation
A vector-based model for flexible navigation in the hippocampus allows animals to optimally navigate to any location in their environment.
- Jake Ormond
- & John O’Keefe
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Cognitive control persistently enhances hippocampal information processing
Studies in mice show that cognitive control training rapidly improves brain circuit function and enhances subsequent learning, which both persist for months.
- Ain Chung
- , Claudia Jou
- & André A. Fenton
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Article
| Open Access
The orbitofrontal cortex maps future navigational goals
Dedicated cells in the hippocampus and entorhinal cortex map an animal s instantaneous position in space; by contrast, its future goal location is represented in the orbitofrontal cortex, a structure within the broader circuit.
- Raunak Basu
- , Robert Gebauer
- & Hiroshi T. Ito
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Linking hippocampal multiplexed tuning, Hebbian plasticity and navigation
Episodic memory and allocentric spatial navigation are interwoven in the activity of hippocampal neuron ensembles via Hebbian plasticity, which allows rats to encode journey-specific episodes.
- Jason J. Moore
- , Jesse D. Cushman
- & Mayank R. Mehta
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Locally ordered representation of 3D space in the entorhinal cortex
Recordings from the brains of freely flying bats show that grid cells that represent 3D space have multiple firing fields and are organized with local rather than global order.
- Gily Ginosar
- , Johnatan Aljadeff
- & Nachum Ulanovsky
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Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome
In a mouse model of Rett syndrome, intensive training during the presymptomatic period markedly improves the performance of motor and memory tasks and delays the onset of symptoms, providing a rationale for the genetic screening of newborn babies.
- Nathan P. Achilly
- , Wei Wang
- & Huda Y. Zoghbi
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Boundary-anchored neural mechanisms of location-encoding for self and others
In real-world spatial navigation and observation tasks, oscillatory activity in the human brain encodes representations of self and others, with oscillatory power increasing at locations near the boundaries of the room.
- Matthias Stangl
- , Uros Topalovic
- & Nanthia Suthana
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Recalibration of path integration in hippocampal place cells
Evidence from hippocampal place cells shows that path-integration gain, previously thought to be a constant factor in the computation of location, is flexible and can be rapidly fine-tuned.
- Ravikrishnan P. Jayakumar
- , Manu S. Madhav
- & James J. Knierim
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Coherent encoding of subjective spatial position in visual cortex and hippocampus
When running through a virtual reality corridor, a mouse’s position is represented in both the hippocampus (as expected) and the primary visual cortex, for places that are visually identical.
- Aman B. Saleem
- , E. Mika Diamanti
- & Matteo Carandini
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Parallel emergence of stable and dynamic memory engrams in the hippocampus
Imaging of hippocampal neuron activity in mice performing a memory task across several days identifies both stable and dynamic memory engrams.
- Thomas Hainmueller
- & Marlene Bartos
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The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation
A newly designed honeycomb maze presents several advantages over current spatial navigation assays that include greater control over the rat’s choices throughout the task and the collection of electrophysiological data during navigation.
- Ruth A. Wood
- , Marius Bauza
- & John O’Keefe
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Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit
Cells in the hippocampal–entorhinal circuit, which fire in response to navigational variables such as location or speed, are shown also to encode continuous, task-relevant but non-spatial variables such as sound frequency.
- Dmitriy Aronov
- , Rhino Nevers
- & David W. Tank
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Three-dimensional head-direction coding in the bat brain
A study of freely moving bats provides new insights into how the brain encodes a three-dimensional neural compass; neurons were identified encoding the three Euler rotation angles of the head (azimuth, pitch, and roll) and recordings from these head-direction cells revealed a toroidal model of spatial orientation mapped out by cells tuned to two circular variables (azimuth × pitch).
- Arseny Finkelstein
- , Dori Derdikman
- & Nachum Ulanovsky
Dynamic synchronization between hippocampal representations and stepping