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Article
| Open AccessAntibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice
- Maria Rosito
- , Javeria Maqbool
- & Cristina Limatola
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Review Article
| Open AccessMechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases
- Lian Wang
- , Yanghui Zhu
- & Gu He
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Article
| Open AccessSpecific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG
- Jingwen Deng
- , Shaoxia Liao
- & Honghe Zhang
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Review Article
| Open AccessEmerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
- Jinghan Li
- , Sujuan Zheng
- & Ke Tan
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Article
| Open AccessIntracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells
- Flore Sneyers
- , Martijn Kerkhofs
- & Geert Bultynck
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Article
| Open AccessUfmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress
- Ziming Mao
- , Xiaowen Ma
- & Fengling Chen
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Article
| Open AccessTHOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification
- Tao Yu
- , Qi Zhang
- & Kai-Hua Lu
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Article
| Open AccessApoptotic exosome-like vesicles transfer specific and functional mRNAs to endothelial cells by phosphatidylserine-dependent macropinocytosis
- Alexandre Brodeur
- , Francis Migneault
- & Marie-Josée Hébert
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Article
| Open AccessTargeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid
- Xian-Yang Qin
- , Yutaka Furutani
- & Soichi Kojima
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Article
| Open AccessMolecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules
- Thamara Nishida Xavier da Silva
- , Clemens Schulte
- & José Pedro Friedmann Angeli
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Article
| Open AccessDasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1
- Xinning Liu
- , Yanan Jiang
- & Zhiping Guo
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Article
| Open AccessNatural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo
- Yinsong Zhu
- , Peibin Yue
- & James Turkson
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Article
| Open AccessHDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation
- Meng Li
- , Mingying Li
- & Chunyan Ji
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Article
| Open AccessCOX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism
- Yetong Feng
- , Jiayi Xu
- & Pengfei Liu
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Article
| Open AccessOxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility
- Yingying Ma
- , Meiqi Yi
- & Haiteng Deng
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Article
| Open AccessThe mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism
- Fabian Stuhldreier
- , Laura Schmitt
- & Sebastian Wesselborg
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Article
| Open AccessAsparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response
In the Wnt pathway, phosphorylation of GSK3β(S9) is very important to stabilize β-catenin complex, ASNS can upregulate phosphorylation of AKT on Ser473, then promote GSK3β phosphorylation on Ser9 to stabilize β-catenin complex. When Wnt pathway is activated, ASNS elevates p-DRP1(637) and decreases p-DRP1(616) to suppress mitochondrial fission.
- Dong-Jing Cai
- , Zi-Yu Zhang
- & Min Li
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Article
| Open AccessDysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming
- Lu Qiu
- , Qiufang Yang
- & Yuanming Qi
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Article
| Open AccessGenome-wide screening in the haploid system reveals Slc25a43 as a target gene of oxidative toxicity
- Jinxin Zhang
- , Yiding Zhao
- & Ling Shuai
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Article
| Open AccessLoss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation
- Artin Soroosh
- , Kai Fang
- & Carl R. Rankin
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Article
| Open AccessIdentification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases
- Paula M. Soriano-Teruel
- , Guillermo García‑Laínez
- & Mar Orzáez
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Article
| Open AccessFDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair
- Shu-Ping Wang
- , Shi-Qi Wu
- & Yun-Gen Xu
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Article
| Open AccessNicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells
- Ya Meng
- , Chengcheng Song
- & Guokai Chen
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Article
| Open AccessInhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
- Tatiana A. Giovannucci
- , Florian A. Salomons
- & Nico P. Dantuma
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Article
| Open AccessPRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma
- Tian Xia
- , Ming Liu
- & Bing Chen
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Article
| Open AccessAntioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor
- Tom Delanghe
- , Jon Huyghe
- & Mathieu J. M. Bertrand
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Article
| Open AccessSorafenib fails to trigger ferroptosis across a wide range of cancer cell lines
- Jiashuo Zheng
- , Mami Sato
- & Marcus Conrad
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Article
| Open AccessA novel BRD4 inhibitor suppresses osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways
- Ying Liu
- , Wenjie Liu
- & Shipeng He
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Article
| Open AccessFangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway
- Keting Bao
- , Yongyun Li
- & Jian Li
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Article
| Open AccessCeramides and sphingosine-1-phosphate mediate the distinct effects of M1/M2-macrophage infusion on liver recovery after hepatectomy
- Hang Sun
- , Shibo Sun
- & Kai Wang
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Article
| Open AccessMetabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers
- François-Xavier Danlos
- , Claudia Grajeda-Iglesias
- & Guido Kroemer
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Article
| Open AccessSIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation
- Zhiya Deng
- , Maomao Sun
- & Zhenhua Zeng
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Article
| Open AccessPeriod1 mediates rhythmic metabolism of toxins by interacting with CYP2E1
- Wenhao Ge
- , Tao Wang
- & Jianfa Zhang
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Article
| Open AccessGlucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment
- Rui Xu
- , Ming Wu
- & Fang Wang
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Article
| Open AccessDiscovery of a novel ferroptosis inducer-talaroconvolutin A—killing colorectal cancer cells in vitro and in vivo
- Yong Xia
- , Shuzhi Liu
- & Xiaolong Yang
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Article
| Open AccessHeme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron
- Nina Seiwert
- , Sabine Wecklein
- & Jörg Fahrer
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Article
| Open AccessCDK9 activity is critical for maintaining MDM4 overexpression in tumor cells
- Monika Štětková
- , Kateřina Growková
- & Stjepan Uldrijan
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Article
| Open AccessAcyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition
- Yunchang Liu
- , Liping Zeng
- & Hong Wang
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Article
| Open AccessDPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes
- Darren C. Johnson
- , Marian C. Okondo
- & Daniel A. Bachovchin
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Article
| Open AccessThe micropeptide LEMP plays an evolutionarily conserved role in myogenesis
- Lantian Wang
- , Jing Fan
- & Hong Cheng
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Article
| Open AccessWTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
- Teresa Maria Carusone
- , Giovanna Cardiero
- & Giuseppe Manco
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Article
| Open AccessThe heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism
- Shuangyan Ye
- , Pengfei Xu
- & Qiuzhen Liu
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Article
| Open AccessThe regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis
- Xiaoyuan Zhu
- , Xueping Wang
- & Yulin Zhao
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Article
| Open AccessPeroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus
- Dong Gil Lee
- , Min Kyoung Kam
- & Dong-Seok Lee
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Article
| Open Accessα-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux
Schematic diagram of the mechanisms whereby α-linolenic acid protects against endothelial dysfunction and hypertension.
- Guohua Li
- , Xinpei Wang
- & Jia Li
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Article
| Open AccessThe natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II
- Hye-Young Min
- , Hyun-Ji Jang
- & Ho-Young Lee
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Article
| Open AccessROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- Chuangyu Wen
- , Huihui Wang
- & Junsheng Peng
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Article
| Open AccessMatrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways
- Xi Zhang
- , Guoqing Hou
- & Xuan Cao
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Article
| Open AccessArtificial tethering of LC3 or p62 to organelles is not sufficient to trigger autophagy
- Friedemann Loos
- , Wei Xie
- & Guido Kroemer
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