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Original Article
| Open AccessAll-trans retinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells
- XiangZhen Liu
- , Juan Chen
- & Jiang Zhu
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Original Article
| Open AccessCryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation
- Liang Lu
- , Sulin Zhang
- & Xiaoyan Shen
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Original Article
| Open AccessMK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway
- Ru-Fang Xiang
- , Yan Wang
- & Hua Yan
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Original Article
| Open AccessHalofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer
- Guo-Qing Chen
- , Rui-Hong Gong
- & Zhao-Xiang Bian
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Original Article
| Open AccessPLSCR1/IP3R1/Ca2+ axis contributes to differentiation of primary AML cells induced by wogonoside
- Hui Li
- , Jingyan Xu
- & Hui Hui
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Original Article
| Open AccessDiptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells
- Jian Gao
- , Minmin Fan
- & Qiang Xu
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Original Article
| Open AccessTargeted apoptosis in ovarian cancer cells through mitochondrial dysfunction in response to Sambucus nigra agglutinin
- Shreya Roy Chowdhury
- , Upasana Ray
- & Sib S Roy
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Original Article
| Open AccessWithaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences
- Yue Yu
- , Shashank P Katiyar
- & Renu Wadhwa
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Original Article
| Open AccessmiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice
- Pedro M Rodrigues
- , Marta B Afonso
- & Rui E Castro
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Original Article
| Open AccessInduction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
- Yi Yang
- , Sicong Chen
- & Lihui Zhang
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Original Article
| Open AccessMadecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway
- Xiaotian Xu
- , Yuhui Wang
- & Yue Dai
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Original Article
| Open AccessMitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells
- Farhan Basit
- , Lisanne MPE van Oppen
- & Werner JH Koopman
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Original Article
| Open AccessFunctional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death
- Saskia Klutzny
- , Ralf Lesche
- & Patrick Steigemann
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Original Article
| Open AccessHydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway
- Shanshan S Wang
- , Yuhan H Chen
- & Huiguo G Ding
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Original Article
| Open AccessTargeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs
- Jiancheng Zhou
- , Eun-Jin Yun
- & Jer-Tsong Hsieh
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Original Article
| Open AccessGanetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner
- Evguenia M Alexandrova
- , Sulan Xu
- & Ute M Moll
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Original Article
| Open AccessCystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer
- Byung Moo Oh
- , Seon-Jin Lee
- & Hee Gu Lee
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Original Article
| Open AccessDigoxin-induced retinal degeneration depends on rhodopsin
- Britta Landfried
- , Marijana Samardzija
- & Christian Grimm
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Original Article
| Open AccessSimvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth
- Juan Li
- , Jie Liu
- & Peijun Liu
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Original Article
| Open AccessGeranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation
- Sherry S Agabiti
- , Jin Li
- & Andrew J Wiemer
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Original Article
| Open AccessBH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides
- Pawel E Ferdek
- , Monika A Jakubowska
- & Ole H Petersen
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Original Article
| Open AccessGinsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1
- Yi-Lin Yang
- , Jia Li
- & Lian-Wen Qi
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Original Article
| Open AccessOridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells
- Zhuo Yao
- , Fuhua Xie
- & Liang-Hu Qu
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Original Article
| Open AccessRapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease
- Yunlong Zhang
- , Xiaoliang He
- & Shaogang Qu
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Original Article
| Open AccessPhoto-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis
- Ning Yang
- , Michael Weinfeld
- & Ing Swie Goping
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Original Article
| Open AccessBerbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy
- Yanjun Zheng
- , Shanshan Gu
- & Huang-Tian Yang
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Original Article
| Open AccessColon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death
- Jianzhong Qin
- , Nicholas Kunda
- & Ajay V Maker
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Original Article
| Open AccessAugmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis
- Liane Jennifer Bailey
- , Sruthi Alahari
- & Isabella Caniggia
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Original Article
| Open AccessNon-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection
- Shereen Nizari
- , Li Guo
- & M Francesca Cordeiro
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Original Article
| Open AccessLarge-scale pharmacological profiling of 3D tumor models of cancer cells
- Lesley A Mathews Griner
- , Xiaohu Zhang
- & Marc Ferrer
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Original Article
| Open AccessSystemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules
- Shen Dai
- , Bo Wang
- & Lining Zhang
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Original Article
| Open AccessAnti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
- Vibeke Andresen
- , Bjarte S Erikstein
- & Bjørn T Gjertsen
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Original Article
| Open AccessA mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
- Nicole A Seebacher
- , Des R Richardson
- & Patric J Jansson
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Original Article
| Open AccessTherapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models
- Stuart A Lipton
- , Tayebeh Rezaie
- & Nobuki Nakanishi
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Original Article
| Open AccessSTAT6 deficiency ameliorates Graves’ disease severity by suppressing thyroid epithelial cell hyperplasia
- Xuechao Jiang
- , Bingbing Zha
- & Yiwei Chu
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Review
| Open AccessThe control of male fertility by spermatid-specific factors: searching for contraceptive targets from spermatozoon’s head to tail
- Su-Ren Chen
- , Aalia Batool
- & Yi-Xun Liu
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Original Article
| Open AccessmiR-203 inhibits the traumatic heterotopic ossification by targeting Runx2
- Bing Tu
- , Shen Liu
- & Cunyi Fan
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Original Article
| Open AccessDesferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1
- Hui Kang
- , Yufei Yan
- & Lianfu Deng
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Original Article
| Open AccessMelatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway
- Yun-Xin Lu
- , Dong-Liang Chen
- & Rui-Hua Xu
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Original Article
| Open AccessMetformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
- Deheng Chen
- , Dongdong Xia
- & Naifeng Tian
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Original Article
| Open AccessEffects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance
- Yvonne Voges
- , Martin Michaelis
- & Jindrich Cinatl
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Original Article
| Open AccessRETRACTED ARTICLE: Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
- Tao Zhang
- , Suoyuan Li
- & Zhengdong Cai
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News and Commentary
| Open AccessBivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling
- Stephen M Condon
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Original Article
| Open AccessPharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis
- Izhar Livne-Bar
- , Susy Lam
- & Jeremy M Sivak
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Original Article
| Open AccessInhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype
- Paola Infante
- , Romina Alfonsi
- & Lucia Di Marcotullio
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Original Article
| Open AccessKinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-κB signaling in macrophages and protecting endothelial cells
- Qiao Han
- , Wang Bing
- & Tang Ting-ting
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Original Article
| Open AccessGp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity
- J Wu
- , W Guo
- & Y-Z Zhu
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Original Article
| Open AccessGinsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation
- Lei Chen
- , Yue Meng
- & Yifa Zhou
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Original Article
| Open AccessInhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152
- A Tchoghandjian
- , A Soubéran
- & D Figarella-Branger
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