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Targeting EMT using low-dose Teniposide by downregulating ZEB2-driven activation of RNA polymerase I in breast cancer
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Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression
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Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control
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BACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia
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The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment
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Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma
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Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells
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Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
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Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1
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Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I
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Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
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Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
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GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL
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SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
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Activation of FXR and inhibition of EZH2 synergistically inhibit colorectal cancer through cooperatively accelerating FXR nuclear location and upregulating CDX2 expression
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Genome-wide screening in the haploid system reveals Slc25a43 as a target gene of oxidative toxicity
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Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction
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Identification of Nanog as a novel inhibitor of Rad51
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Inhibition of mitoNEET attenuates LPS-induced inflammation and oxidative stress
- Seunghee Lee
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Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma
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PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer
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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells
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Monocytes secrete CXCL7 to promote breast cancer progression
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Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level
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Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor
- Tom Delanghe
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Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells
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High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis
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Directly targeting c-Myc contributes to the anti-multiple myeloma effect of anlotinib
- Yang Cao
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Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway
- Keting Bao
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Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
- Konstantinos V. Floros
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CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9
- Yanli Zhang
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Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore
- Anees Rahman Cheratta
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KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer
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Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma
- Jing Liu
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Dual inhibition of HDAC and tyrosine kinase signaling pathways with CUDC-907 attenuates TGFβ1 induced lung and tumor fibrosis
- Wentian Zhang
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Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells
- Shiqi She
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Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS
- In Jun Yeo
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LXA4-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling
- Hyunjung Kim
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Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells
- ZhaoMin Lin
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Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis
- Zhong Chen
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PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2
- Nan Huang
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Dual role of Ca2+-activated Cl− channel transmembrane member 16A in lipopolysaccharide-induced intestinal epithelial barrier dysfunction in vitro
- Jingru Sui
- , Chi Zhang
- & Dapeng Chen
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A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries
- Samuel Domínguez-García
- , Noelia Geribaldi-Doldán
- & Carmen Castro
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MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer
- Lorenzo Stramucci
- , Angelina Pranteda
- & Gianluca Bossi
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PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis
- Chengcheng Shi
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Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer