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| Open AccessTNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME
- Hongkun Zhao
- , Yating Dai
- & Hua Li
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Article
| Open AccessDARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma
- Alexander Strubel
- , Philipp Münick
- & Volker Dötsch
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Article
| Open AccessMRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium
- Anurag Kumar Singh
- , Amrita Rai
- & Guido Posern
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Article
| Open AccessNitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
- Laura Ryder
- , Frederic Schrøder Arendrup
- & Simon Bekker-Jensen
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Article
| Open AccessA Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission
- Mai N. Nguyen
- , Dibyendu Chakraborty
- & Steven J. Pittler
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Article
| Open AccessThe ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma
- Kun Wang
- , Siyu Chen
- & Yijun Chen
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Article
| Open AccessTRAP1 S-nitrosylation as a model of population-shift mechanism to study the effects of nitric oxide on redox-sensitive oncoproteins
- Elena Papaleo
- , Matteo Tiberti
- & Giuseppe Filomeni
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Article
| Open AccessPRPF19 facilitates colorectal cancer liver metastasis through activation of the Src-YAP1 pathway via K63-linked ubiquitination of MYL9
- Rui Zhou
- , Jie Chen
- & Lin Qiu
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Review Article
| Open AccessTo be or not to be a fat burner, that is the question for cpt1c in cancer cells
- Rut Fadó
- , Sebastian Zagmutt
- & Núria Casals
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Article
| Open AccessCrocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I
- Hao Wu
- , Ying Li
- & Dan Ohtan Wang
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Article
| Open AccessIncreased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway
- Ting Lan
- , Ying Li
- & Lan Luo
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Article
| Open AccessHDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation
- Meng Li
- , Mingying Li
- & Chunyan Ji
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Article
| Open AccessTension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration
- Yunfeng Hu
- , Qiu Xie
- & Jun Guo
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Article
| Open AccessDominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
- Henning T. Langer
- , Agata A. Mossakowski
- & Keith Baar
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Article
| Open AccessThe deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
- Jin Li
- , Yibin Dai
- & Hongbing Jiang
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Article
| Open AccessOTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation
- Xing Liu
- , Hongyan Deng
- & Wuhan Xiao
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Article
| Open AccessDysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming
- Lu Qiu
- , Qiufang Yang
- & Yuanming Qi
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Article
| Open AccessEvolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
- Qiang Zhang
- , Dimitrios-Ilias Balourdas
- & Andreas C. Joerger
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Article
| Open AccessMolecular basis of apoptotic DNA fragmentation by DFF40
- Hyun Ji Ha
- & Hyun Ho Park
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Article
| Open AccessMethyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages
- Kai Ai
- , Jian Pan
- & Dongshan Zhang
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Article
| Open AccessHERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer
- Zhiyuan Zhang
- , Guodong He
- & Jianmin Xu
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Article
| Open AccessCPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency
- Fang E.
- , He Zhang
- & Xu Gao
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Article
| Open AccessInhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway
- Tongzhou Liang
- , Taiqiu Chen
- & Dongsheng Huang
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Article
| Open AccessInduced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting
- Jie Jin
- , Xianbin Meng
- & Haiteng Deng
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Article
| Open AccessEndoplasmic reticulum−mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells
- Camila Lopez-Crisosto
- , Alexis Díaz-Vegas
- & Sergio Lavandero
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Article
| Open AccessK63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR
- Pengshan Zhang
- , Zhe Zhang
- & Man Mohan
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Article
| Open AccessThe RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase
- Alexandra Daks
- , Alexey Petukhov
- & Nickolai Barlev
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Article
| Open AccessGIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma
- Yeqing Dong
- , Yongsheng Huang
- & Zhi Zheng
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Article
| Open AccessP2X7 receptor signaling promotes inflammation in renal parenchymal cells suffering from ischemia-reperfusion injury
- Yingying Qian
- , Cheng Qian
- & Leyi Gu
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Article
| Open AccessTranscriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells
- Zhemin Shi
- , Kun Zhang
- & Wei Hong
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Comment
| Open Access4EBP1/2 are active under standard cell culture conditions to regulate the translation of specific mRNAs
- Khawla Alasad
- , Kai Voeltzke
- & Barak Rotblat
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Article
| Open AccessInactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI
- Siyuan Sun
- , Hengqian He
- & Xiufang Xiong
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Article
| Open AccessMembrane-tethering of cytochrome c accelerates regulated cell death in yeast
- Alexandra Toth
- , Andreas Aufschnaiter
- & Martin Ott
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Article
| Open AccessHUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response
- Zongpei Guo
- , Shaozheng Wang
- & Teng Ma
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Article
| Open AccessAPN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway
- Mengying Zhai
- , Zixia Yang
- & Zheng Fu
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Article
| Open AccessHistone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells
- Lingling Fan
- , Songhui Xu
- & Jianfei Qi
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Article
| Open AccessMCL1 binding to the reverse BH3 motif of P18INK4C couples cell survival to cell proliferation
- Robert H. Whitaker
- & William J. Placzek
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Article
| Open AccessReversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)
- Xin Xu
- , Matko Kalac
- & Adrian T. Ting
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Article
| Open AccessTNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways
- Lei Gao
- , Li-you Wang
- & Dong-ying Zhang
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Article
| Open AccessPGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone
- Jinqian Liang
- , Xiang-yang Zhang
- & Ming-sheng Tan
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Article
| Open AccessPhlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice
- Changli Zhang
- , Madeline P. Smith
- & Svenja Illien-Jünger
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Article
| Open AccessThe stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway
- Stefania Scicchitano
- , Marco Giordano
- & Heather M. Bond
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Article
| Open AccessA20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
- Dario Priem
- , Michael Devos
- & Mathieu J. M. Bertrand
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Article
| Open AccessO-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
- Hyun Jik Lee
- , Young Hyun Jung
- & Ho Jae Han
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Comment
| Open AccessPTEN S-nitrosylation by NOS1 inhibits autophagy in NPC cells
- Lingqun Zhu
- , Chun Zhang
- & Qiuzhen Liu
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Article
| Open AccessTNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity
- Juliane Medler
- , Johannes Nelke
- & Harald Wajant
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Original Article
| Open AccessProteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery
- Tiago Clemente
- , Narcisio J Vieira
- & Gustavo P Amarante-Mendes
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Original Article
| Open AccessThe histone code reader Spin1 controls skeletal muscle development
- Holger Greschik
- , Delphine Duteil
- & Roland Schüle
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Original Article
| Open AccessThe fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells
- Francesca Zalfa
- , Vincenzo Panasiti
- & Claudia Bagni
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