Molecular Diagnostics
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Open Access
Featured
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Genetics and Genomics
| Open AccessBasal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection
- C-M Chu
- , C-C Lin
- & Y-F Liaw
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Molecular Diagnostics
| Open AccessPotential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway
- H Joshi
- , G Bhanot
- & V Kristensen
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Genetics and Genomics
| Open AccessExon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome
- A Schramm
- , B Schowe
- & J H Schulte
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Genetics and Genomics
| Open AccessThe FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma
- M Dibb
- , N Han
- & A D Sharrocks
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Molecular Diagnostics
| Open AccessMicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer
- S Ali
- , H Saleh
- & P A Philip
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Molecular Diagnostics
| Open AccessTissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
- L Lo
- , H Valentine
- & Y Ang
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Molecular Diagnostics
| Open AccessThe utility of molecular diagnostics to predict recurrence of head and neck carcinoma
- C Pena Murillo
- , X Huang
- & M Partridge
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Molecular Diagnostics
| Open AccessExpression of oestrogen receptor β and prognosis of colorectal cancer
- A Rudolph
- , C Toth
- & J Chang-Claude
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Molecular Diagnostics
| Open AccessExpression and prognostic significance of Src family members in renal clear cell carcinoma
- T Qayyum
- , P A McArdle
- & J Edwards
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Clinical Study
| Open AccessKRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer
- U Malapelle
- , C Carlomagno
- & G Troncone
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Genetics and Genomics
| Open AccessSite-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBPδ) CpG island in breast cancer is associated with metastatic relapse
- C Palmieri
- , M Monteverde
- & T Crook
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Clinical Study
| Open AccessRelationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial
- I Sestak
- , R Kealy
- & J Cuzick
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Molecular Diagnostics
| Open AccessMixed lineage leukaemia-4 regulates cell-cycle progression and cell viability and its depletion suppresses growth of xenografted tumour in vivo
- K I Ansari
- , S Kasiri
- & S S Mandal
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Molecular Diagnostics
| Open AccessNT5E CpG island methylation is a favourable breast cancer biomarker
- C Lo Nigro
- , M Monteverde
- & T Crook
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Genetics and Genomics
| Open AccessSplice variant PRKC-ζ-PrC is a novel biomarker of human prostate cancer
- S Yao
- , S J Ireland
- & C S Foster
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Molecular Diagnostics
| Open AccessKRAS mutations in primary tumours and post-FOLFOX metastatic lesions in cases of colorectal cancer
- Y Kawamoto
- , K Tsuchihara
- & A Ohtsu
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Molecular Diagnostics
| Open AccessExpression of MAGE-A3, NY-ESO-1, LAGE-1 and PRAME in urothelial carcinoma
- L Dyrskjøt
- , K Zieger
- & T F Ørntoft
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Genetics and Genomics
| Open AccessAssociation of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
- A Jakubowska
- , D Rozkrut
- & J Lubinski
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Molecular Diagnostics
| Open Accessc-Myc and EBV–LMP1: two opposing regulators of the HLA class I antigen presentation machinery in epithelial cells
- C S Tudor
- , C W Dawson
- & M Buettner
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Clinical Study
| Open AccessLong-term results of screening with magnetic resonance imaging in women with BRCA mutations
- K Passaperuma
- , E Warner
- & S A Narod
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Translational Therapeutics
| Open AccessIntrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells
- T Troiani
- , L Vecchione
- & F Ciardiello
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Molecular Diagnostics
| Open AccessDownregulation of membrane complement inhibitors CD55 and CD59 by siRNA sensitises uterine serous carcinoma overexpressing Her2/neu to complement and antibody-dependent cell cytotoxicity in vitro: implications for trastuzumab-based immunotherapy
- S Bellone
- , D Roque
- & A D Santin
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Genetics and Genomics
| Open AccessPPARγ agonists regulate the expression of stemness and differentiation genes in brain tumour stem cells
- E Pestereva
- , S Kanakasabai
- & J J Bright
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Genetics and Genomics
| Open AccessGermline BRCA1 mutations increase prostate cancer risk
- D Leongamornlert
- , N Mahmud
- & Z Kote-Jarai
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Molecular Diagnostics
| Open AccessExpression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach
- M Yoshii
- , H Tanaka
- & K Hirakawa
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Translational Therapeutics
| Open AccessThe cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction
- G Descamps
- , P Gomez-Bougie
- & M Amiot
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Translational Therapeutics
| Open AccessNegative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
- L G Feun
- , A Marini
- & N Savaraj
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Molecular Diagnostics
| Open AccessMitochondrial D310 mutations in the early development of breast cancer
- C Xu
- , D Tran-Thanh
- & S J Done
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Short Communication
| Open AccessMMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
- A M J Langers
- , H W Verspaget
- & C F M Sier
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Molecular Diagnostics
| Open AccessExpression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer
- J Ohotski
- , J S Long
- & J Edwards
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Translational Therapeutics
| Open AccessImpact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells
- U Stein
- , C Fleuter
- & W Walther
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Molecular Diagnostics
| Open AccessImpact of genomic stability on protein expression in endometrioid endometrial cancer
- M I Lomnytska
- , S Becker
- & G Auer
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Clinical Study
| Open AccessMulticentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer
- J Harder
- , G Ihorst
- & M Geissler
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Genetics and Genomics
| Open AccessDetection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria
- E A Roundhill
- & S A Burchill
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Molecular Diagnostics
| Open AccessClinical significance of CD151 overexpression in subtypes of invasive breast cancer
- M J Kwon
- , S Park
- & Y-L Choi
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Molecular Diagnostics
| Open AccessFGFR2 gene amplification and clinicopathological features in gastric cancer
- K Matsumoto
- , T Arao
- & Y Yamada
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Genetics and Genomics
| Open AccessRenal cancer and pneumothorax risk in Birt–Hogg–Dubé syndrome; an analysis of 115 FLCN mutation carriers from 35 BHD families
- A C Houweling
- , L M Gijezen
- & F H Menko
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Genetics and Genomics
| Open AccessPTEN and PIK3CA gene copy numbers and poor outcomes in non-small cell lung cancer patients with gefitinib therapy
- M J Fidler
- , L E Morrison
- & P D Bonomi
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Genetics and Genomics
| Open AccessDistinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia
- H-A Hou
- , Y-Y Kuo
- & H-F Tien
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Genetics and Genomics
| Open AccessSegmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)
- G Schleiermacher
- , J Michon
- & J Couturier
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Genetics and Genomics
| Open AccessEvaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk
- K N Stevens
- , M Garcia-Closas
- & D F Easton
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Molecular Diagnostics
| Open AccessHost-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production
- H Fukuda
- , S Mochizuki
- & Y Okada
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Translational Therapeutics
| Open AccessImmunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
- J Šímová
- , V Polláková
- & M Reiniš
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Genetics and Genomics
| Open AccessBRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
- Z Kote-Jarai
- , D Leongamornlert
- & R Eeles
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Translational Therapeutics
| Open AccessOverexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma
- M Nagata
- , H Nakayama
- & M Shinohara
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Molecular Diagnostics
| Open AccessUpregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer
- K Armstrong
- , I Ahmad
- & H Y Leung
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Genetics and Genomics
| Open AccessIs there a genetic cause for cancer cachexia? – a clinical validation study in 1797 patients
- T S Solheim
- , P M Fayers
- & S Kaasa
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Molecular Diagnostics
| Open AccessGSTPi-positive tumour microenvironment-associated fibroblasts are significantly associated with GSTPi-negative cancer cells in paired cases of primary invasive breast cancer and axillary lymph node metastases
- B Chaiwun
- , N Sukhamwang
- & S A Imam
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Translational Therapeutics
| Open AccessRapid non-genomic signalling by 17β-oestradiol through c-Src involves mTOR-dependent expression of HIF-1α in breast cancer cells
- S Sudhagar
- , S Sathya
- & B S Lakshmi
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